NCT00033488

Screening Women at High Genetic Risk for Ovarian Cancer

The UK Familial Ovarian Cancer Screening Study

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 5,000 (estimated)
• Sponsor: University College London Hospitals · Academic / Other
• Sex: Female
• Age: 35 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Screening tests may help doctors detect cancer cells early and plan more effective treatment for ovarian cancer. PURPOSE: Screening trial to determine the best procedure to detect ovarian cancer in women who have a high genetic risk for developing ovarian cancer.

Detailed description

OBJECTIVES: * Determine an optimal screening procedure for ovarian cancer, in terms of the most appropriate screening test, criteria for interpretation of results, and screening intervals, in women at high genetic risk for developing ovarian cancer. * Determine the physical morbidity and the resource implications associated with ovarian cancer screening in these women. * Assess the feasibility of screening this high-risk population in terms of compliance rates. OUTLINE: Patients undergo transvaginal ultrasonography of the ovaries (scheduled for the early follicular phase, day 3-6 of the menstrual cycle) and CA 125 measurement annually. Blood samples are collected every 4 months for analysis of CA 125 levels and novel markers. Peer Reviewed and Funded or Endorsed by Cancer Research UK PROJECTED ACCRUAL: A total of 5,000 patients will be accrued for this study.

Conditions

• Ovarian Cancer

Interventions

Type	Name	Description
OTHER	cytology specimen collection procedure
PROCEDURE	annual screening
PROCEDURE	comparison of screening methods

Timeline

• Start date: 2000-09-01
• Completion: 2010-03-01
• First posted: 2003-01-27
• Last updated: 2013-12-18

Locations

2 sites across 1 country: United Kingdom