Trials / Completed
CompletedNCT00018720
Regulation of Sterol Homeostasis
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- —
- Sponsor
- US Department of Veterans Affairs · Federal
- Sex
- All
- Age
- 18 Years – 75 Years
- Healthy volunteers
- Accepted
Summary
The purpose of this study is to determine how people with high triglycerides metabolize and absorb bile acids, compounds made in the body from cholesterol. This project has two objectives: A) To define the mechanism of impaired bile acid absorption in hypertriglyceridemia (specifically we will determine if the active or passive component of absorption is abnormal) and B) to determine the contribution of an alternative pathway of bile acid synthesis which begins with 27-hydroxylation of cholesterol. Because 27-hydroxylase is present in endothelial cells as well as liver, this pathway may play a role in removal of cholesterol from incipient atherosclerotic plaque.
Conditions
Timeline
- Start date
- 1996-04-01
- Completion
- 2000-12-01
- First posted
- 2001-07-05
- Last updated
- 2009-01-21
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00018720. Inclusion in this directory is not an endorsement.