Trials / Completed
CompletedNCT00018421
Effects of Exercise on Patients With Hemiparetic Stroke
- Status
- Completed
- Phase
- N/A
- Study type
- Interventional
- Enrollment
- —
- Sponsor
- US Department of Veterans Affairs · Federal
- Sex
- All
- Age
- 40 Years – 80 Years
- Healthy volunteers
- Not accepted
Summary
This randomized trial investigates the hypothesis that regular aerobic exercise training using a task specific gait training modality will improve cardiovascular fitness, functional mobility, and reduce risk factors for recurrent cardiovascular events in chronic hemiparetic stroke patients, when compared to matched controls performing just stretching.
Detailed description
The aims are to determine whether 6 months progressive graded treadmill training: 1) improves cardiovascular fitness levels and reduces the excessive energy demands of hemiparetic gait, as defined by oxygen consumption levels based on open circuit spirometry during peak and submaximal exercise ambulation tasks; 2) increases free living physical activity measured by portable kinematic recording devices and quantitative in vivo determination of energy expenditure using stable isotopes; and, 3) improves the cardiovascular-metabolic risk factor profile including measures of key endogenous fibrinolysis regulatory enzymes \[plasma tissue plasminogen activator (t-PA) and its main circulating inhibitor (PAI-1)\], fasting lipoprotein lipid profiles, blood pressure, and oral glucose tolerance and insulin responses. Measurements of body composition at baseline and after training will further determine the effects of aerobic exercise training on muscle mass and central obesity.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| PROCEDURE | Treadmill Exercise |
Timeline
- Start date
- 1997-07-01
- Completion
- 2001-06-01
- First posted
- 2001-07-05
- Last updated
- 2009-01-21
Locations
1 site across 1 country: United States
Source: ClinicalTrials.gov record NCT00018421. Inclusion in this directory is not an endorsement.