NCT00010738

Effects of Meditation on Mechanism of Coronary Heart Disease

• Status: Completed
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 145 (planned)
• Sponsor: National Center for Complementary and Integrative Health (NCCIH) · NIH
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

To study the effects of Transcendental Meditation on Coronary Heart Disease

Detailed description

Recent advances in our understanding of the pathophysiology of acute cardiac events - specifically, identification of the roles that arterial vasomotor dysfunction and autonomic nervous system imbalances play in the pathophysiologic cascade during such acute events - provides a platform for new mechanistic investigation of the interplay of psychosomatic stress and CHD (coronary heart disease). Preliminary evidence further suggests that Complementary and Alternative Medicine (CAM) practices, such as the Transcendental Meditation (TM) technique, can not only reduce stress but also reduce acute cardiac events in patients with CHD. Based on these and related data, we propose a randomized, blinded, controlled study of the effects of one CAM practice, the TM technique, compared to a control group, on the primary outcomes of (1) arterial vasomotor dysfunction (brachial artery reactivity); (2) autonomic nervous system imbalances (heart rate variability); (3) transient myocardial ischemia (ST-segment depression); and (4) the secondary outcomes of psychological stress and quality of life (anger, hostility, anxiety, depression, perceived health, disease-specific symptoms, and life stress/social resources).

Conditions

• Coronary Heart Disease

Interventions

Type	Name	Description
PROCEDURE	Meditation

Timeline

• Start date: 1999-09-01
• Completion: 2002-08-01
• First posted: 2001-02-05
• Last updated: 2006-08-18

Locations

1 site across 1 country: United States