NCT00009711

Study of Lung Function in Children Who Have Undergone Bone Marrow Transplantation

The Impact of Pediatric Marrow Transplantation on Late Pulmonary Function

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 280 (estimated)
• Sponsor: Fred Hutchinson Cancer Center · Academic / Other
• Sex: All
• Age: 17 Years
• Healthy volunteers: Not accepted

Summary

RATIONALE: Assessing the long-term effects of bone marrow transplant on lung function in patients may improve the ability to plan treatment. PURPOSE: This clinical trial studies lung function in pediatric patients who have undergone bone marrow transplant.

Detailed description

OBJECTIVES: * Determine the delayed effects of bone marrow transplantation preparative regimens on pulmonary function in children surviving at least 5 years after transplantation for hematologic malignancy. * Determine the relationship between pulmonary function and growth rates in these patients. * Determine the effect of growth hormone treatment on pulmonary function in these patients. * Determine the relationship between pulmonary function and age at time of transplantation in these patients. * Determine the incidence and severity of restrictive pulmonary disease, and whether these factors vary with increasing time after transplantation in these patients. OUTLINE: Patients undergo respiratory history, signs and symptoms assessment, pulmonary function tests (PFT) including spirometry, lung volumes, and diffusion, oxygen saturation by pulse oximetry, and height measurement. Patients are assessed at 5-10 years, 10-15 years, and over 15 years after bone marrow transplantation. Patients with abnormal PFTs are assessed at more frequent intervals as clinically indicated. PROJECTED ACCRUAL: Approximately 280 patients will be accrued for this study.

Conditions

• Long-term Effects Secondary to Cancer Therapy in Children
• Pulmonary Complications

Interventions

Type	Name	Description
PROCEDURE	management of therapy complications

Timeline

• Start date: 1996-03-01
• Primary completion: 2004-08-01
• Completion: 2005-08-01
• First posted: 2003-01-27
• Last updated: 2013-05-01

Locations

1 site across 1 country: United States