NCT00006392

S0000 Selenium and Vitamin E in Preventing Prostate Cancer

Selenium and Vitamin E Cancer Prevention Trial (SELECT) for Prostate Cancer

• Status: Completed
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 35,533 (actual)
• Sponsor: SWOG Cancer Research Network · Network
• Sex: Male
• Age: 50 Years – 120 Years
• Healthy volunteers: Accepted

Summary

RATIONALE: Chemoprevention therapy is the use of certain drugs to try to prevent the development of cancer. It is not yet known which regimen of selenium and/or vitamin E may be more effective in preventing prostate cancer. PURPOSE: Randomized phase III trial to determine the effectiveness of selenium and vitamin E, either alone or together, in preventing prostate cancer.

Detailed description

OBJECTIVES: * Compare the effect of selenium and vitamin E administered alone vs in combination on the clinical incidence of prostate cancer. * Compare the effect of these prevention regimens on the incidence of lung cancer, colorectal cancer, and all cancers combined in participants on this study. * Compare the effect of these prevention regimens on prostate cancer-free survival, lung cancer-free survival, colorectal cancer-free survival, cancer-free survival, overall survival, and serious cardiovascular events in these participants.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
DRUG	Vitamin E	400 IU daily by mouth for 7-12 years
DRUG	Selenium	200 mcg daily for 7-12 years
OTHER	Vitamin E placebo	daily for 7-12 years
OTHER	selenium placebo	daily for 7-12 years

Timeline

• Start date: 2001-07-01
• Primary completion: 2011-05-01
• Completion: 2012-09-01
• First posted: 2003-01-27
• Last updated: 2015-11-20
• Results posted: 2012-11-06

Locations

13 sites across 1 country: United States