NCT00005105

Genetic Study of Insulin-Like Growth Factor-I Receptor Mutations in Patients With Intrauterine Growth Retardation

• Status: Unknown
• Phase: —
• Study type: Observational
• Enrollment: 75 (planned)
• Sponsor: National Center for Research Resources (NCRR) · NIH
• Sex: All
• Age: 18 Months – 18 Years
• Healthy volunteers: Not accepted

Summary

OBJECTIVES: I. Determine if mutations in the gene encoding the insulin-like growth factor-I receptor lead to relative insulin-like growth factor-I insensitivity and produce intrauterine growth retardation in children.

Detailed description

PROTOCOL OUTLINE: Patients undergo blood draw. Insulin-like growth factor-I (IGF-I) and insulin-like growth factor binding protein-3 (IGFBP-3) are measured. Patients whose IGF-I and IGFBP-3 levels are average or above are tested for the presence of mutation in the insulin-like growth factor-I receptor.

Conditions

• Intrauterine Growth Retardation

Timeline

• Start date: 1997-01-01
• First posted: 2000-04-07
• Last updated: 2005-06-24

Locations

5 sites across 1 country: United States