NCT00004458

Longitudinal and Biological Study of Childhood Disintegrative Disorder

• Status: Terminated
• Phase: —
• Study type: Observational
• Enrollment: 220 (planned)
• Sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) · NIH
• Sex: All
• Age: 2 Years – 9 Years
• Healthy volunteers: Not accepted

Summary

OBJECTIVES: I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays. II. Collect data on molecular genetics of proband and family members.

Detailed description

PROTOCOL OUTLINE: Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Conditions

• Pervasive Child Development Disorders
• Autism

Timeline

• Start date: 1997-05-01
• First posted: 1999-10-19
• Last updated: 2005-06-24

Locations

2 sites across 1 country: United States