Trials / Completed
CompletedNCT00003833
Genetic Study in Patients With Stage II or Stage III Colon Cancer
The Clinical and Pathological Significance of Allelic Imbalance of 8p in Patients With Colorectal Cancer
- Status
- Completed
- Phase
- —
- Study type
- Observational
- Enrollment
- 598 (actual)
- Sponsor
- Alliance for Clinical Trials in Oncology · Academic / Other
- Sex
- All
- Age
- 69 Years
- Healthy volunteers
- Not accepted
Summary
RATIONALE: Genetic studies may help in understanding the genetic processes that cause some types of cancer. PURPOSE: Genetic trial to study certain genes of patients who have stage II or stage III colon cancer.
Detailed description
OBJECTIVES: * Determine the adverse prognostic significance of 8p allelic imbalance (AI) in patients with colon cancer. * Determine if patient prognosis is dependent on the region of 8p AI. * Perform fine mapping studies to further localize the putative tumor suppressor gene(s) on 8p. * Perform multicolor FISH to examine the role that 8p loss and 8q gain play in the prognosis of patients whose tumors exhibit 8p AI. OUTLINE: Matched normal and tumor DNA is analyzed for 8p allelic imbalance with at least 8 markers: D8S262 and D8S1825 localized to 8p23, D8S254 and D8S261 at 8p22, D8S560 and D8S136 at 8p21, and D8S1820 and D8S283 at 8p12. Normal/tumor tissue pairs are used for fine mapping studies.
Conditions
Interventions
| Type | Name | Description |
|---|---|---|
| GENETIC | DNA stability analysis | |
| GENETIC | gene mapping |
Timeline
- Start date
- 1999-02-01
- Primary completion
- 2006-08-01
- Completion
- 2006-08-01
- First posted
- 2003-01-27
- Last updated
- 2016-07-13
Locations
59 sites across 2 countries: United States, Canada
Source: ClinicalTrials.gov record NCT00003833. Inclusion in this directory is not an endorsement.