NCT00002924

Gene Mutations in Patients With Advanced Prostate Cancer That Is Not Responsive to Hormone Therapy

Androgen Receptor Mutations in Hormone Refractory Prostate Cancer

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 184 (actual)
• Sponsor: Alliance for Clinical Trials in Oncology · Academic / Other
• Sex: Male
• Age: —
• Healthy volunteers: Not accepted

Summary

RATIONALE: Gene mutations may make prostate cancer cells unable to attach to androgens. This may permit the growth of prostate cancer. Gene testing may improve the identification of patients with advanced prostate cancer. PURPOSE: Clinical trial to study the androgen receptor gene in patients with prostate cancer that is not responsive to hormone therapy.

Detailed description

OBJECTIVES: 1. the feasibility of collecting bone marrow biopsies from prostate cancer patients in a cooperative group setting 2. the incidence of marrow invasion by prostate tumor in random bone marrow biopsy 3. the influence of previous prostate radiation on obtaining prostate tumor 4. the frequency and type of AR mutations and 5. association of AR mutations with response to antiandrogen withdrawal.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
OTHER	mutation analysis

Timeline

• Start date: 1997-01-01
• Primary completion: 2006-06-01
• Completion: 2006-06-01
• First posted: 2004-05-24
• Last updated: 2016-07-14

Locations

49 sites across 1 country: United States