| Completed | A Study in Healthy Female Participants Investigating the Effect of TMC435 on the Pharmacokinetics of the Synth Hepatitis C Virus | Phase 1 | 2011-11-01 |
| Completed | A Study in Healthy Participants Investigating the Effect of TMC435 on the Pharmacokinetics of Immunosuppressan Hepatitis C Virus | Phase 1 | 2011-10-01 |
| Completed | TMC435-TiDP16-C126 - Trial to Investigate the Effect of Severe Renal Impairment on the Pharmacokinetics and Sa Hepatitis C Virus | Phase 1 | 2011-07-01 |
| Completed | TMC435-TiDP16-C115 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC43 Hepatitis C Virus | Phase 1 | 2011-03-01 |
| Completed | TMC435-TiDP16-C116 - Relative Bioavailability and Food Effect Study Hepatitis C | Phase 1 | 2011-03-01 |
| Completed | TMC125IFD1001 - Drug-Drug Interaction of Etravirine With Telaprevir and TMC278 With Telaprevir. Hepatitis C, HIV | Phase 1 | 2011-03-01 |
| Completed | TMC278-TiDP6-C153 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC278 HIV Infections | Phase 1 | 2011-02-01 |
| Completed | TMC435-TiDP16-C117: The Effect of TMC435 on the Results of Electrocardiograms (Electric Recording of the Heart Hepatitis C | Phase 1 | 2011-01-01 |
| Completed | TMC435-TiDP16-C108 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC43 Hepatitis C Virus | Phase 1 | 2011-01-01 |
| Completed | TMC114-TiDP3-C176 - A Study in Healthy Volunteers Investigating the Bioequivalence Between Two Commercially Av Healthy | Phase 1 | 2011-01-01 |
| Completed | TMC649128HPC1001 - First In-human Trial to Examine Safety, Tolerability, and Pharmacokinetics (How the Drug is Healthy Volunteer | Phase 1 | 2011-01-01 |
| Completed | TMC435-TiDP16-C114 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC43 Hepatitis C Virus | Phase 1 | 2010-11-01 |
| Completed | TMC435-TiDP16-C123 - A Study in Healthy Volunteers Investigating the Pharmacokinetic Interaction Between TMC43 Hepatitis C Virus | Phase 1 | 2010-10-01 |
| Completed | TMC435 HPC1004 - Phase I Study Investigating the Pharmacokinetics of TMC435 in Healthy Chinese Volunteers Hepatitis C | Phase 1 | 2010-10-01 |
| Completed | TMC435-TiDP16-C125 - Study in Healthy Volunteers to Evaluate the Potential of TMC435 to Increase the Sensitivi Hepatitis C Virus | Phase 1 | 2010-07-01 |
| Completed | TMC435-TiDP16-C119 - A Study Comparing 2 New Capsule Formulations of TMC435 to an Established Capsule Formulat Hepatitis C Virus | Phase 1 | 2010-06-01 |
| Completed | TMC435-TiDP16-C112 - Interaction Trial With Antidepressants Hepatitis C Virus | Phase 1 | 2010-05-01 |
| Completed | TMC647055HPC1001 - First-in-human Trial to Examine Safety, Tolerability and Pharmacokinetics (How the Drug is Hepatitis C | Phase 1 | 2010-04-01 |
| Completed | TMC125HIV1083 - Swallowability of Uncoated 200 mg Etravirine Tablets in HIV-1 Infected Patients HIV-Infections | Phase 1 | 2010-03-01 |
| Completed | TMC114-TiDP3-C182 - A Study to Compare the Oral Bioavailability of a 800 mg Prototype Tablet Formulation of Da HIV Infections | Phase 1 | 2010-03-01 |
| Completed | TMC278-TiDP15-C158 - A Study to Examine the Safety, Tolerability and Pharmacokinetics of a Single Dose or Thre HIV Infections | Phase 1 | 2010-01-01 |
| Completed | TMC435-TiDP16-C113: A Study to Investigate the Effect of Hepatic Impairment on the Pharmacokinetics of TMC435 Hepatitis C Virus | Phase 1 | 2010-01-01 |
| Completed | TMC435-TiDP16-C121: A Study Comparing 2 Tablet Formulations of TMC435 to an Established Capsule Formulation an Hepatitis C Virus | Phase 1 | 2010-01-01 |
| Completed | TMC278-TiDP6-C154: Evaluation of the Possible Influence of Omeprazole Intake - and the pH Increase in the Stom HIV Infections | Phase 1 | 2010-01-01 |
| Completed | A Safety and Effectiveness Study of TMC435 in Chronic, Genotype 1, Hepatitis C Patients Who Failed to Previous Hepatitis C | Phase 2 | 2009-10-01 |
| Completed | A Safety Study to Evaluate the Antiviral Activity of Darunavir in Combination With Ritonavir in HIV 1 Infected Human Immunodeficiency Virus 1 | Phase 2 | 2009-09-01 |
| Completed | A Study to Investigate the Potential Pharmacokinetic Interaction Between TMC435 and Methadone Hepatitis C | Phase 1 | 2009-09-01 |
| Completed | A Study to Evaluate Antiviral Activity of Darunavir + Ritonavir in HIV-1 Infected Adolescents HIV-1 Infection | Phase 2 | 2009-07-01 |
| Completed | A Study of TMC435 in Combination With Pegylated Interferon Alp\Fa-2a and Ribavirin in Patients Infected With G Hepatitis C | Phase 2 | 2009-06-01 |
| Completed | A Study to Determine the Antiviral Activity of TMC310911 When Administered With Ritonavir in Treatment-Naive H Human Immunodeficiency Virus Type 1 | Phase 2 | 2009-06-01 |
| Withdrawn | PEPI-TiDP23-C104 is a First in Human Study With a Single Dose Escalation Part and a Multiple Dosing Part for C HIV Infections | Phase 1 | 2009-05-01 |
| Completed | TMC435-TiDP16-C107: This Study Measures the (Possible) Influence of TMC435 on the Activity of a Selected Set o Hepatitis C, Viruses | Phase 1 | 2009-03-01 |
| Completed | TMC125-TiDP2-C188: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Effect of Multiple-dose TMC1 HIV, Pharmacokinetics | Phase 1 | 2009-03-01 |
| Completed | A Study to Assess the Anti-viral Activity, Safety, Tolerability and Pharmacokinetics of TMC435350 in Participa Hepatitis C | Phase 2 | 2009-03-01 |
| Completed | PEPI-TiDP23-C103: First-in-Human Study to Examine the Safety, Tolerability, and Plasma Pharmacokinetics of Inc HIV-1 | Phase 1 | 2009-02-01 |
| Completed | TMC278-TiDP38-C145: A Bioavailability Study in Healthy Adult Volunteers to Evaluate 3 Pediatric Formulations o Pharmacokinetics, Bioavailability, HIV-1 | Phase 1 | 2009-01-01 |
| Completed | TMC125-TiDP35-C213: Safety and Antiviral Activity of Etravirine (TMC125) in Treatment-Experienced, HIV Infecte HIV-1 | Phase 2 | 2008-11-01 |
| Completed | Innovation-TiFP4-C101: A Study to Evaluate the Pharmacokinetics of TMC114 and TMC41629 After a Single Oral Dos HIV-I | Phase 1 | 2008-11-01 |
| Completed | TMC278-TiDP6-C121: Drug-drug Interaction Trial to Investigate the Potential Interaction Between TMC278 25 mg D HIV | Phase 1 | 2008-10-01 |
| Completed | TMC125-TiDP2-C187: A Phase I, Open-label Trial to Investigate the Pharmacokinetic Interaction Between TMC125 a HIV, AIDS, Fungal Infection | Phase 1 | 2008-09-01 |
| Completed | TMC125-TiDP2-C197: A Phase I Trial to Investigate the Pharmacokinetic Interaction Between Lopinavir/Ritonavir HIV | Phase 1 | 2008-09-01 |
| Completed | TMC435350-TiDP16-C109: A Safety Study for TMC435350 in an Oral Solution Containing Either 100, 200 or 400 mg E HCV | Phase 1 | 2008-08-01 |
| Completed | TMC114-TiDP3-C181: Study to Assess the Pharmacokinetics of Darunavir (DRV) With Different Doses of Ritonavir i HIV, AIDS | Phase 1 | 2008-08-01 |
| Completed | TMC278-TiDP6-C152: A Study to Assess the Effects of TMC278 and Efavirenz (EFV) on the QT/QTc Interval (Heart C Human Volunteers | Phase 1 | 2008-08-01 |
| Terminated | TMC278-TiDP15-C150: Trial to Examine Safety, Tolerability and Plasma Pharmacokinetics of Multiple Doses of TMC HIV-1 | Phase 1 | 2008-07-01 |
| Completed | TMC278-TiDP6-C136: Effect of TMC278 on Ethinylestradiol and Norethindrone in Healthy Women. HIV, AIDS, Oral Contraceptive | Phase 1 | 2008-07-01 |
| Completed | TMC435350-TiDP16-C106: A Phase I Trial to Compare the Bioavailability and Plasma Pharmacokinetics After a Sing Hepatitis C, HCV | Phase 1 | 2008-07-01 |
| Completed | TMC278-TiDP6-C130: Pharmacokinetics, Safety and Tolerability of TMC278 in Subjects With Mildly or Moderately I HIV, AIDS, Hepatic Impairment | Phase 1 | 2008-06-01 |
| Completed | TMC278-TiDP6-C215: A Clinical Trial in Treatment Naive HIV-subjects Patients Comparing TMC278 to Efavirenz in HIV Infections, HIV-1 | Phase 3 | 2008-06-01 |
| Completed | TMC435350-TiDP16-C105: Phase I, 3-way Crossover, Drug-drug Interaction Between TMC435350 and Rifampin After Mu Hepatitis C, HCV, Tuberculosis | Phase 1 | 2008-06-01 |
| Completed | TMC278-TiDP6-C209: A Clinical Trial in Treatment Naive HIV-1 Patients Comparing TMC278 to Efavirenz in Combina HIV Infections, HIV-1, Human Immunodeficiency Virus Type 1 | Phase 3 | 2008-05-01 |
| Completed | TMC114-TiDP29-C169: Bioavailability and Pharmacokinetics Trial Comparing Darunavir Pediatric Suspension Formul Pharmacokinetics | Phase 1 | 2008-04-01 |
| Completed | A Study of TMC435350 Administered With or Without Standard of Care Therapy in Participants With Genotype 1 Hep Hepatitis C, Chronic | Phase 2 | 2008-01-01 |
| Completed | A Study to Compare Effectiveness and Safety of Darunavir/Ritonavir (DRV/Rtv) 800mg/100mg Once Daily Versus DRV Human Immunodeficiency Virus - Type 1 | Phase 3 | 2007-10-01 |
| Completed | A Study of Drug-drug Interaction Between Ritonavir and TMC435350 in Healthy Volunteers Healthy | Phase 1 | 2007-10-01 |
| Completed | TMC435350-TiDP16-C101 - A Study to Examine the Safety, Tolerability and Pharmacokinetics of Increasing Oral Do Hepatitis C | Phase 1 | 2007-01-01 |
| Terminated | TMC114-C227: A Study to Evaluate the Effectiveness and Safety of TMC114 (Darunavir) With a Low Dose of Ritonav HIV Infections | Phase 2 | 2006-09-01 |
| Completed | An Open-label Trial With TMC125 in Patients Who Have Virologically Failed in a DUET Trial (TMC125-C206 or TMC1 HIV-1 | Phase 3 | 2006-06-01 |
| Completed | A Phase 2 Study to Evaluate Pharmacokinetics, Safety and Efficacy of TMC114/Ritonavir (Rtv) in Human Immunodef HIV-1, HIV Infections | Phase 2 | 2006-06-01 |
| Completed | The TMC125-C214 Study Provides Early Access to TMC125 for HIV-1 Infected Patients Who Have Failed Multiple Ant HIV-1 | Phase 3 | 2006-01-01 |
| Completed | TMC125-C216: A Phase III Study to Investigate the Efficacy, Tolerability and Safety of TMC125 as Part of an An HIV | Phase 3 | 2005-12-01 |
| Completed | TMC125-C206: A Phase III Study to Investigate the Efficacy, Tolerability and Safety of TMC125 as Part of an An HIV | Phase 3 | 2005-11-01 |
| Completed | TMC114-C211: Trial of an Investigational Protease Inhibitor TMC114 With Ritonavir ("TMC114/r") in HIV-1 Infect HIV | Phase 3 | 2005-09-01 |
| Completed | A Study of TMC278 in Human Immunodeficiency Virus Type 1 Infected Patients, Who Are Not Treated With Antiretro Human Immunodeficiency Virus Type 1 | Phase 2 | 2005-06-01 |
| Completed | A Study With TMC125 in Human Immunodeficiency Virus (HIV) Type 1 Infected Patients, Who Were Treated With TMC1 Human Immunodeficiency Virus Type 1 | Phase 2 | 2005-06-01 |
| Completed | TMC114-C209: A Study of Safety of TMC114 With Low Dose Ritonavir (RTV) and Other Antiretrovirals in Experience HIV Infections | Phase 3 | 2005-06-01 |
| Completed | TMC114-C214: Trial of TMC114 Administered With Low Dose Ritonavir (RTV) in HIV-1 Infected Treatment Experience HIV Infection | Phase 3 | 2005-04-01 |
| Completed | TMC125-C227: A Phase II Randomized, Active-Controlled, Open Label Trial to Investigate the Efficacy and Tolera HIV Infection | Phase 2 | 2005-03-01 |
| Completed | A Study to Assess the Long-term Safety and Tolerability of TMC114/Rtv in HIV-1 Infected Participants After Rol HIV | Phase 2 | 2005-01-01 |
| Completed | TMC125-C211: Trial of TMC125 in HIV-1 Infected Subjects Who Were in a Sponsor Selected TMC125 Trial HIV Infection | Phase 2 | 2004-09-01 |
| Completed | TMC125-C223: TMC125 in HIV-1 Infected Subjects HIV Infection | Phase 2 | 2004-03-01 |
| Completed | An Open Label Trial of TMC114/RTV in HIV-1 Infected, Treatment-experienced Subjects. HIV Infection | Phase 2 | 2003-11-01 |
| Completed | TMC114-C202: A Study of Safety, Efficacy, and Tolerability of TMC114 and Low Dose Ritonavir in HIV-1 Infected HIV Infections | Phase 2 | 2003-10-01 |
| Completed | TMC114-C213: A Phase II Randomized, Controlled, Partially Blinded Trial to Investigate Dose-response of TMC114 HIV | Phase 2 | 2003-10-01 |
| Completed | TMC125-C203: Phase II Randomized (Patients Are Assigned Different Treatments Based on Chance), Placebo Control Anti-Retroviral Agents, HIV-1 | Phase 2 | 2002-06-01 |
| Completed | TMC114-C201: A Study to Determine the Antiviral Activity of TMC114 in Patients With Multiple Protease Inhibito HIV Infections | Phase 2 | 2001-08-01 |
| Approved For Marketing | TMC114-C226: An Early Access Program to Evaluate the Long-term Safety and Tolerability of TMC114 Combined With HIV Infections | — | — |