| Recruiting | Study to Collect Real-world Performance and Safety Data on Penumbra System® in Population With Acute Ischemic Acute Ischemic Stroke (AIS) | — | 2025-11-01 |
| Recruiting | A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo™ Aspiration Sy Lower Extremity Acute Limb Ischemia, LE ALI | — | 2025-05-18 |
| Completed | Post Market Surveillance to Evaluate the Efficacy and Safety of the INDIGO Aspiration System in Japan Acute Limb Ischemia, Arterial Occlusion Mesenteric Artery Superior, Acute DVT of Lower Extremity | — | 2023-12-07 |
| Completed | Comparison of Two Pulmonary Embolism Treatments Pulmonary Embolism Acute | N/A | 2023-11-27 |
| Completed | THUNDER: Acute Ischemic Stroke Study with the Penumbra System® Including Thunderbolt™ Aspiration Tubing Acute Ischemic Stroke, Large Vessel Occlusion | N/A | 2022-08-11 |
| Active Not Recruiting | BOLT: Study of the Indigo® Aspiration System When Used in Patients With Deep Vein Thrombosis Deep Vein Thrombosis, DVT | N/A | 2021-09-30 |
| Recruiting | Study of the Long-Term Safety and Outcomes of Treating Pulmonary Embolism With the Indigo Aspiration System Pulmonary Embolism | — | 2021-06-25 |
| Completed | Investigation of Clot in Ischemic Stroke and Hematoma Evacuation Ischemic Stroke, Intracranial Hematoma | — | 2021-02-16 |
| Terminated | LOTUS: Global Acute Stroke Study Utilizing Penumbra System Stroke, Ischemic | — | 2020-01-12 |
| Completed | A Study of Patients With Lower Extremity Acute Limb Ischemia to Remove Thrombus With the Indigo Aspiration Sys Lower Extremity Acute Limb Ischemia, LE ALI | — | 2019-12-17 |
| Completed | Assessing the WAVE Extra Soft Coil in Intracranial Aneurysms and Comparing Imaging Modalities Aneurysm, Brain | — | 2019-11-05 |
| Terminated | PRONTO: Artemis in the Removal of Intraventricular Hemorrhage in the Hyper-Acute Phase Intracerebral Hemorrhage, Brain Hemorrhage, Intraventricular Hemorrhage | — | 2019-09-26 |
| Completed | Study of the CAT RX Aspiration Catheter When Used in Patients With Large Occlusive Thrombus in Coronary Arteri Coronary Vessel Occlusion | — | 2019-08-22 |
| Completed | COMPLETE: International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D Re Stroke, Ischemic | — | 2018-07-02 |
| Completed | MIND: Artemis in the Removal of Intracerebral Hemorrhage Cerebral Hemorrhage, Brain Hemorrhage, Cerebral Parenchymal Hemorrhage | N/A | 2018-02-06 |
| Completed | Evaluating the Safety and Efficacy of the Indigo® Aspiration System in Acute Pulmonary Embolism Pulmonary Embolism | N/A | 2017-11-22 |
| Withdrawn | Visceral Artery Aneurysm Embolization by the Penumbra Ruby™ Coil System Visceral Artery Aneurysms, Arteriovenous Malformations | Phase 4 | 2017-06-01 |
| Completed | Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil Intracranial Aneurysm | N/A | 2016-06-03 |
| Completed | European Registry on the ACE Reperfusion Catheters and the Penumbra System in the Treatment of Acute Ischemic Ischemic Stroke | — | 2016-02-01 |
| Terminated | CARE: A Prospective Multicenter Case Study to Assess Radiation Exposure in Patients Treated With the Penumbra Intracranial Aneurysms | — | 2015-05-01 |
| Completed | Case Review of the Penumbra and Indigo Systems for Mechanical Thrombectomy in the Periphery Peripheral Arterial Occlusion or Emboli | N/A | 2014-03-01 |
| Completed | A Volumetric Coiling in Aneurysm Registry of the Penumbra Coil 400TM System Intracranial Aneurysms | — | 2013-01-01 |
| Completed | A Clinical Trial to Assess the Acute Safety and Functional Outcome and Recovery After STROKE: The FIRST Trial Stroke | — | 2012-12-01 |
| Withdrawn | Safety and Performance of the Penumbra Liberty Stent in the Treatment of Wide-Neck, Saccular, Intracranial Ane Wide Neck Intracranial Aneurysms | Phase 2 | 2012-12-01 |
| Completed | The Penumbra Liberty Trial: Safety and Effectiveness in the Treatment of Wide-Neck Intracranial Aneurysms Wide-neck, Saccular Intracranial Aneurysms | N/A | 2012-09-01 |
| Completed | Assess the Penumbra System in the Treatment of Acute Stroke Ischemic Stroke | Phase 4 | 2012-05-01 |
| Completed | A Randomized, Concurrent Controlled Trial to Assess the Safety and Effectiveness of the Separator 3D as a Comp Acute Ischemic Stroke From Large Vessel Occlusion | N/A | 2012-04-01 |
| Completed | Study of the Penumbra Coil 400 System to Treat Aneurysm Intracranial Aneurysms, Peripheral Aneurysms | N/A | 2011-11-01 |
| Completed | A Study of Survival and Outcome After Stroke Ischemic Stroke | — | 2010-09-01 |
| Completed | Imaging Guided Patient Selection for Interventional Revascularization Therapy Acute Ischemic Stroke | N/A | 2009-09-01 |
| Completed | Penumbra Imaging Collaborative Study (PICS) Stroke | — | 2008-10-01 |
| Completed | Study to Assess the Safety and Effectiveness of the Penumbra System Stroke | Phase 2 | 2006-06-01 |