| Recruiting | Conquer-AF Protocol for Redo Ablation Procedures in Recurrent Paroxysmal and Persistent Atrial Fibrillation Us Atrial Fibrillation (AF), Persistent Atrial Fibrillation, Paroxysmal Atrial Fibrillation (PAF) | N/A | 2026-04-08 |
| Recruiting | Horizon 360 Protocol for the Treatment of Paroxysmal Atrial Fibrillation With the Sphere-360™ Catheter and Aff Paroxysmal AF | N/A | 2026-01-15 |
| Recruiting | SPHERE Per-AF Post-Approval Study Persistent Atrial Fibrillation | — | 2025-09-25 |
| Recruiting | Safety and Performance Assessment of the Sphere-9™ Catheter and Affera™ Ablation System for the Treatment of V Ventricular Tachycardia (VT) | N/A | 2025-03-18 |
| Recruiting | PULSED AF Post-Approval Study Atrial Fibrillation | — | 2024-11-04 |
| Recruiting | PulseSelect™ PFA Global Registry Atrial Fibrillation | — | 2024-07-23 |
| Recruiting | Affera Global Registry Atrial Fibrillation | — | 2023-12-22 |
| Recruiting | STOP AF First Post-Approval Study Paroxysmal Atrial Fibrillation | — | 2022-04-28 |
| Terminated | DIAMOND AF Post-Approval Study Paroxysmal Atrial Fibrillation | — | 2022-02-28 |
| Completed | Treatment of Persistent Atrial Fibrillation With Sphere-9 Catheter and Affera Mapping and Ablation System Atrial Fibrillation | N/A | 2021-12-14 |
| Recruiting | Safety and Performance of the Affera SpherePVI™ Multi-Ablation System to Treat Paroxysmal Atrial Fibrillation Atrial Fibrillation | N/A | 2021-10-19 |
| Active Not Recruiting | STOP Persistent AF PAS Persistent Atrial Fibrillation | — | 2021-08-19 |
| Recruiting | Safety and Performance of the SpherePVI™ Catheter to Treat Paroxysmal Atrial Fibrillation Atrial Fibrillation | N/A | 2021-07-22 |
| Recruiting | DiamondTemp Global Registry Arrhythmia | — | 2021-04-22 |
| Completed | Pulsed Field Ablation to Irreversibly Electroporate Tissue and Treat AF Atrial Fibrillation | N/A | 2019-12-10 |
| Completed | ArcticLine Feasibility Study Atrial Fibrillation, Atrial Flutter | N/A | 2018-10-18 |
| Completed | DiamondTemp™ System for the Treatment of Persistent Atrial Fibrillation Persistent Atrial Fibrillation, Atrial Fibrillation | N/A | 2018-09-19 |
| Completed | Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System for Treatment of Atrial and Ventri Atrial Fibrillation, Atrial Flutter, Ventricular Tachycardia | N/A | 2018-06-01 |
| Completed | An Initial Assessment of the Sphere-9™ Catheter and Affera Mapping and Ablation System Atrial Fibrillation, Atrial Flutter | — | 2018-05-01 |
| Completed | FIRE AND ICE Re-Ablations (Retrospective Data Collection) Atrial Fibrillation, Paroxysmal Atrial Fibrillation | — | 2018-01-18 |
| Completed | DiamondTemp™ Ablation System for the Treatment of Paroxysmal Atrial Fibrillation Paroxysmal Atrial Fibrillation, Atrial Fibrillation | N/A | 2017-11-06 |
| Completed | STOP AF First: Cryoballoon Catheter Ablation in an Antiarrhythmic Drug Naive Paroxysmal Atrial Fibrillation Atrial Fibrillation, Atrial Fibrillation New Onset | N/A | 2017-06-23 |
| Completed | STOP Persistent AF Atrial Fibrillation | N/A | 2017-03-02 |
| Completed | Spanish Registry of Cryoballoon Ablation Atrial Fibrillation | — | 2016-07-01 |
| Completed | Cryo Global Registry Atrial Fibrillation | — | 2016-05-02 |
| Completed | ACT DiamondTemp TempeRAture-Controlled and Contact Sensing RF Ablation Clinical Trial for Atrial Fibrillation Paroxysmal Atrial Fibrillation | N/A | 2016-01-01 |
| Completed | Postmarket Evaluation of the Phased Radio Frequency Ablation System (GOLD AF Registry) Atrial Fibrillation | — | 2015-03-01 |
| Completed | Cryoballoon Ablation for Early Persistent Atrial Fibrillation (Cryo4 Persistent AF) Atrial Fibrillation | N/A | 2014-12-08 |
| Completed | Catheter Cryoablation Versus Antiarrhythmic Drug as First-Line Therapy of Paroxysmal Atrial Fibrillation Symptomatic Paroxysmal Atrial Fibrillation Without Clinically Significant Heart Diseases | Phase 4 | 2014-06-01 |
| Terminated | Evaluation of the Phased Radio Frequency Ablation System Persistent Atrial Fibrillation | N/A | 2013-11-01 |
| Completed | Sustained Treatment of Paroxysmal Atrial Fibrillation Post-Approval Study (STOP AF PAS) Paroxysmal Atrial Fibrillation (PAF) | N/A | 2012-06-26 |
| Completed | Intracardiac CrYoablation for AtrioVentricular Nodal Reentrant Tachycardia AtrioVentricular Nodal Reentrant Tachycardia, Supraventricular Tachycardia, Heart Disease | Phase 3 | 2012-05-01 |
| Completed | FIRE AND ICE: Comparative Study of Two Ablation Procedures in Patients With Atrial Fibrillation Symptomatic Paroxysmal Atrial Fibrillation (PAF) | N/A | 2011-12-01 |
| Completed | Study for Atrial Fibrillation Reduction (SAFARI) Atrial Fibrillation, Bradycardia | N/A | 2002-09-01 |