| Not Yet Recruiting | MDMA in Subjects With Moderate Hepatic Impairment and Subjects With Normal Hepatic Function Pharmacokinetics, Hepatic Impairment | Phase 1 | 2026-03-29 |
| Withdrawn | A Multi-Site Study of MDMA-Assisted Psychotherapy for Eating Disorders Anorexia Nervosa Restricting Type, Binge-Eating Disorder | Phase 2 | 2026-02-01 |
| Withdrawn | Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers (MT-2) Psychological Effects of Study Drug | Phase 1 | 2024-12-01 |
| Withdrawn | Study of Feasibility and Safety of MDMA-Assisted Group Therapy for the Treatment of PTSD in Veterans PTSD | Phase 2 | 2023-09-01 |
| Withdrawn | Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD Posttraumatic Stress Disorder | Phase 2 | 2022-08-01 |
| Completed | Food Effects on Bioavailability of MDMA in Healthy Volunteers Pharmacokinetics | Phase 1 | 2022-07-28 |
| Terminated | Study Comparing Two Versus Three Active MDMA-assisted Sessions in U.S. Military Veterans With Chronic PTSD PTSD | Phase 2 | 2021-11-08 |
| Completed | A Multi-Site Open-Label Extension Study of MDMA-Assisted Psychotherapy for PTSD PTSD | Phase 3 | 2021-03-08 |
| Completed | Long-Term Safety and Effectiveness of MDMA-Assisted Therapy for PTSD PTSD | — | 2021-03-01 |
| Completed | A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP2) Posttraumatic Stress Disorder | Phase 3 | 2020-09-02 |
| Completed | A Multi-Site Phase 3 Study of MDMA-Assisted Psychotherapy for PTSD (MAPP1) Posttraumatic Stress Disorder | Phase 3 | 2018-11-21 |
| Completed | Study of Safety and Effects of MDMA-assisted Psychotherapy for Treatment of PTSD (Canada) Posttraumatic Stress Disorder | Phase 2 | 2018-03-13 |
| Completed | Open Label Multi-Site Study of Safety and Effects of MDMA-assisted Therapy for Treatment of PTSD PTSD | Phase 2 | 2017-11-16 |
| Completed | Evaluation of MDMA on Startle Response Startle Response | Phase 1 | 2017-03-14 |
| Completed | MDMA-Assisted Cognitive-Behavioral Conjoint Therapy (CBCT) in Dyads in Which 1 Member Has Chronic PTSD Posttraumatic Stress Disorder | Phase 1 / Phase 2 | 2016-07-03 |
| Completed | Correlates of Anxiety Associated With a Life-threatening Illness Anxiety | — | 2015-11-07 |
| Completed | MDMA-Assisted Psychotherapy for Anxiety Associated With a Life-Threatening Illness Anxiety | Phase 2 | 2015-05-14 |
| Terminated | Randomized, Double-blind, Controlled of MDMA-assisted Psychotherapy in 12 Subjects With PTSD Posttraumatic Stress Disorder | Phase 2 | 2014-10-14 |
| Completed | Phase 2 Pilot Safety Study of MDMA-assisted Therapy for Social Anxiety in Autistic Adults Social Anxiety in Autistic Adults | Phase 2 | 2014-04-11 |
| Completed | Exploring Mechanisms of Action in MDMA-assisted Psychotherapy for PTSD Posttraumatic Stress Disorder | — | 2014-01-01 |
| Completed | Dose-Response Study of MDMA-assisted Psychotherapy in People With PTSD Posttraumatic Stress Disorder | Phase 2 | 2013-05-13 |
| Completed | Randomized, Double-blind, Placebo-Controlled Pilot Study of MDMA-assisted Therapy for PTSD Posttraumatic Stress Disorder (PTSD) | Phase 2 | 2013-01-17 |
| Completed | Psychological Effects of Methylenedioxymethamphetamine (MDMA) When Administered to Healthy Volunteers Psychological Effects of Study Drug | Phase 1 | 2011-04-09 |
| Completed | Additional MDMA-assisted Therapy for People Who Relapsed After MDMA-assisted Therapy Trial Posttraumatic Stress Disorder | Phase 2 | 2010-12-15 |
| Completed | Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder Posttraumatic Stress Disorder | Phase 2 | 2010-11-10 |
| Terminated | Randomized Placebo-controlled Study of MDMA-assisted Therapy in People With PTSD - Israel Posttraumatic Stress Disorder | Phase 2 | 2007-05-27 |
| Completed | Study of 3,4-Methylenedioxymethamphetamine-assisted Psychotherapy in People With Posttraumatic Stress Disorder Posttraumatic Stress Disorder | Phase 2 | 2006-09-13 |
| Completed | MDMA-Assisted Psychotherapy in People With Posttraumatic Stress Disorder Posttraumatic Stress Disorder | Phase 2 | 2004-03-12 |
| No Longer Available | A Multi-site Expanded Access Program for MDMA-assisted Psychotherapy for Patients With Treatment-resistant PTS Post Traumatic Stress Disorder | — | — |