| Recruiting | A Study to Evaluate the Long-term Safety and Tolerability of KarXT and KarX-EC for the Treatment of Schizophre Schizophrenia, Autism-Related Irritability | Phase 3 | 2026-03-31 |
| Recruiting | KarXT Concentrations in the Breast Milk and Plasma of Lactating Females Healthy Volunteers | Phase 4 | 2026-01-09 |
| Recruiting | A Study to Evaluate the Effects of CYP2D6 Phenotypes on the Pharmacokinetics of Xanomeline Following KarXT Adm Healthy Volunteers | Phase 1 | 2025-10-13 |
| Recruiting | A Study to Evaluate the Effects of KarXT on the Drug Levels of Midazolam, Fexofenadine, and Digoxin Healthy Volunteers | Phase 1 | 2025-09-29 |
| Completed | A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT an Healthy Volunteers | Phase 1 | 2024-12-26 |
| Completed | Study to Assess Safety and Effectiveness of Slowly Increasing Dose and Food Effect of KarXT in Participants Wi Schizophrenia | Phase 3 | 2024-10-28 |
| Completed | A Study to Assess the Safety, Tolerability and Pharmacokinetics (PK) of Xanomeline With Trospium Chloride Vers Healthy Volunteers | Phase 1 | 2024-10-01 |
| Recruiting | A Study to Evaluate KarXT as a Treatment for Psychosis Associated With Alzheimer's Disease (ADEPT-4) Alzheimer Disease | Phase 3 | 2024-09-26 |
| Active Not Recruiting | A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Dise Psychosis Associated With Alzheimer's Disease | Phase 3 | 2023-08-28 |
| Recruiting | Open-Label Extension Study to Assess the Long-Term Safety and Tolerability of KarXT in Subjects With Psychosis Psychosis Associated With Alzheimer's Disease | Phase 3 | 2023-07-11 |
| Completed | A Study to Assess the Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Chinese Adult Subjects Wi Schizophrenia | Phase 3 | 2023-05-29 |
| Terminated | An Open-label Study to Assess the Long-term Safety, Tolerability, Effectiveness, and Durability of Effect of K Schizophrenia | Phase 3 | 2022-11-08 |
| Recruiting | A Study to Assess Efficacy and Safety of KarXT for the Treatment of Psychosis Associated With Alzheimer's Dise Psychosis Associated With Alzheimer's Disease | Phase 3 | 2022-08-23 |
| Recruiting | An Extension Study to Assess Long-Term Safety and Tolerability of Adjunctive KarXT in Subjects With Inadequate Schizophrenia | Phase 3 | 2022-03-07 |
| Completed | A Study to Assess Efficacy and Safety of Adjunctive KarXT in Subjects With Inadequately Controlled Symptoms of Schizophrenia | Phase 3 | 2021-11-12 |
| Completed | An Open-label Study to Assess the Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schizophrenia | Phase 3 | 2021-06-02 |
| Completed | A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophr Schizophrenia, Schizophrenia; Psychosis | Phase 3 | 2021-04-06 |
| Completed | An Extension Study to Assess Long-term Safety, Tolerability, and Efficacy of KarXT in Adult Patients With Schi Schizophrenia | Phase 3 | 2021-02-01 |
| Completed | A Study to Assess Efficacy and Safety of KarXT in Acutely Psychotic Hospitalized Adult Patients With Schizophr Schizophrenia, Schizophrenia; Psychosis | Phase 3 | 2020-12-16 |
| Completed | A Study to Assess Safety and Efficacy of KarXT in Adult Patients With Schizophrenia Schizophrenia | Phase 2 | 2018-09-18 |
| Completed | Pilot Study Comparing Effects of Xanomeline Alone to Xanomeline Plus Trospium Schizophrenia | Phase 1 | 2016-09-07 |