| Completed | Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008 HIV Infections | Phase 1 | 2022-08-01 |
| Completed | PK, Safety Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel Pharmacokinetics, Safety Issues, Bleeding | Phase 1 | 2022-06-20 |
| Completed | PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel Healthy, Contraception, Contraceptive Usage | Phase 1 | 2018-07-17 |
| Completed | A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings HIV-1-infection | Phase 1 | 2017-12-04 |
| Withdrawn | Reversing the Epidemic in Africa With Choices in HIV Prevention (REACH) HIV-1-infection | Phase 2 | 2017-11-01 |
| Completed | PK and Safety Study of Vaginal Rings Containing Dapivirine and Levonorgestrel HIV Prevention | Phase 1 | 2017-05-03 |
| Completed | Trial to Assess the Continued Safety of and Adherence to a Vaginal Ring Containing Dapivirine in Women Human Immunodeficiency Virus | Phase 3 | 2016-07-18 |
| Completed | To Assess Continued Safety of and Adherence to the Dapivirine (25 mg) Vaginal Ring-004 in Healthy, HIV-negativ HIV Prevention | Phase 3 | 2016-07-12 |
| Completed | Evaluate the Safety & Assess Local and Systemic PK of DS003 Vaginal Tablets Administered to Healthy HIV-negati HIV | Phase 1 | 2015-11-18 |
| Withdrawn | Dapivirine Gel Rectal Safety and PK Study HIV 1 Infection | Phase 1 | 2015-09-29 |
| Completed | To Assess the Drug-drug Interaction Potential Between Dapivirine Vaginal Ring-004, Containing 25 mg of Dapivir HIV- Prevention | Phase 1 | 2015-09-01 |
| Completed | Pharmacokinetic Study of the Dapivirine Vaginal Ring in Lactating Women Human Immunodeficiency Virus | Phase 1 | 2015-02-01 |
| Completed | A Trial In Healthy HIV-Negative Women To Assess The Effect Of Menses And Tampon Use On The Pharmacokinetics Of HIV | Phase 1 | 2015-01-12 |
| Completed | Safety and Pharmacokinetic Study of Oral Maraviroc and Maraviroc 1% Gel in HIV-1 Seronegative Adults HIV/AIDS | Phase 1 | 2015-01-01 |
| Completed | Study of Dapivirine Vaginal Ring (VR) in Adolescents Human Immunodeficiency Virus | Phase 2 | 2014-06-27 |
| Completed | Safety and Pharmacokinetics of Dapivirine Vaginal Ring in Post-menopausal Women Human Immunodeficiency Virus | Phase 2 | 2013-12-01 |
| Completed | Expanded Use PK of Dapivirine Vaginal Ring Pharmacokinetics | Phase 1 | 2013-11-01 |
| Completed | PK/PD of Single Dose Dapivirine Vaginal Film Pharmaokinetics | Phase 1 | 2013-09-01 |
| Completed | A Trial to Assess the Functionality of Female Condom With a Silicone Elastomer Vaginal Ring Human Immunodeficiency Virus | Phase 1 | 2013-08-01 |
| Completed | Functionality of Male Condoms With a Silicone Elastomer Vaginal RIng Human Immunodeficiency Virus | Phase 1 | 2013-02-01 |
| Completed | DDI Potential: Dapivirine Vaginal Ring and Miconazole Nitrate HIV | Phase 1 | 2012-12-01 |
| Completed | Observational Study of HIV Infection in Participants of Seroconvert During Dapivirine Vaginal Ring Trials HIV Infections | — | 2012-10-04 |
| Completed | Assessing the Safety of Dapivirine Gel and Film Formulations HIV Infections | Phase 1 | 2012-08-01 |
| Completed | Phase 3 Safety and Effectiveness Trial of Dapivirine Vaginal Ring for Prevention of HIV-1 in Women HIV Infections | Phase 3 | 2012-07-24 |
| Completed | Safety and Efficacy Trial of a Dapivirine Vaginal Matrix Ring in Healthy HIV-Negative Women HIV Infections | N/A | 2012-03-27 |
| Completed | Safety and Pharmacokinetics of Dapivirine/Maraviroc Vaginal Ring HIV Infections | Phase 1 | 2011-11-01 |
| Withdrawn | A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa HIV Infections | Phase 3 | 2011-07-01 |
| Withdrawn | A Safety and Efficacy Trial of Dapivirine Vaginal Ring in Africa HIV Infections | Phase 3 | 2011-07-01 |
| Completed | Male Tolerance Study of Dapivirine Gel Following Multiple Topical Penile Exposures Topical Penile Exposures | Phase 1 | 2011-03-01 |
| Withdrawn | A Safety and Pharmacokinetic Study for Dapivirine and Maraviroc Gel in Belgium HIV Infections | Phase 1 | 2011-01-01 |
| Completed | A Safety Study to Assess the Delivery of Dapivirine From a Matrix Vaginal Ring HIV Infections | Phase 1 | 2010-04-01 |
| Completed | A Safety Study of Dapivirine Vaginal Ring in Africa HIV Infections | Phase 1 / Phase 2 | 2010-04-01 |
| Completed | An Expanded Safety Study of Dapivirine Gel 4759 in Africa HIV Infections, Acquired Immunodeficiency Syndrome | Phase 1 / Phase 2 | 2009-11-01 |
| Completed | Safety and Pharmacokinetic Trial in Healthy HIV-Negative Women to Assess the Delivery of Dapivirine From a Vag HIV Infections | Phase 1 | 2009-08-01 |
| Completed | A Safety Study of Two Dapivirine (TMC120) Vaginal Gels in the United States HIV-1 Infections | Phase 1 / Phase 2 | 2009-07-06 |
| Completed | An Expanded Safety Study of Dapivirine Gel 4789 in Africa HIV Infections, Acquired Immunodeficiency Syndrome, Healthy | Phase 1 / Phase 2 | 2009-07-01 |
| Completed | A Phase I Pharmacokinetics and Safety Study of Two Dapivirine Intravaginal Gels HIV Infections | Phase 1 | 2007-11-01 |
| Completed | A Pharmacokinetic Study of Dapivirine Vaginal Rings in Belgium HIV Infections | Phase 1 | 2007-05-01 |
| Completed | A Safety and Acceptability Study of a Vaginal Ring Microbicide Delivery Method HIV Infections | EARLY_Phase 1 | 2007-03-01 |
| Completed | A Safety Study of Dapivirine (TMC120) Vaginal Microbicide Gel in Belgium HIV Infections, HIV-1 | Phase 1 / Phase 2 | 2005-12-01 |
| Completed | A Study to Assess the Pharmacokinetics of Dapivirine (TMC120) Vaginal Microbicide Gel HIV Infections | Phase 1 | 2005-11-01 |
| Completed | A Safety and Tolerability Study of Dapivirine (TMC120) Vaginal Microbicide Gel HIV Infections | Phase 1 / Phase 2 | 2005-10-01 |
| Completed | Safety and Feasibility Study of Dapivirine (TMC120) Vaginal Ring in Belgium HIV Infections | Phase 1 | 2005-07-01 |
| Completed | Feasibility Study of a Vaginal Ring for Delivery of TMC120 (Dapivirine) HIV Infections | Phase 1 | 2004-10-01 |
| Withdrawn | A Safety Study of Dapivirine (TMC120) Vaginal Microbicide Gel in South Africa HIV Infections | Phase 1 / Phase 2 | — |