| Withdrawn | A Study to Assess Efficacy and Safety of Oral Tazemetostat in Adult Participants With Relapsed/Refractory Foll Follicular Lymphoma, Refractory Follicular Lymphoma | Phase 2 | 2025-09-02 |
| Terminated | A Study of the Safety, Tolerability and Effectiveness of EZM0414 (IPN60210) Investigative Product in Participa Multiple Myeloma, Refractory, Diffuse Large B-Cell Lymphoma, Diffuse Large B Cell Lymphoma Refractory | Phase 1 | 2022-05-31 |
| Withdrawn | A Study of Tazemetostat in Combination With Various Treatments in Participants With Blood Cancer. Relapsed Hematologic Malignancy, Refractory Hematologic Malignancy | Phase 1 / Phase 2 | 2021-12-22 |
| Terminated | SYMPHONY-2, A Trial to Examine Combination of Tazemetostat With Rituximab in Subjects With Relapsed/Refractory Follicular Lymphoma | Phase 2 | 2020-12-15 |
| Recruiting | A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma | Phase 3 | 2020-06-11 |
| Completed | Effects of Itraconazole and Rifampin on the Blood Tazemetostat Levels All Malignancies, Advanced Malignancies, Hematologic Malignancy | Phase 1 | 2020-04-23 |
| Terminated | A Study to Compare the Blood Levels and Safety of Tazemetostat in Participants With Advanced Cancer and Modera Hepatic Impairment, Advanced Malignant Solid Tumor | Phase 1 | 2020-01-15 |
| Terminated | Tazemetostat in Combination With Doxorubicin as Frontline Therapy for Advanced Epithelioid Sarcoma Advanced Soft-tissue Sarcoma, Advanced Epithelioid Sarcoma | Phase 1 | 2019-12-19 |
| Terminated | A Study of Tazemetostat With Enzalutamide or Abiraterone/Prednisone in Participants With Advanced Prostate Can Metastatic Prostate Cancer, Metastatic Castration-resistant Prostate Cancer | Phase 1 / Phase 2 | 2019-11-18 |
| Completed | Open-Label, Multi-Center, Two-Part, Ph1 Study to Characterize the PKs of an Intravenous Micro-Dose of [14C]-Ta Diffuse Large B Cell Lymphoma, Primary Mediastinal Lymphoma, Mantle-Cell Lymphoma | Phase 1 | 2018-06-20 |
| Completed | Epithelioid Sarcoma Natural History Study Epithelioid Sarcoma | — | 2018-06-04 |
| Completed | Open-Label, Multicenter, Two-Part, Phase 1 Study to Characterize Effects of a Moderate CYP3A Inhibitor on PK o Diffuse Large B Cell Lymphoma, Primary Mediastinal Lymphoma, Mantle Cell Lymphoma | Phase 1 | 2017-03-27 |
| Completed | A Study to Assess Long-term Safety of Tazemetostat in Adult Participants of All Ages With Any Disease Treated Diffuse Large B-cell Lymphoma (DLBCL), Follicular Lymphoma (FL), Synovial Sarcoma | Phase 1 / Phase 2 | 2016-08-30 |
| Completed | Study of the EZH2 Inhibitor Tazemetostat in Malignant Mesothelioma Mesothelioma, BAP1 Loss of Function | Phase 2 | 2016-07-01 |
| Completed | EZH2 Inhibitor Tazemetostat in Pediatric Subjects With Relapsed or Refractory INI1-Negative Tumors or Synovial Rhabdoid Tumors, INI1-negative Tumors, Synovial Sarcoma | Phase 1 | 2016-01-07 |
| Completed | A Study of Tazemetostat in Adult Participants With Soft Tissue Sarcoma Malignant Rhabdoid Tumors (MRT), Rhabdoid Tumors of the Kidney (RTK), Atypical Teratoid Rhabdoid Tumors (ATRT) | Phase 2 | 2015-12-22 |
| Completed | A Phase 1 Dose Escalation and Expanded Cohort Study of EPZ-5676 in the Treatment of Pediatric Patients With Re Leukemia, Acute Myeloid Leukemia, Acute Lymphocytic Leukemia | Phase 1 | 2014-05-01 |
| Completed | Study of Tazemetostat as Single Agent in Solid Tumors or B-cell Lymphomas and in Combination With Prednisolone B-cell Lymphomas (Phase 1), Advanced Solid Tumors (Phase 1), Diffuse Large B-cell Lymphoma (Phase 2) | Phase 1 / Phase 2 | 2013-06-13 |
| Completed | A Phase 1, Open-Label, Dose-Escalation & Expanded Cohort, Continuous IV Infusion, Multi-center Study of the Sa Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome | Phase 1 | 2012-09-01 |
| No Longer Available | Tazemetostat Expanded Access Program for Adults With Epithelioid Sarcoma Epithelioid Sarcoma | — | — |
| No Longer Available | Tazemetostat Expanded Access Program for Adults With Solid Tumors Epithelioid Sarcoma (Ex-US Only), Spindle Cell Sarcoma, Sinonasal Carcinoma | — | — |