| Recruiting | Safety, Tolerability, and Pharmacokinetics of DCR-PDL1 in Adults With Solid Tumors Solid Tumors, Adult | Phase 1 | 2024-05-29 |
| Completed | A Study of DCR-STAT3 in Adults With Solid Tumors Solid Tumor, Adult, Refractory Tumor | Phase 1 | 2023-08-14 |
| Completed | Phase 1b Study of DCR-AUD in Healthy Volunteers Alcohol Use Disorder | Phase 1 | 2023-01-29 |
| Completed | Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function Primary Hyperoxaluria, Primary Hyperoxaluria Type 1, Primary Hyperoxaluria Type 2 | Phase 2 | 2022-02-22 |
| Withdrawn | An Extension Study of Belcesiran in Patients With Alpha-1 Antitrypsin Deficiency Associated Liver Disease (AAT Alpha 1-Antitrypsin Deficiency | Phase 2 | 2021-12-01 |
| Completed | Study of DCR-AUD in Healthy Volunteers Alcohol Use Disorder (AUD) | Phase 1 | 2021-09-21 |
| Completed | Natural History of Patients With PH3 and a History of Stone Events Primary Hyperoxaluria Type 3 | — | 2021-09-09 |
| Recruiting | Safety & Efficacy of DCR-PHXC in Patients With PH1 and ESRD Primary Hyperoxaluria Type 1, End Stage Renal Disease | Phase 2 | 2021-04-15 |
| Terminated | A Study of Belcesiran in Patients With AATLD Alpha 1-Antitrypsin Deficiency | Phase 2 | 2021-02-12 |
| Completed | Study to Evaluate Safety, Tolerability, PK and PD of DCR-PHXC in PH Type 3 Patients Primary Hyperoxaluria Type 3 | Phase 1 | 2020-09-14 |
| Completed | Study of DCR-A1AT in Healthy Adult Volunteers Alpha 1-Antitrypsin Deficiency | Phase 1 | 2019-10-24 |
| Active Not Recruiting | Long Term Extension Study in Patients With Primary Hyperoxaluria Primary Hyperoxaluria Type 1 (PH1), Primary Hyperoxaluria Type 2 (PH2), Kidney Diseases | Phase 3 | 2019-07-09 |
| Completed | Study of Safety and Tolerability of DCR HBVS Hepatitis B, Chronic | Phase 1 | 2018-12-28 |
| Completed | Study of DCR-PHXC-101 in Normal Healthy Volunteers and Patients With Primary Hyperoxaluria Primary Hyperoxaluria | Phase 1 | 2017-12-06 |
| Terminated | A Study of DCR-PH1 in Patients With Primary Hyperoxaluria Type 1 (PH1) Primary Hyperoxaluria Type 1 | Phase 1 | 2016-05-13 |
| Terminated | Phase Ib/2, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Hepatocellular Carcinoma Hepatocellular Carcinoma | Phase 1 / Phase 2 | 2015-01-27 |
| Terminated | Phase I, Multicenter, Dose Escalation Study of DCR-MYC in Patients With Solid Tumors, Multiple Myeloma, or Lym Solid Tumors, Multiple Myeloma, Non-Hodgkins Lymphoma | Phase 1 | 2014-04-01 |
| No Longer Available | Treatment of Primary Hyperoxaluria Type 1 With Nedosiran Primary Hyperoxaluria Type 1 (PH1) | — | — |