| Terminated | Study to Evaluate the Efficacy and Safety of Oral Difelikefalin for Moderate to Severe Pruritus in Subjects Wi Pruritus, Notalgia Paresthetica | Phase 2 / Phase 3 | 2023-08-01 |
| Terminated | CR845-310302: A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Chronic Kidney Diseases, Pruritus | Phase 3 | 2022-08-26 |
| Terminated | Study to Evaluate the Efficacy and Safety of Oral Difelikefalin as Adjunct Therapy to a Topical Corticosteroid Pruritus, Atopic Dermatitis | Phase 3 | 2022-08-16 |
| Terminated | A Study to Evaluate the Safety and Efficacy of Difelikefalin in Advanced Chronic Kidney Disease Patients With Chronic Kidney Diseases, Pruritus | Phase 3 | 2022-05-17 |
| Completed | Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Sub Pruritus, Notalgia Paresthetica | Phase 2 | 2021-01-11 |
| Completed | CR845-100303: Study to Assess the Potential of Physical Withdrawal From Intravenous CR845 (Difelikefalin) in H Hemodialysis | Phase 1 | 2019-12-31 |
| Completed | Study to Evaluate the Efficacy and Safety of Oral Difelikefalin (CR845) for Moderate to Severe Pruritus in Sub Pruritus, Atopic Dermatitis | Phase 2 | 2019-06-29 |
| Terminated | Study to Evaluate the Safety and Efficacy of Oral CR845 (Difelikefalin) in Patients With Primary Biliary Chola Cholestatic Pruritus | Phase 2 | 2019-06-25 |
| Completed | Study to Investigate the Effects of Single Intravenous Doses of Difelikefalin (CR845) on the QTc Interval in H Healthy | Phase 1 | 2019-06-20 |
| Completed | CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Modera Uremic Pruritus | Phase 3 | 2019-05-06 |
| Completed | Study to Evaluate the Pharmacokinetics and Metabolism of [14C] CR845 (Difelikefalin) in Patients With End Stag Hemodialysis, Healthy | Phase 1 | 2019-01-17 |
| Completed | CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Mode Uremic Pruritus | Phase 3 | 2018-07-17 |
| Completed | A Study to Evaluate the Safety and Efficacy of CR845 in Chronic Kidney Disease Patients With Moderate-to-Sever Chronic Kidney Diseases, Pruritus | Phase 2 | 2018-07-05 |
| Completed | A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Uremic Pruritus | Phase 3 | 2018-02-20 |
| Completed | Extension Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Uremic Pruritus | Phase 3 | 2017-08-14 |
| Completed | A Study Evaluating Pain Relief and Safety of Orally Administered CR845 in Patients With Osteoarthritis of Hip Osteoarthritis, Hip, Osteoarthritis, Knee, Arthritis | Phase 2 | 2016-09-01 |
| Completed | Study to Evaluate IV CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus Uremic Pruritus | Phase 2 / Phase 3 | 2016-06-01 |
| Completed | A Study Evaluating the Overall Pain Relief and Safety of Intravenous (IV) CR845 in Patients Undergoing Abdomin Post Abdominal Surgery Pain | Phase 2 / Phase 3 | 2015-09-01 |
| Completed | A Study of the Safety and Effectiveness of Orally Administered CR845 in Patients With Osteoarthritis of the Hi Osteoarthritis | Phase 2 | 2015-08-01 |
| Completed | Safety and Pharmacokinetics of IV CR845 in Hemodialysis Patients, and Its Efficacy in Patients With Uremic Pru Pruritus, Uremic Pruritus | Phase 2 | 2014-07-01 |
| Completed | A Phase 2 Study to Evaluate Analgesic Effect of IV CR845 For Pain Following Bunionectomy Surgery Acute Pain | Phase 2 | 2013-05-01 |
| Completed | Study to Evaluate Analgesic Effect of IV Administration of Kappa Agonist CR845 For Hysterectomy Surgery Postoperative Pain | Phase 2 | 2011-07-01 |
| Completed | Study to Evaluate Analgesic Effect of Intravenous Administration of Kappa Agonist CR845 After Hysterectomy Sur Acute Pain | Phase 2 | 2009-03-01 |
| Approved For Marketing | Intermediate-Size Patient Population Expanded Access Program for Intravenous Difelikefalin Uremic Pruritus | — | — |