| Not Yet Recruiting | TEGSEDI Pregnancy Surveillance Program Hereditary Transthyretin-mediated Amyloidosis With Polyneropathy, Pregnancy | — | 2025-12-01 |
| Recruiting | A Non-interventional Cohort Safety Study of Patients With hATTR-PN Hereditary Transthyretin Amyloidosis With Polyneuropthy | — | 2021-09-21 |
| Terminated | A Study to Characterize Adverse Events Occurring Within One Day of TEGSEDI Administration to Adult Participant Hereditary Transthyretin Amyloidosis With Polyneuropthy | Phase 4 | 2021-01-21 |
| Completed | Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Partial Lipodystrophy (FPL) Familial Partial Lipodystrophy | Phase 2 | 2018-06-15 |
| Withdrawn | Study of AKCEA-ANGPTL3-LRX (ISIS 703802) in Patients With Homozygous Familial Hypercholesterolemia (HoFH) Homozygous Familial Hypercholesterolemia | Phase 2 | 2018-04-12 |
| Completed | Study of ISIS 681257 in Patients With Renal Impairment Compared to Healthy Patients Renal Impairment | Phase 1 | 2018-03-20 |
| Completed | Study of ISIS 678354 (AKCEA-APOCIII-LRx) in Participants With Hypertriglyceridemia and Established Cardiovascu Hypertriglyceridemia, Cardiovascular Diseases | Phase 2 | 2018-01-30 |
| Completed | Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Clopidogrel Elevated Lipoprotein(a), Cardiovascular Diseases | Phase 1 | 2017-12-28 |
| Completed | Phase 2 Study of AKCEA-ANGPTL3-LRx (ISIS 703802) in Participants With Familial Chylomicronemia Syndrome (FCS) Familial Chylomicronemia Syndrome, Lipoprotein Lipase Deficiency, Hyperlipoproteinemia Type 1 | Phase 2 | 2017-12-21 |
| Completed | Study of ISIS 703802 in Participants With Hypertriglyceridemia, Type 2 Diabetes Mellitus, and Nonalcoholic Fat NAFLD, Diabetes Mellitus, Type 2, Hypertriglyceridemia | Phase 2 | 2017-12-21 |
| Completed | Drug-drug Interaction Study to Evaluate the Effect of ISIS 681257 on Warfarin Elevated Lipoprotein(a), Cardiovascular Diseases | Phase 1 | 2017-12-15 |
| Completed | Phase 2 Study of ISIS 681257 (AKCEA-APO(a)-LRx) in Participants With Hyperlipoproteinemia(a) and Cardiovascula Elevated Lipoprotein(a), Cardiovascular Disease | Phase 2 | 2017-03-07 |
| Terminated | The BROADEN Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familial Partial Li Familial Partial Lipodystrophy | Phase 2 / Phase 3 | 2015-12-28 |
| Completed | The Approach Open Label Study: A Study of Volanesorsen (Formerly IONIS-APOCIIIRx) in Participants With Familia Familial Chylomicronemia Syndrome, Lipoprotein Lipase Deficiency, Hyperlipoproteinemia Type 1 | Phase 3 | 2015-12-23 |
| No Longer Available | Volanesorsen Early Access Program for Patients With Familial Chylomicronemia Syndrome (FCS) Familial Chylomicronemia | — | — |