| Not Yet Recruiting | A Study to Investigate Arbaclofen ER Tablets for the Treatment of Spasticity in Patients With Multiple Scleros NCT05179577 | RVL Pharmaceuticals, Inc. | Phase 3 |
| Recruiting | Shockwave for Elbow and Wrist Spasticity in People With Spinal Cord Injury NCT07501429 | Kessler Foundation | Phase 1 |
| Recruiting | Spinal Cord Stimulation for Children With Cerebral Palsy NCT07516067 | Martin Piazza | N/A |
| Recruiting | At Home Use of Stimulation Suits for Managing MS Symptoms NCT07202195 | Daphne Kos | N/A |
| Not Yet Recruiting | Effects Of Spiral Strapping Systems On Upper Limb Function In Unilateral Spastic Cerebral Palsy NCT07418710 | Abant Izzet Baysal University | N/A |
| Recruiting | Leg Stretching Using an Exoskeleton on Demand for People With Spasticity NCT05926596 | VA Office of Research and Development | N/A |
| Not Yet Recruiting | Correlation Between Diagnostic Nerve Block Response and Cryoneurolysis Outcome in Chronic Musculoskeletal Diso NCT07289984 | Universitair Ziekenhuis Brussel | N/A |
| Recruiting | Classification of Upper and Lower Limb Spasticity Patterns and Their Impact on Quality of Life in Patients Wit NCT07466823 | Marmara University | — |
| Recruiting | Effects of Low-level Laser Therapy on Spasticity and Gait Parameters in Chronic Stroke Patients With Spastic P NCT07273591 | Montiha Azeem | N/A |
| Completed | Static Versus Dynamic Splints for Wrist Spasticity in Stroke Patients NCT07301606 | University of Lahore | N/A |
| Not Yet Recruiting | Effectiveness of an Interprofessional Approach to the Treatment of Spasticity With Botulinum Toxin & Non-pharm NCT07160699 | Technical University of Bern | N/A |
| Completed | Does Anxiety Affect Balance, Spasticity and Function in Children With Cerebral Palsy NCT07346430 | Cairo University | — |
| Not Yet Recruiting | Predictors of Motor İmagery Performance in Cerebral Palsy NCT07002567 | Abant Izzet Baysal University | — |
| Not Yet Recruiting | Lateral Cord Stimulation as a New Treatment for Refractory Spastic Cerebral Palsy NCT02199015 | Juan Carlos M. Andreani MD | N/A |
| Not Yet Recruiting | Pilot Study on Muscle, Tendon, and Neural Changes Post-Botulinum Toxin Injections in Post-stroke Spastic Equin NCT06767631 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Not Yet Recruiting | Efficacy of Shock Wave Therapy in Post-Stroke Muscle Spasticity Management NCT06815328 | University of Oviedo | N/A |
| Enrolling By Invitation | Immediate Effects on Gait and Spasticity After the Use of Passive Kinesiotherapy Equipment in the Lower Limbs NCT06696040 | Fernanda Trubian | N/A |
| Active Not Recruiting | Early Botulinum Toxin for Muscle Stiffness Reduction in First-Time Stroke Patients: Improving Recovery and Ind NCT06811142 | Instituto Mexicano del Seguro Social | EARLY_Phase 1 |
| Completed | The Effect of Kinesiologic Taping on Trunk Control and Balance in Children With Cerebral Palsy NCT07188961 | Istanbul Rumeli University | N/A |
| Recruiting | Upper Limb Nerve Cryoneurolysis is Non Inferior to the Usual Care and Has Therapeutic Add Value in Dealing Wit NCT06782464 | Centre National de Rééducation Fonctionnelle et de Réadaptation | N/A |
| Completed | Effects Of Dry Needling On Mobility Among Children With Cerebral Palsy NCT06661421 | Riphah International University | N/A |
| Completed | Definition, Assessment and Treatment of Spasticity According to Physiotherapists and Occupational Therapists i NCT06956534 | Universiteit Antwerpen | — |
| Completed | Effect of Callisthenic Training on Mobility and ADL Performance in Spastic Diplegic Cerebral Palsy Patients NCT06966076 | Foundation University Islamabad | N/A |
| Completed | Additional Effects of Dry Needling With PNF on Spasticity and Functional Performance in Stroke NCT07013942 | Foundation University Islamabad | N/A |
| Terminated | The Influence of Dry Needling for Hypertonia and Spasticity Treatment on Neuropathic Pain in Lower Extremity o NCT06954688 | Universiteit Antwerpen | N/A |
| Recruiting | Additional Effects of Kinesio-Taping Along with Conservative Physical Therapy on Upper Limb Function, Range of NCT06674057 | Foundation University Islamabad | N/A |
| Recruiting | Dry Needling in Multiple Sclerosis NCT06394310 | University of Kansas Medical Center | N/A |
| Completed | Nerve Root Block in Spasticity NCT06868342 | Walton Centre NHS Foundation Trust | N/A |
| Completed | Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Part NCT06150729 | AbbVie | — |
| Completed | Ultrasound-Guided Versus Anatomically Guided Botulinum Toxin Injection in Spasticity in Adults in Tanta Univer NCT06941883 | Tanta University | — |
| Unknown | Exopulse Mollii Suit, Motor Functions & CP Children With Cerebral Palsy NCT05885139 | Exoneural Network AB | N/A |
| Recruiting | Neurosurgical Outcome Network NCT06724029 | Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta | — |
| Recruiting | Cryoneurolysis for Knee and Shoulder Pain in an Inpatient Setting NCT05674604 | Vancouver Island Health Authority | — |
| Not Yet Recruiting | "Epidural Spinal Cord Stimulation: Addressing Spasticity and Motor Function" NCT05422716 | Kessler Foundation | N/A |
| Unknown | Phase II Study to Assess Safety, Pharmacokinetics and Efficacy of SL-1002 for Limb Spasticity NCT05311215 | Saol Therapeutics Inc | Phase 2 |
| Active Not Recruiting | Ultrasonograpy in Hemiplegic Patients NCT06706063 | Afyonkarahisar Health Sciences University | — |
| Unknown | Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Upper Limb Spasticity NCT04815967 | Supernus Pharmaceuticals, Inc. | Phase 2 / Phase 3 |
| Recruiting | A Study to Assess the Safety and Efficacy of IPN10200 in Adult Participants With Upper Limb Spasticity. NCT04752774 | Ipsen | Phase 1 / Phase 2 |
| Completed | Retrospective Real-Life Study From One Brazilian Reference Center Assessing Long-Term Experience In The Treatm NCT04446702 | Ipsen | — |
| Recruiting | Neuroimmunology Registry and Biobank NCT06958341 | Charite University, Berlin, Germany | — |
| Completed | Study Assessing Adult Subjects Affected With Upper and/or Lower Limb Spasticity Treated With Botulinum Neuroto NCT04340336 | Ipsen | — |
| Completed | Extracorporeal Shock Wave Therapy on Wrist and Hand Functions in Spastic Chronic Stroke Patients NCT04312581 | Tanta University | N/A |
| Unknown | Efficacy and Safety Study of MYOBLOC® in the Treatment of Adult Lower Limb Spasticity NCT04099667 | Supernus Pharmaceuticals, Inc. | Phase 2 / Phase 3 |
| Unknown | miR-142-3p as Potential Biomarker of Synaptopathy in MS NCT03999788 | Neuromed IRCCS | N/A |
| Unknown | CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITY NCT04673240 | Università degli Studi del Piemonte Orientale Amedeo Avogadro | — |
| Enrolling By Invitation | Neuromusculoskeletal Modeling of Muscle Spasticity NCT05447299 | Region Stockholm | — |
| Completed | Dry Needling and Bobath Treatment Clinical Effects Focused on Stroke Patients NCT03906305 | Universidad Rey Juan Carlos | N/A |
| Completed | Effectiveness of Dry Needling (DNHS Technique) in Patients With Chronic Stroke NCT03546517 | Universidad San Jorge | N/A |
| Completed | Imaging of 3D Innervation Zone Distribution in Spastic Muscles From High-density Surface EMG Recordings NCT03302741 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | Spinal Cord Stimulation to Augment Activity Based Therapy NCT03240601 | Shepherd Center, Atlanta GA | N/A |
| Unknown | Modulation of H-reflex After Application of Electric Currents in Healthy People NCT02718989 | University of Castilla-La Mancha | N/A |
| Completed | Comparing the Effect of Focused and Radial Extracorporeal Shock Waves on Post-stroke Hypertonia NCT03129529 | Mackay Memorial Hospital | N/A |
| Completed | Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal NCT02334683 | Icahn School of Medicine at Mount Sinai | N/A |
| Completed | Developing and Testing a Comprehensive MS Spasticity Management Program NCT02170779 | VA Office of Research and Development | Phase 2 |
| Unknown | The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients NCT02470325 | Wolfson Medical Center | Phase 2 |
| Completed | Study on the Use of Botulinum Toxin Type A in the Treatment of Chronic Post-stroke Spastic Patients NCT02390206 | Ipsen | — |
| Completed | Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment of Post-Stroke Spasticity NCT02268461 | University of Minnesota | N/A |
| Completed | Importance of the Current Density in TENS NCT02718690 | University of Castilla-La Mancha | N/A |
| Completed | Effects of DNHS Technique in the Treatment of Upper Limb Spasticity and Function in Stroke NCT02291159 | Universidad San Jorge | N/A |
| Terminated | Functional MRI and DTI in the Preoperative Assessment of Dystonia NCT02877836 | University Hospital, Montpellier | N/A |
| Completed | Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cros NCT02400619 | Xavi Vidal Novellas | Phase 1 |
| Completed | The Effect of Extracorporeal Shock Wave Therapy on Spasticity NCT02221011 | Tri-Service General Hospital | N/A |
| Completed | ETREAT Study on Effectiveness of Botulinum Toxin Type A Injections to Treat Post-stroke Upper and/or Lower Lim NCT02275312 | Ipsen | — |
| Completed | Extracorporeal Shock Wave Therapy (ESWT) for the Treatment of Spasticity in Persons With Spinal Cord Injury NCT02203994 | Swiss Paraplegic Research, Nottwil | N/A |
| Completed | Study of SPARC1103 in Subjects With Spasticity NCT02027025 | Sun Pharma Advanced Research Company Limited | Phase 2 |
| Unknown | The Effect of Whole Body Vibration on Spasticity in Persons With Spinal Cord Injury NCT02127606 | Kessler Foundation | N/A |
| Completed | Dose-response Study of Efficacy and Safety of Botulinum Toxin Type A to Treat Spasticity of the Arm(s) or of A NCT02002884 | Merz Pharmaceuticals GmbH | Phase 3 |
| Unknown | Upper Extremity Rehabilitation Using Robot and Botulinum Toxin NCT02228863 | National Rehabilitation Center, Seoul, Korea | Phase 4 |
| Unknown | Rectus Femoris Tenotomy Versus Botulinum Toxin A for Stiff Knee Gait After Stroke NCT02114736 | University Hospital of Mont-Godinne | Phase 4 |
| Completed | Efficacy and Cost-effectiveness of Spasticity Treatment With Multifocal TENS NCT02261142 | Linkoeping University | N/A |
| Completed | A Randomized, Double Blind, Multi-center, Active Drug Controlled, Phase III Clinical Trial to Compare the Safe NCT01945684 | Daewoong Pharmaceutical Co. LTD. | Phase 3 |
| Completed | Phase III Study of Botulax® to Treat Post Stroke Upper Limb Spasticity NCT01915459 | Hugel | Phase 3 |
| Completed | Safety Study of SPARC1104 NCT01797185 | Sun Pharma Advanced Research Company Limited | Phase 3 |
| Completed | A Study to Define the ECG Effects of Tizanidine Compared to Placebo and the Positive Control, Moxifloxacin, in NCT01839279 | Acorda Therapeutics | Phase 2 |
| Completed | Reliability of an Algorithm to Diagnose Spasticity NCT01644123 | Vanderbilt University | — |
| Completed | One Year, Open Label, Dose Escalation Long-term Safety Study in Multiple Sclerosis (MS) Subjects With Spastici NCT01844232 | RVL Pharmaceuticals, Inc. | Phase 3 |
| Completed | Prevalence of Spasticity in Veterans Living in a Long-term Care Facility NCT01879449 | Vanderbilt University | — |
| Completed | Efficacy and Safety of SPARC0921 in Subjects With Spasticity NCT01457352 | Sun Pharma Advanced Research Company Limited | Phase 3 |
| Completed | Efficacy Study of Arbaclofen to Treat Spasticity in Multiple Sclerosis NCT01743651 | RVL Pharmaceuticals, Inc. | Phase 3 |
| Terminated | Long-term Surveillance of the MedStream Programmable Infusion System NCT01712087 | Codman & Shurtleff | — |
| Withdrawn | Surface EMG Biofeedback for Children With Cerebral Palsy NCT01681888 | University of Southern California | N/A |
| Completed | Use of Ultrasound in Injections of Botulinum Toxin NCT02566837 | University Hospital, Toulouse | N/A |
| Completed | A Randomized Study of Sativex on Cognitive Function and Mood: Multiple Sclerosis Patients NCT01964547 | Jazz Pharmaceuticals | Phase 4 |
| Completed | DTI Study of the Influence of Physiotherapy on Distribution of BoNT in Spastic Muscle NCT01523210 | Kirsten Elwischger, MD | — |
| Completed | Adult Subjects Suffering From Lower Limb Spasticity Following Stroke NCT01444794 | Ipsen | — |
| Completed | MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity NCT01313767 | Medy-Tox | Phase 3 |
| Unknown | A Prospective Study of Spasticity in Individuals With Multiple Sclerosis NCT01111435 | Fraser, Cira, Ph.D., RN, ACNS-BC | — |
| Withdrawn | Continuous Intrathecal Baclofen Infusion for Chronic Spasticity NCT01051128 | Flowonix Medical | Phase 3 |
| Completed | Neuro-orthopaedic Surgery in the Treatment of the Spastic Equinovarus Foot NCT01265238 | University Hospital of Mont-Godinne | — |
| Completed | Kinesiotaping the Hand in Cerebral Palsy NCT02073513 | Hacettepe University | N/A |
| Completed | A Study With IPX056 in Subjects With Spasticity Associated With Multiple Sclerosis NCT00914290 | Impax Laboratories, LLC | Phase 2 |
| Completed | Trial Comparing Two Commercial Formulations of Botulinum Toxin Type A in the Treatment of Spasticity NCT00819065 | Hospital de Clinicas de Porto Alegre | Phase 3 |
| Completed | Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients NCT01817816 | Changhua Christian Hospital | N/A |
| Completed | Oral Baclofen Pharmacokinetics and Pharmacodynamics in Children With Spasticity NCT00607542 | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) | Phase 1 / Phase 2 |
| Terminated | One Year Extension Study To Protocol C2/5/TZ:MS-05 NCT00464958 | Teva GTC | Phase 1 / Phase 2 |
| Terminated | Energy Costs of Spasticity in Spinal Cord Injury: A Pilot Investigation NCT00572845 | Virginia Commonwealth University | N/A |
| Completed | A Study of the Safety and Effectiveness of Sativex®, for the Relief of Symptoms of Spasticity in Subjects, Fro NCT00681538 | Jazz Pharmaceuticals | Phase 3 |
| Completed | Evaluate the Maintenance of Effect After Long-term Treatment With Sativex® in Subjects With Symptoms of Spasti NCT00702468 | Jazz Pharmaceuticals | Phase 3 |
| Completed | Use of EMG to Assess Clinical Hypertonia NCT00472914 | University of Southern California | — |
| Unknown | Validation of an Obstacle Course Used in Patients With Muscle Tightness NCT00776048 | Kessler Foundation | — |
| Completed | Prevalence of Spasticity in Adults With Mental Retardation Living in the Community NCT00282191 | Vanderbilt University | — |
| Completed | Power Wheelchair Joystick Use in Spastic Cerebral Palsy NCT00337688 | University of Pittsburgh | — |
| Terminated | Botox vs. Baclofen for Upper Limb Spasticity NCT00280280 | Vanderbilt University | Phase 1 |
| Completed | Optical Stimulation in Peripheral Nerves for Select Rhizotomy Procedures NCT00575536 | Vanderbilt University | — |
| Completed | Vanderbilt University Spasticity Management Program Evaluation Plan NCT00179114 | Vanderbilt University | Phase 4 |
| Completed | A Study of Sativex® for Relief of Spasticity in Subjects With Multiple Sclerosis. NCT00711646 | Jazz Pharmaceuticals | Phase 3 |
| Completed | A Study of the Long-term Safety of Sativex Use NCT01606137 | Jazz Pharmaceuticals | Phase 3 |
| Completed | Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity NCT00178646 | The University of Texas Health Science Center, Houston | Phase 4 |
| Completed | Dutch National ITB Study in Children With Cerebral Palsy NCT00367068 | Maastricht University | Phase 3 |
| Completed | A Long-term Safety Extension Study of Delta-9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) in Multiple Scl NCT01610687 | Jazz Pharmaceuticals | Phase 3 |
| Withdrawn | Phase 3, 28-week, Randomized, Double-blind, Placebo-controlled Safety and Efficacy Study of Nabiximols as an a NCT01868048 | GW Research Ltd | Phase 3 |