| Not Yet Recruiting | Venous Compression in Fontan NCT07220226 | University of Texas Southwestern Medical Center | N/A |
| Recruiting | Transcatheter Fontan Stenting: Impact on Hepatic Stiffness and Exercise Capacity NCT07073612 | Children's Hospital Los Angeles | — |
| Not Yet Recruiting | Impact of Early Fortini Initiation on Growth and Interstage Outcomes in Infants With Single Ventricle Physiolo NCT07087782 | Driscoll Children's Hospital | N/A |
| Recruiting | Fontan Fitness Trial NCT06918795 | Children's Hospital of Philadelphia | N/A |
| Recruiting | Extracellular Vesicle Micro RNA Profiling in Congenital Heart Disease: Fetal-Maternal Regulation in Neonatal T NCT06434207 | Boston Children's Hospital | — |
| Recruiting | PK/PD of Digoxin in Infants With SVHD NCT06613477 | Duke University | Phase 1 / Phase 2 |
| Recruiting | Association of Near Infrared Spectroscopy With Interstage Outcomes NCT06538571 | Advocate Hospital System | N/A |
| Recruiting | REHAB Fontan Failure: A Trial of Cardiac Rehabilitation NCT06150950 | Stanford University | N/A |
| Completed | Simple Non-invasive Breathing Device to Improve Pulmonary Flow Pusatility in Single Ventricle Post Fontan NCT05634226 | Tarek Alsaied | N/A |
| Withdrawn | Efficacy of Phosphodiesterase-type 5 Inhibitors in Patients With Univentricular Congenital Heart Disease NCT03997097 | University Hospital, Montpellier | Phase 3 |
| Recruiting | Adult Congenital Heart Disease International EValuation of the Effectiveness of SGLT2i Registry NCT06932081 | Leiden University Medical Center | — |
| Recruiting | Ventripoint Single Ventricle Study NCT05262907 | Duke University | N/A |
| Completed | Enhanced External Counterpulsation in Patients With Fontan Circulation NCT04956952 | Boston Children's Hospital | N/A |
| Completed | Virtual Remote Physiological Monitoring Program of Children With Heart Disease NCT05034354 | University of Alberta | N/A |
| Recruiting | An Integrated Prenatal and Postnatal Treatment Model for the Treatment of Newborns With Critical Congenital He NCT06768008 | Beijing Anzhen Hospital | — |
| Completed | Exercise Capacity in Patients With Fontan Procedure NCT05063903 | Hacettepe University | — |
| Completed | Correlation Between 3D Echocardiography and Cardiopulmonary Exercise Testing in Patients With Single Ventricle NCT05118152 | University Hospital, Montpellier | — |
| Completed | The PaTHS Descriptive Correlational Longitudinal Study NCT04785482 | Children's Mercy Hospital Kansas City | — |
| Recruiting | Fibrosis and the Fontan NCT04901975 | Children's Hospital of Philadelphia | Phase 1 / Phase 2 |
| Completed | Hemodynamic, Vascular and Muscular Parameters of Exercise Capacity in Single-Ventricle Patients With Fontan Pr NCT05011565 | Hacettepe University | — |
| Recruiting | Re-Energize Fontan NCT04195451 | Stanford University | N/A |
| Recruiting | Two-Year Study of the Safety and Efficacy of the Second-Generation Tissue Engineered Vascular Grafts NCT04467671 | Nationwide Children's Hospital | Phase 2 |
| Completed | Redesigning the Care Journey of Patients With Single-ventricle Congenital Heart Disease NCT04613934 | University of Texas at Austin | — |
| Recruiting | NIRS in Congenital Heart Defects - Correlation With Echocardiography NCT04106479 | McGill University Health Centre/Research Institute of the McGill University Health Centre | — |
| Unknown | Validation of Cardiac Magnetic Resonance Sequences in Patients With Single Ventricles NCT04017494 | Barbara Burkhardt | — |
| Enrolling By Invitation | Characterizing the Effect of Dopamine on Markers of Lymph Re-circulation in Fontan-associated Protein-losing E NCT03322345 | University of Michigan | — |
| Terminated | Colchicine in Postoperative Fontan Patients NCT03575572 | University of Michigan | Phase 2 / Phase 3 |
| Completed | The Effect of Fontan Fenestration Closure on Hepatic Stiffness NCT03481985 | Boston Children's Hospital | — |
| Completed | Clinical Characteristics and Associations of the "Good Fontan" Patient NCT03470428 | Boston Children's Hospital | — |
| Recruiting | ET1 Concentration, Metabolic Pathway Activation, and Pulmonary Blood Flow in Infants Undergoing Superior Cavo- NCT03404258 | University of Colorado, Denver | — |
| Unknown | Multimodality Biomarkers for Noninvasive Assessment of the Fontan Patient NCT03263312 | Maria Bano | N/A |
| Completed | Early Use of Vasopressin in Post-Fontan Management NCT03088345 | Medical College of Wisconsin | Phase 2 / Phase 3 |
| Completed | Use of Vasopressin Following the Fontan Operation NCT02975999 | Wake Forest University Health Sciences | Phase 2 / Phase 3 |
| Completed | Frailty in Children With Cardiac Disease NCT02999438 | Children's Mercy Hospital Kansas City | — |
| Completed | Effect of Carvedilol on Exercise Performance in Fontan Patients NCT02946892 | University of Texas Southwestern Medical Center | Phase 4 |
| Recruiting | Cardiac Stem/Progenitor Cell Infusion in Univentricular Physiology (APOLLON Trial) NCT02781922 | Metcela Inc. | Phase 3 |
| Completed | Inspiratory Muscle Therapy in Subjects With Fontan Circulations NCT03339466 | Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center | N/A |
| Withdrawn | Changes in Cerebral Oxygenation During Laparoscopy in Patients With Single Ventricle Anatomy NCT02614664 | Roby Sebastian | — |
| Terminated | Perioperative Treprostinil in Pediatric Patients Undergoing the Fontan Operation NCT02498444 | Stanford University | N/A |
| Completed | Fontan Imaging Biomarkers (FIB) Study NCT03119090 | Boston Children's Hospital | — |
| Completed | Improving Functional Capacity in Fontan Patients Through Inspiratory Muscle Training NCT01977222 | Boston Children's Hospital | N/A |
| Completed | Diffuse Myocardial Fibrosis in Fontan Patients NCT01929174 | Oregon Health and Science University | — |
| Completed | Cardiovascular, Pulmonary and Skeletal Muscle Evaluation Postoperative in Fontan Patients: Effects of Exercise NCT02283255 | University of Sao Paulo | N/A |
| Completed | Effect of Tadalafil on Exercise Capacity in Pediatric Fontan Patients NCT01291069 | University of Utah | Phase 1 |
| Completed | Transcoronary Infusion of Cardiac Progenitor Cells in Patients With Single Ventricle Physiology NCT01273857 | Okayama University | Phase 1 |
| Withdrawn | The Destination Therapy Evaluation for Failing Fontan Study NCT01149603 | Timothy Icenogle, MD | N/A |
| Completed | Single Ventricle Outcome NCT00308217 | Emory University | — |