| Not Yet Recruiting | Octreotide Microspheres for Preventing Pancreatic Fistula NCT07479784 | Shanghai Zhongshan Hospital | Phase 3 |
| Recruiting | Immunoparalysis After Pancreaticoduodenectomy NCT07144917 | Hospices Civils de Lyon | — |
| Recruiting | Prevention of Postoperative Pancreatic Fistula Following Pancreaticoduodenectomy by Preoperative Radiotherapy NCT07370987 | Assistance Publique - Hôpitaux de Paris | Phase 2 |
| Recruiting | Preoperative EUS Elastography for Pancreatic Texture and POPF Prediction After PD NCT07139236 | Minia University | — |
| Recruiting | Predictive Risk Factors for Pancreatic Fistula After Pancreaticoduodenectomy NCT07022015 | Minia University | N/A |
| Recruiting | Laparoscopic Pancreaticoduodenectomy NCT07009119 | Minia University | N/A |
| Recruiting | Reinforced Pancreaticojejunostomy With or Without glubran2 NCT06756074 | Minia University | Phase 2 |
| Recruiting | External Pancreatic Stent in Pancreaticojejunostomy NCT06743516 | Minia University | N/A |
| Completed | The Study of the Natural Way of Development of External Pancreatic Fistulas in Children with Necrotizing Pancr NCT06706440 | Moscow Regional Research and Clinical Institute (MONIKI) | — |
| Recruiting | Indocyanine Green Fluorescence in Evaluation of Pancreatic Remnant Perfusion. NCT06198400 | Charles University, Czech Republic | N/A |
| Recruiting | METabolomic and Immune PROfiling in the Development of Pancreatic Fistulas After cepHalic duodEnopancreatectom NCT06283160 | Centre Hospitalier Universitaire de Besancon | — |
| Terminated | eXtended Antibiotic Prophylaxis for Intermediate- and High-risk Glands After Pancreatoduodenectomy to Reduce C NCT05753735 | Case Comprehensive Cancer Center | Phase 2 |
| Unknown | Influence of Pancreatic Transection With CUSA on Postoperative Pancreatic Fistula Incidence (PANCUT) NCT06135012 | University Medical Centre Ljubljana | N/A |
| Not Yet Recruiting | Peritoneal Lavage on the Incidence of Pancreatic Fistula and Related Complications After Pancreatoduodenectomy NCT05657366 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | Distal Pancreatectomy Pancreatic Fistula Risk Prediction Model Validation Study NCT05737875 | University of Edinburgh | — |
| Recruiting | A Multicenter Randomized Controlled Study of External Pancreatic Duct Stents in Pancreaticoduodenectomy NCT05725590 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Recruiting | Comparison of Effectiveness of TissuePatchTM in Preventing Postoperative Pancreatic Fistula NCT05404256 | Xijing Hospital of Digestive Diseases | N/A |
| Unknown | One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy . NCT05387538 | Assiut University | N/A |
| Recruiting | Preoperative Endoscopic Pancreatic Stent for Distal Pancreatectomy NCT05297136 | Chinese University of Hong Kong | N/A |
| Unknown | Total pancrEaTectomy vs High-Risk Pancreatic anastomosiS NCT05212350 | Azienda Ospedaliera Universitaria Integrata Verona | N/A |
| Recruiting | Prognostic Factors in Periampullary Tumors and Cysts NCT05155878 | Umeå University | — |
| Completed | Effect of Trans-Nasal Afferent Loop Decompression on Post-Pancreaticoduodenectomy Pancreatic Fistula NCT04989868 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Completed | Clinically Relevant Pancreatic Fistula After Pancreaticoduodenectomy NCT05017207 | Vo Truong Quoc | — |
| Completed | Complication of Pancreatic Fistula and Bleeding After Pancreaticoduodenectomy in Treatment Periampullary Cance NCT04985071 | Vo Truong Quoc | — |
| Unknown | Prospective Snapshot Audit of Distal Pancreatectomy in Spain NCT04900012 | Hospital General Universitario de Alicante | — |
| Unknown | A Modified Omental Patch Work Decreases Pancreatic Fistula After Lpd NCT04704882 | Zhejiang Provincial People's Hospital | N/A |
| Unknown | Role of Preoperative Multislice Computed Tomography in Whipple's Operation. NCT04582461 | Assiut University | — |
| Unknown | Preoperative Radiotherapy in Patients at High Risk of Postoperative Pancreatic Fistula After Pancreatoduodenec NCT05641233 | Erasmus Medical Center | Phase 1 / Phase 2 |
| Completed | Early Drain Removal Versus Standard Drain Management After Distal Pancreatectomy (Early-Dist) NCT04609137 | IRCCS San Raffaele | N/A |
| Terminated | ERAS Protocol in Pancreaticoduodenectomy and Total Pancreatectomy NCT03757455 | Tampere University Hospital | N/A |
| Unknown | Validations of New cut-of for the Stratification of Postoperative Complications,Drains Management NCT04380506 | Campus Bio-Medico University | N/A |
| Unknown | Intravenous Human Albumin In Improving Pancreaticoduodenectomy Outcomes NCT04418739 | Universiti Kebangsaan Malaysia Medical Centre | Phase 2 |
| Completed | Post-Operative Acute Pancreatitis After Pancreaticoduodenectomy NCT04917172 | Azienda Ospedaliera Universitaria Integrata Verona | — |
| Active Not Recruiting | Monitoring of patIents With Microdialysis Following Pancreaticoduodenectomy NCT03631173 | Oslo University Hospital | N/A |
| Unknown | Prophylactic Pancreatic Stent for the Prevention of Post Operative Pancreatic Fistula NCT03822676 | Peking Union Medical College Hospital | N/A |
| Completed | Trans-drain Occlusion for Postoperative Pancreatic Fistula- A Double Blind Randomized Clinical Trial NCT03800940 | National Taiwan University Hospital | N/A |
| Unknown | Greater Omentum Binding to the Pancreatic Stump to Prevent Pancreatic Fistula Following Distal Pancreatectomy NCT03752086 | Tongji Hospital | N/A |
| Unknown | Biodegradable Pancreatic Stents for the Prevention of Postoperative Pancreatic Fistula After Cephalic Pancreat NCT04783831 | Hospital Universitario Virgen de la Arrixaca | — |
| Unknown | Identifing Risk Factors for Pancreaticojejunostomy Leakage Following Pancreaticoduodenectomy NCT04798560 | Dimitrios Vouros | — |
| Unknown | Modified Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy NCT03600584 | Nanjing Medical University | N/A |
| Unknown | Comparison Between Two Methods of Pancreatic Transection in Distal Pancreatectomy NCT03880773 | Azienda Ospedaliera Universitaria Integrata Verona | N/A |
| Completed | Somatostatin Prevent Post-operation Pancreatic Fistula in Intermediate Risk Patients After Pancreaticoduodenec NCT03349424 | Peking Union Medical College Hospital | Phase 4 |
| Completed | Use of Hemopatch as a Sealant at the Pancreaticojejunostomy After Pancreatoduodenectomy NCT03419676 | Hospital Miguel Servet | Phase 3 |
| Completed | A Phase II Trial of Lanreotide for the Prevention of Postoperative Pancreatic Fistula NCT03174353 | University of Washington | Phase 2 |
| Completed | Buttressed Pancreatico-Gastrostomy for Soft Pancreas With Small Diameter Pancreatic Duct in Whipple Procedure NCT05682768 | South Valley University | — |
| Unknown | Incidence of Pancreatic Fistula After Radical Gastrectomy NCT03391687 | Shanghai Zhongshan Hospital | — |
| Completed | Risk Factors for Clinically Relevant Postoperative Pancreatic Fistula NCT05687825 | South Valley University | — |
| Unknown | A Prospective Randomized Trial of Efficacy of Stump Closure for Distal Pancreatectomy NCT03201653 | National Taiwan University Hospital | N/A |
| Completed | Technical Strategies for Pancreatic Fistula Prevention After Pancreaticoduodenectomy in High-risk Pancreatic R NCT03212196 | Azienda Ospedaliera Universitaria Integrata Verona | N/A |
| Unknown | Trial of Omental Roll-up Technique on Pancreato-jejunostomy Anastomosis for Reducing Perioperative Complicatio NCT03083938 | Mahidol University | N/A |
| Completed | Risk Factors for Post Whipple Pancreatic Fistula NCT05014425 | Assiut University | — |
| Completed | Study of Pancreatic Enzymes in the Drains as Early Biomarkers of Post-operative Pancreatic Fistula and Its Cli NCT02784990 | Centre Hospitalier Universitaire Dijon | — |
| Active Not Recruiting | HYPAR Trial - Hydrocortisone vs. Pasireotide in Reducing Pancreatic Surgery Complications NCT02775227 | Helsinki University Central Hospital | Phase 4 |
| Completed | Different Stapler Cartridge For Pancreatic Stump Texture To Prevent Pancreatic Fistula NCT02790333 | Yi-Ping Mou | N/A |
| Unknown | One-layer Versus Two-layer Duct-to-mucosa Pancreaticojejunostomy After Pancreaticoduodenectomy NCT02511951 | The Second Hospital of Anhui Medical University | Phase 3 |
| Unknown | Ultrasound Elastography for Prediction of Postoperative Pancreatic Fistula NCT02589379 | University of Zurich | — |
| Completed | Treatment of the Pancreatic Stump With Neoprene®-Based Glue After High-risk Pancreatoduodenectomy NCT03738787 | Fondazione IRCCS Istituto Nazionale dei Tumori, Milano | Phase 2 |
| Unknown | Application and Optimization of the International Study Group of Pancreatic Surgery (ISGPS) Definition and Gra NCT05657327 | West China Hospital | — |
| Completed | Early Detection of Anastomotic Leakage by Microdialysis Catheters NCT03627559 | Oslo University Hospital | — |
| Completed | Pancreaticogastrostomy for High-Risk Pancreas NCT04724174 | Institut Paoli-Calmettes | — |
| Terminated | Prospective Trial Evaluating the Effect of Closed Suction Drainage Versus Straight Drainage After Distal Pancr NCT02343302 | Johns Hopkins University | N/A |
| Completed | Use of Polyethylene Glycolic Acid or Tachocomb to Prevent Pancreatic Fistula Following Distal Pancreatectomy NCT01550406 | Seoul National University Hospital | Phase 4 |
| Completed | Evaluation of a Novel Pancreaticojejunostomy Technique for Pancreaticoduodenectomy NCT01696903 | Karolinska Institutet | N/A |
| Completed | Effects of Intraarterial Octreotide on Pancreatic Texture NCT01400100 | St. Josef Hospital Bochum | N/A |
| Completed | Role of Octreotide in Preventing Pancreatic Fistula After Pancreaticoduodenectomy (PD) in Patients With Soft P NCT01301222 | PVS Memorial Hospital | Phase 4 |
| Unknown | Comparison of Feasibility Between Internal and External Pancreatic Drainage in Pancreaticoduodenectomy NCT01023594 | Seoul National University Hospital | N/A |
| Completed | Isolated Roux Loop Versus Conventional Pancreaticojejunostomy Following Pancreaticoduodenectomy NCT03671031 | Inonu University | — |
| Unknown | An Evaluation of a New Technique Utilizing a Biologic Glue and Tissue Patch to Seal the Cut Edge of the Pancre NCT00889213 | Thomas Jefferson University | N/A |
| Completed | Randomized Trial of Early Versus Standard Drainage Removal After Pancreatic Resections NCT00931554 | Universita di Verona | N/A |
| Completed | Closed Suction Drainage and Natural Drainage of the Pancreatic Duct in Pancreaticojejunostomy NCT00679952 | Seoul National University Hospital | Phase 3 |
| Completed | Enteral Nutrition in the Treatment of Pancreatic Fistulas - A Prospective Study NCT01025414 | Jagiellonian University | Phase 4 |
| Completed | External Pancreatic Duct Stent After Pancreaticoduodenectomy NCT01068886 | University Hospital, Angers | Phase 3 |
| Completed | Preoperative Inflammatory Biomarkers and Postoperative Day 1 Drain Amylase Value Predict Pancreatic Fistula Af NCT04361682 | Campus Bio-Medico University | — |
| Unknown | Anastomotic Techniques in Pancreaticoduodenectomy NCT00855985 | Lakeshore Hospital | N/A |