| Not Yet Recruiting | Permanent Supportive Housing Overdose Prevention-2 Study NCT07214519 | NYU Langone Health | N/A |
| Not Yet Recruiting | The Community Paramedic Response and Overdose Outreach With Supportive Medical-Legal Services Study NCT07216963 | Duke University | N/A |
| Not Yet Recruiting | Overdose Prevention Centers and Behavioral Health NCT06236087 | NYU Langone Health | — |
| Recruiting | A Universal Primary Care Based Intervention to Reduce Youth Overdose Risk NCT07022717 | Boston Medical Center | N/A |
| Recruiting | Shelter HArm Reduction Evaluation NCT07170072 | NYU Langone Health | — |
| Active Not Recruiting | Motivational Interviewing to Increase Uptake of Drug Checking and Safe Drug Use Behaviors to Reduce Overdose NCT06855836 | University of California, San Diego | N/A |
| Recruiting | Emergency Medicine Peer Outreach Worker Engagement for Recovery NCT06320015 | University of California, Los Angeles | — |
| Completed | Home Safety Intervention NCT06216327 | VA Office of Research and Development | N/A |
| Active Not Recruiting | The Ganchero Intervention for Migrant People Who Inject Drugs From Puerto Rico in New York City NCT06316739 | North Jersey AIDS Alliance dba North Jersey Community Research Initiative (NJCRI) | N/A |
| Enrolling By Invitation | Permanent Supportive Housing Overdose Prevention NCT05786222 | NYU Langone Health | N/A |
| Active Not Recruiting | Improving Access to Naloxone to Prevent Opioid Overdose Deaths (SAIA-Naloxone) NCT05886712 | RTI International | N/A |
| Completed | Pharmacist-Led Interventions to Increase Access to Medications for Opioid Use Disorders (PLI-MOUD) NCT05776823 | University of Arkansas | N/A |
| Unknown | Effects on Mortality and Clinical Course of a Patient's Choice Model for Opioid Maintenance Treatment for Opio NCT05678036 | Region Skane | — |
| Completed | Does a Soft Drink Mixture Improve Tolerance of Activated Charcoal in the Adult Poisoned Patient Without Affect NCT06219967 | State University of New York - Upstate Medical University | Phase 4 |
| Completed | Smartphone Intervention for Overdose and COVID-19 NCT05518461 | University of Wisconsin, Madison | N/A |
| Recruiting | Community-based Education, Navigation, and Support Intervention for Military Veterans NCT05343169 | New York University | N/A |
| Active Not Recruiting | Evaluation of a Medication Health Center to Promote Opioid Safety NCT06456294 | Kaiser Permanente | N/A |
| Completed | Emergency Room Firearm and Medication Safety Intervention NCT04797221 | VA Office of Research and Development | — |
| Completed | Mental Health Associations With Vitiligo NCT04953338 | Momentum Data | — |
| Completed | Rapid Initiation of Drug Treatment Engagement NCT03908437 | University of Pennsylvania | Phase 4 |
| Completed | An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses NCT04212364 | Johns Hopkins Bloomberg School of Public Health | N/A |
| Completed | SOONER Feasibility Study Protocol NCT03821649 | Unity Health Toronto | N/A |
| Completed | Consequences of Doing What Should Not be Done in Primary Care NCT03482232 | Universidad Miguel Hernandez de Elche | — |
| Completed | Naloxone Nasal Spray Compared With Naloxone Injection for Opioid Overdoses Outside the Hospital NCT03518021 | Norwegian University of Science and Technology | Phase 3 |
| Completed | Project POINT: Effectiveness and Scalability of an Overdose Survivor Intervention NCT03336268 | Indiana University | N/A |
| Active Not Recruiting | The Impact of a Web-Based Naloxone Intervention Under Standing Orders to Patients Prescribed Chronic Opioid Th NCT03337009 | Kaiser Permanente | N/A |
| Completed | The Impact of Co-Dispensing Naloxone to Patients Prescribed Chronic Opioid Therapy NCT03337100 | Kaiser Permanente | N/A |
| Completed | AWAITS: A Web-based E-health Application for Active Illicit Opioid Users NCT03402672 | University of Cincinnati | N/A |
| Completed | Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders NCT03241771 | Kaiser Permanente | N/A |
| Completed | Phone Interview to Prevent Recurring Opioid Overdoses NCT02282306 | University of Cincinnati | N/A |
| Completed | Prospective Cohort Study of Intravenous Lipid Emulsion for Resuscitating Critically-ill Poisoned Patients NCT03107689 | University of Southern California | — |
| Completed | Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP) NCT01050270 | University of Edinburgh | Phase 4 |
| Completed | Monitoring of Overdose Patients With and Without Supplemental Oxygen in the Emergency Department NCT02101424 | Hennepin Healthcare Research Institute | — |