| Recruiting | Alendronate for Osteonecrosis in Adults With Sickle Cell Disease NCT06016634 | University of California, Davis | Phase 2 |
| Not Yet Recruiting | Outcomes From Hyperbaric Oxygen (HBO2) Treatment for Emerging Indications NCT07240649 | Jay C. Buckey Jr. | Phase 4 |
| Not Yet Recruiting | Effect of HBOT on Femoral Head Avascular Necrosis (AVN) NCT06931301 | Yale University | N/A |
| Recruiting | Early Feasibility Study of Cartilage Defect Repair NCT06823089 | Cytex Therapeutics, Inc. | N/A |
| Active Not Recruiting | A Phase II Trial of RAB001 (LLP2A-Alendronate) for Steroid-Induced Early-Stage Osteonecrosis of the Femoral He NCT07471880 | ZhongShan LaiBo RuiChen BioMedicine Co.,Ltd. | Phase 2 |
| Terminated | In-vivo Wear Behaviour of AS Coated Versus Uncoated Columbus® Total Knee Prosthesis NCT05509972 | Aesculap AG | — |
| Recruiting | PROMIS Evaluation Study NCT05734651 | Bezirkskrankenhaus St. Johann in Tirol | — |
| Active Not Recruiting | The Use of Genex in the Management of Early-Stage Osteonecrosis of the Femoral Head NCT05706909 | The Cleveland Clinic | — |
| Active Not Recruiting | Sickle Cell Disease (SCD) Bone Pain Study NCT05283148 | University of California, Davis | N/A |
| Active Not Recruiting | TESS V3 Modular Total Shoulder System PMCF NCT05002959 | Zimmer Biomet | — |
| Completed | Post-COVID-19 Sequelae: Osteonecrosis of Femoral Head NCT05684588 | FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS | N/A |
| Completed | Hypertension Intervention to Reduce Osteonecrosis in Children With Acute Lymphoblastic Leukemia/Lymphoma NCT04401267 | St. Jude Children's Research Hospital | Phase 2 |
| Terminated | MOTO Post-marketing Surveillance Study NCT04072055 | Medacta International SA | — |
| Terminated | Use of Adipose Derived Regenerative Cells in Bilateral Femoral Head Osteonecrosis NCT03269409 | Mayo Clinic | Phase 1 |
| Unknown | The British Osteonecrosis Study NCT02598401 | University of Leeds | — |
| Completed | Meditation and Opioid Consumption in Total Joint Replacement Patients Undergo Primary Total Hip and Knee Repla NCT05669066 | Beth Israel Deaconess Medical Center | N/A |
| Completed | Safety and Tolerability of Intravenous LLP2A-Alendronate for Osteopenia Secondary to Glucocorticoids NCT03197623 | Nancy E. Lane, MD | Phase 1 |
| Withdrawn | Intravenous Zoledronic Acid for the Treatment of Osteoporosis and Osteonecrosis in Children With Leukemia: A P NCT02632903 | Children's Hospital of Eastern Ontario | Phase 2 |
| Terminated | Human Mesenchymal Stem Cells in the Synovial Fluid of the Hip NCT02941666 | Mayo Clinic | — |
| Unknown | Musculoskeletal Non-tumoral Pathology Quantitative Perfusion NCT02683252 | Central Hospital, Nancy, France | N/A |
| Completed | Functional Outcomes Following Hip Core Decompression in Younger Participants With Osteonecrosis NCT02458937 | St. Jude Children's Research Hospital | — |
| Completed | Imaging of Osteonecrosis With Ferumoxytol-Enhanced MRI NCT02893293 | Stanford University | Phase 4 |
| Unknown | Osteoporosis and Knee Insufficiency Fracture NCT02332681 | University of Sao Paulo General Hospital | — |
| Completed | A Novel Reconstruction Device for Osteonecrotic Femoral Head Efficacy Evaluation NCT04103944 | National Taiwan University Hospital | N/A |
| Completed | Focused Registry on the Conservative Treatment of Osteoarthritis of the Knee NCT02077647 | AO Clinical Investigation and Publishing Documentation | — |
| Recruiting | Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction NCT02661139 | AZ Sint-Jan AV | — |
| Completed | Randomized Clinical Trial for the Treatment of Osteonecrosis of the Femoral Head NCT01892514 | Istituto Ortopedico Rizzoli | Phase 3 |
| Terminated | Oxford Signature vs. Conventional Global Study NCT01763684 | Zimmer Biomet | N/A |
| Unknown | Osteonecroses in Pediatric Patients With ALL NCT01619124 | Klinik für Kinder-Onkologie, -Hämatologie und Klinische Immu | — |
| Unknown | Mononuclear Cells, Platelets and Zoledronic Acid for Preventing Collapse of the Femoral Head in Osteonecrosis NCT02721940 | Chinese PLA General Hospital | N/A |
| Withdrawn | Gender Solutions Natural Knee Post-Market Study NCT01463566 | Zimmer Biomet | — |
| Active Not Recruiting | ACI-C Versus AMIC. A Randomized Trial Comparing Two Methods for Repair of Cartilage Defects in the Knee NCT01458782 | University Hospital of North Norway | N/A |
| Completed | Effect of Cycle Ergometer in the Rehabilitation of Elderly Patients With Total Hip Arthroplasty NCT01622465 | University of Campinas, Brazil | Phase 2 |
| Terminated | Post Market Clinical Follow-Up of the Zimmer Stafit Acetabular System NCT04079114 | Zimmer Biomet | — |
| Completed | Genetic Risk of Osteonecrosis of the Jaw (ONJ) in Patients With Metastatic Cancer NCT01325142 | University of Michigan | — |
| Unknown | Transplantation of Bone Marrow Stem Cells Stimulated by Proteins Scaffold to Heal Defects Articular Cartilage NCT01159899 | Michel Assor, MD | EARLY_Phase 1 |
| Completed | Avenir Müller Hip Stem Post Market Surveillance Study NCT04079127 | Zimmer Biomet | — |
| Completed | Efficacy of Aquamantys for Reducing Transfusions With Anterior Supine Intermuscular Approach Total Hip Arthrop NCT01583465 | Joint Implant Surgeons, Inc. | N/A |
| Unknown | Osteonecrosis of the Hip and Bisphosphonate Treatment NCT00781261 | University of Sydney | Phase 2 |
| Completed | Evaluate the Effect of Bone Marrow Derived Cd133+ Cells in Patient With Osteonecrosis of Femoral Head NCT01198080 | Royan Institute | Phase 1 |
| Completed | Treatment of Medial Compartmental Osteoarthritis Grade 1-4 With TomoFix™ Small or Conservatively NCT01048710 | Synthes GmbH | — |
| Unknown | Osteonecrosis in Children With Acute Lymphoblastic Leukemia NCT01104324 | Halton, Jacqueline, M.D. | — |
| Completed | A Comparison of Two Different Surgical Techniques in Hip Resurfacing Arthroplasty NCT00913679 | University of Aarhus | N/A |
| Withdrawn | Zoledronic Acid Treatment of Spontaneous Osteonecrosis of the Knee NCT00477217 | Novartis | Phase 2 |
| Completed | Proposal For The Development Of A Well Defined Database For Patients With Oral Bisphosphonate-Related Osteonec NCT00601068 | University of Florida | — |
| Completed | Ixmyelocel-T Treatment of Patients With Osteonecrosis of the Femoral Head NCT00505219 | Vericel Corporation | Phase 3 |
| Recruiting | Exactech Shoulder Post Market Clinical Follow-up Study NCT05603728 | Exactech | — |
| Completed | Randomized Controlled Trial of Hyperbaric Oxygen in Patients Who Have Taken Bisphosphonates NCT00462098 | Duke University | Phase 1 |
| Unknown | MBCP Safety and Performance in the Osteonecrosis of Femur Head NCT00289575 | Biomatlante | Phase 2 |
| Completed | A Short Metaphyseal Fitting Total Hip Arthroplasty in Young and Elderly Patients NCT01345097 | Ewha Womans University | Phase 4 |
| Unknown | Molecular Genetic Study of Avascular Necrosis of the Femoral Head NCT00260897 | National Health Research Institutes, Taiwan | — |
| Completed | Vertebral Fracture and Osteonecrosis Associated With High-dose Glucocorticoid NCT00679978 | Saitama Medical University | — |
| Completed | Comparison of Ceramic-on-Ceramic and Ceramic-on-Highly-Cross-Linked Polyethylene Bearings NCT01806766 | Ewha Womans University | Phase 4 |
| Completed | Core Decompression With or Without Cement Packing for ONFH NCT04233125 | University of Minnesota | Phase 1 / Phase 2 |