NF1

17 registered clinical trials studyying NF1 — 6 currently recruiting.

Status	Trial	Sponsor	Phase
Not Yet Recruiting	Trial of Selumetinib and Bromodomain Inhibitor With Durvalumab for Sarcomas NCT05253131	University of Alabama at Birmingham	Phase 2
Recruiting	Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1 NCT07102394	Johns Hopkins University	Phase 1
Not Yet Recruiting	Follow-up Study to Evaluate the Safety and Efficacy of FCN-159 in Pediatric Participants With Neurofibromatosi NCT07024394	Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.	Phase 1 / Phase 2
Recruiting	Mirdametinib Monotherapy in Adults With Neurofibromatosis 1 (NF1) and Cutaneous Neurofibromas (cNF). NCT06159166	Johns Hopkins University	Phase 1 / Phase 2
Recruiting	A Study of Avutometinib for People With Solid Tumor Cancers NCT06104488	Memorial Sloan Kettering Cancer Center	Phase 1
Active Not Recruiting	FCN-159 in Adult Patients With Symptomatic, Inoperable Neurofibromatosis Type 1-Related Plexiform Neurofibroma NCT05913037	Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.	Phase 3
Enrolling By Invitation	Developing Biomarkers of Plexiform Tumor Burden in Patients With Neurofibromatosis-Type 1 NCT05238909	Ann & Robert H Lurie Children's Hospital of Chicago	—
Terminated	A Phase II Trial of Poly-ICLC for Low-Grade Gliomas NCT04544007	University of Alabama at Birmingham	Phase 2
Active Not Recruiting	Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and NCT04954001	Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd.	Phase 1 / Phase 2
Active Not Recruiting	Interventions for Reading Disabilities in NF1 NCT02964884	Vanderbilt University	Phase 2
Terminated	A Study of INFUSE Bone Graft (BMP-2) in the Treatment of Tibial Pseudarthrosis in Neurofibromatosis Type 1 (NF NCT02718131	University of Alabama at Birmingham	N/A
Completed	Cabozantinib for Plexiform Neurofibromas (PN) in Subjects With NF1 in Children and Adults NCT02101736	University of Alabama at Birmingham	Phase 2
Terminated	Study of Sutent®/Sunitinib (SU11248) in Subjects With NF-1 Plexiform Neurofibromas NCT01402817	Indiana University	Phase 2
Active Not Recruiting	AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors NCT01362803	National Cancer Institute (NCI)	Phase 1 / Phase 2
Completed	Study of Tasigna®/Nilotinib (AMN107) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas NCT01275586	Indiana University	EARLY_Phase 1
Completed	Adaptation and Quality of Life Among Adults With Neurofibromatosis Type I NCT00684398	National Human Genome Research Institute (NHGRI)	—
Completed	Study of Plexiform Neurofibromas in Neurofibromatosis Type 1 NCT00006435	National Cancer Institute (NCI)	—