| Recruiting | Surgical Procedure Efficiency Evaluation stuDy NCT07228091 | Alcon Research | — |
| Not Yet Recruiting | Comparison of Efficacy Between ILM Forceps NCT06536569 | University of British Columbia | Phase 4 |
| Enrolling By Invitation | Intraocular Gas Tamponade for Treatment of Large Idiopathic Macular Holes NCT06927544 | The Filatov Institute of Eye Diseases and Tissue Therapy | N/A |
| Enrolling By Invitation | Comparative Study of Decellularized Human Amniotic Membrane Hydrogel and Inverted Internal Limiting Membrane F NCT06433284 | Walailak University | N/A |
| Recruiting | Small Macular Holes Treated With Air NCT06211907 | Helse Stavanger HF | N/A |
| Recruiting | PEELED INTERNAL LIMITING MEMBRANE REPOSITION NCT06359548 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | N/A |
| Not Yet Recruiting | GaslEss Macular Hole Surgery NCT06079593 | King's College Hospital NHS Trust | N/A |
| Recruiting | Duration of Face Down Positioning for Full-Thickness Macular Hole Repair NCT06000111 | St. Joseph's Healthcare Hamilton | N/A |
| Completed | Zeiss RESIGHT Disposable Lenses Evaluation Study NCT05860985 | Universitaire Ziekenhuizen KU Leuven | N/A |
| Unknown | Platelet-rich Fibrin(PRF) Membrane in Ophthalmic Diseases NCT06200727 | Lei Du | N/A |
| Completed | Autologous Platelet-rich Plasma as a Treatment for Macular Holes NCT06323902 | Clinica Oftalmologica Paredes | — |
| Completed | Efficacy and Safety Evaluation of MONOBLUE DUAL View and MONOBLUE ILM View Vital Stains NCT05517473 | Universitaire Ziekenhuizen KU Leuven | — |
| Unknown | Clinical Study of Translocated Internal Limiting Membrane Flap Reposition for the Treatment of Idiopathic Macu NCT06063005 | Xinhua Hospital, Shanghai Jiao Tong University School of Medicine | N/A |
| Unknown | To Evaluate the Therapeutic Efficacy of Hydrated Amniotic Membrane in Promoting Closure of Refractory Macular NCT05396209 | Oriental Neurosurgery Evidence-Based-Study Team | N/A |
| Unknown | Treatment of Challenging Macular Holes Using Plasma Rich in Growth Factors NCT06115005 | Minia University | Phase 2 |
| Completed | Double Flap Technique for Macular Hole NCT05269563 | Omer Othman Abdullah | N/A |
| Unknown | Macular Micro Vascular Changes Following Macular Hole Repair : Optical Coherence Tomography Angiography Study NCT06233500 | Fayoum University | N/A |
| Completed | Postoperative Same Day Closure of Giant Macular Hole With Silicone Oil NCT06915948 | Ahalia Foundation Eye Hospital | — |
| Unknown | Pars Plana Vitrectomy With 25-gauge 20000 Cpm, Bevel-tip Cutter NCT04404296 | Peregrine Eye and Laser Institute | N/A |
| Unknown | Large Macular Hole Closure Rate With Amniotic Membrane Graft With and Without Limitorrhexis NCT05083650 | Instituto de Oftalmología Fundación Conde de Valenciana | N/A |
| Unknown | Multimodal Imaging in Vitreo-retinal Surgery and Macular Dystrophies NCT05747144 | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | — |
| Unknown | ILM Peeling Versus Inverted Flap Technique for Treatment of Macular Hole: Near Visual Acuity Outcomes NCT04698226 | Faculty Hospital Kralovske Vinohrady | N/A |
| Completed | Retrospective Evaluation of Risk Factors for Lower Outcomes After Vitrectomy With ILM Flap Technique NCT04883697 | Vienna Institute for Research in Ocular Surgery | — |
| Completed | Position Related Changes in Macular Hole Morphology Before and After Surgery NCT04676217 | Helse Stavanger HF | N/A |
| Completed | Efficacy of Exercise Program for Facedown Posture-related Pain After Retinal Surgery NCT04535622 | Samsung Medical Center | N/A |
| Completed | Computer Aided Diagnosis of Multiple Eye Fundus Diseases From Color Fundus Photograph NCT04723160 | Visionary Intelligence Ltd. | — |
| Completed | Optical Coherence Tomography Angiography Characteristics of Patients With Surgically Closed Full-thickness Idi NCT05223205 | Medical University of Graz | N/A |
| Unknown | Comparative Study of Sharkskin Versus Grieshaber Forceps During ILM Peeling NCT04459949 | Wills Eye | N/A |
| Active Not Recruiting | The Use of Amniotic Membrane or Internal Limiting Membrane for Large or Refractory Macular Holes: A Prospectiv NCT04904679 | Hospital Oftalmologico de Sorocaba | N/A |
| Terminated | Amniotic Membrane Visio-AMTRIX in Recurrent Macular Hole NCT05191628 | TBF Genie Tissulaire | Phase 2 |
| Unknown | Oral Sedation in Vitreoretinal Surgery NCT04346095 | Rocky Vista University, LLC | Phase 4 |
| Unknown | The Correlation of Preoperative Measurement Parameter on the Predicting of Visual Outcomes Among Patients With NCT04957459 | Second Affiliated Hospital, School of Medicine, Zhejiang University | — |
| Unknown | Inverted ILM-flap Techniques Variants for Macular Hole Surgery: Outcomes Comparison NCT04135638 | University of Molise | N/A |
| Completed | Measuring Subjective Quality of Vision and Metamorphopsia Before and After Epiretinal Membrane and Macular Hol NCT05171621 | Hayley Westwood | — |
| Completed | Human Amniotic Membrane Plug for Large Macular Holes NCT03917602 | University of Alexandria | N/A |
| Unknown | Comparative Analysis of Large Macular Hole Surgeries NCT04116892 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Unknown | Clinical Research on the Effect of Different Extents of Internal Limiting Membrane Peeling on Macular Hole Clo NCT03805763 | Wenzhou Medical University | N/A |
| Completed | Surgical Outcome of Macular Membrane Peeling Associated With Significant Macular Drusen NCT03927430 | Klinikum Chemnitz gGmbH | — |
| Recruiting | Intraoperative OCT Guidance of Intraocular Surgery II NCT03713268 | Duke University | — |
| Completed | Air Tamponade and Non-supine Positioning in Macular Hole Surgery. NCT03572725 | Helse Stavanger HF | N/A |
| Completed | ILM Flap Transposition Versus ILM Peeling for Macular Holes: a Pilot Study NCT03646695 | Vienna Institute for Research in Ocular Surgery | N/A |
| Unknown | Compare the Healing Process of Idiopathic Macular Hole With Different Surgical Techniques NCT03888625 | Federal University of São Paulo | N/A |
| Completed | Safety and Efficacy Evaluation of Two Different Brilliant Blue G Dyes as Staining Agent in Vitreo Retinal Surg NCT05086588 | Dr. Lutfi Kirdar Kartal Training and Research Hospital | — |
| Completed | Effects of Macular Buckle Versus Vitrectomy on Macular Hole and Macular Detachment in Highly Myopic Eyes NCT03433547 | Sun Yat-sen University | N/A |
| Completed | Infracyanine Green vs Brilliant Blue G in Macular Hole Inverted Flap Surgery: A Swept Source OCT Analysis. NCT03946267 | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | N/A |
| Completed | Comparison of Vitrectomy Without Internal Limiting Membrane Peeling Versus Inverted ILM Flap Technique for Mac NCT04011007 | University of Alexandria | N/A |
| Completed | Macular Hole After Diabetic Vitrectomy NCT03525899 | National Taiwan University Hospital | — |
| Unknown | A Study of a New Surgical Treatment of Macular Hole Retinal Detachment in High Myopia NCT03383731 | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | N/A |
| Unknown | MSC-Exos Promote Healing of MHs NCT03437759 | Tianjin Medical University | EARLY_Phase 1 |
| Completed | Clinical Characteristics and Surgical Outcomes of Full-thickness Macular Hole Without Focal Vitreomacular Trac NCT06560710 | St. Marianna University School of Medicine | — |
| Completed | Comparison of Two Intraocular Gas Injection Techniques in Macula Hole Surgery NCT04527848 | Universidade Federal de Pernambuco | Phase 4 |
| Completed | High Myopia Macular Hole and Retinal Detachment Treated With Double ILM Flaps NCT03174639 | National Taiwan University Hospital | N/A |
| Completed | The Application of M-charts and Microperimetry for the Assessment of Visual Function in Patients After Vitrect NCT03701542 | Medical University of Lublin | — |
| Completed | Preoperative Progression of Macular Holes NCT02203929 | Glostrup University Hospital, Copenhagen | — |
| Completed | Air Tamponade in Macular Holes < 400 μm NCT02028481 | Helse Stavanger HF | N/A |
| Completed | Postoperative Positioning After Surgery for Macular Holes NCT01974310 | Glostrup University Hospital, Copenhagen | N/A |
| Completed | Extent of ILM Removal and Its Impact on Outcomes of MH Surgery NCT02010138 | Samsung Medical Center | N/A |
| Unknown | Macular Hole Surgery With and Without Internal Limiting Membrane Peeling：A Systematic Review and Meta-analysis NCT01687829 | Yifan Feng | — |
| Unknown | Inverted ILM Repositioning as Treatment for Full Thickness Macular Holes NCT01228188 | Military Institute od Medicine National Research Institute | N/A |
| Completed | Evaluation of Anatomic and Visual Outcomes of Initially Closed Macular Holes NCT01229657 | Sun Yat-sen University | — |
| Completed | Impact of C3F8 or SF6 Use and Length of Face-down Positioning (7 vs 14 Days Respectively) in Macular Hole Surg NCT02073266 | CHU de Quebec-Universite Laval | N/A |
| Completed | Elongation of Foveal Tissue After Macular Hole Surgery NCT01471912 | Samsung Medical Center | N/A |
| Completed | Observation of Recovery of Foveal Cone Microstructures After Macular Hole Surgery NCT01306487 | Kyorin University | — |
| Completed | Foveal Cone Outer Segment Resumption to Predict Visual Recovery After Macular Hole Surgery NCT01381965 | Kyorin University | N/A |
| Completed | Blue-Blocking IOLs in Combined Surgery NCT00537992 | The Ludwig Boltzmann Institute of Retinology and Biomicroscopic Laser Surgery | N/A |