| Not Yet Recruiting | Lumbar Punctures for the Detection of ctDNA in the Cerebrospinal Fluid of Patients With Stage III and IV Non-S NCT06816979 | Ohio State University Comprehensive Cancer Center | N/A |
| Not Yet Recruiting | Testing the Impact of an Anti-Cancer Drug, Atezolizumab, After Surgery to Prevent Early Stage Non-small Cell L NCT07388524 | National Cancer Institute (NCI) | Phase 3 |
| Not Yet Recruiting | Photoimmunotherapy With ASP-1929 and Cemiplimab for the Treatment of Refractory, Inoperable, and Metastatic St NCT06943664 | Roswell Park Cancer Institute | Phase 2 |
| Recruiting | Psilocybin-Assisted Therapy for the Treatment of Major Depressive Disorder in Patients With Non-Small Cell Lun NCT07216404 | Alan Davis | Phase 2 |
| Recruiting | Immunotherapy Biomarkers to Predict First-line PD(L)1-based Immunotherapy Response and Selection of Second-lin NCT07288034 | City of Hope Medical Center | Phase 2 |
| Not Yet Recruiting | A Study of Targeted Post-Surgery Radiation Therapy for Non-Small Cell Lung Cancer With Remaining Lymph Node Ca NCT07293247 | Alliance for Clinical Trials in Oncology | Phase 2 |
| Recruiting | Experiences w/ & Attitudes Towards Immune Chckpt Inhibitors in NSCLC Patients Single Center Survey Based Study NCT07339254 | University of Southern California | — |
| Recruiting | Telisotuzumab Vedotin and Osimertinib for the Treatment of Progressive, Incurable, Non Small Cell Lung Cancer NCT07323641 | Jonsson Comprehensive Cancer Center | Phase 2 |
| Recruiting | Exercise Training for the Improvement of Immune Activity and Treatment Outcomes During Immunotherapy for Non-s NCT06983899 | Fred Hutchinson Cancer Center | N/A |
| Recruiting | Qualitative Study on Detection & Tx of NSCLC in Pts w/ a History of Alcohol or SUD NCT07186699 | University of Southern California | — |
| Active Not Recruiting | Testing the Addition of AZD6738 (Ceralasertib) to Immunotherapy to Increase Time Without Cancer for Patients W NCT06732401 | National Cancer Institute (NCI) | Phase 3 |
| Recruiting | Cemiplimab and Fianlimab Before Surgery for the Treatment of Stage IB-IIIB Non-Small Cell Lung Cancer NCT06918132 | Mayo Clinic | Phase 2 |
| Recruiting | Immunotherapy After Surgery for People Who Have No Remaining Cancer Cells After Standard Treatment for Early-S NCT06498635 | National Cancer Institute (NCI) | Phase 3 |
| Recruiting | Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology C NCT06418204 | Wake Forest University Health Sciences | — |
| Recruiting | Targeted Treatment for Advanced Non-Small Cell Lung Cancer That Has Increased Copies of the MET Gene (An Expan NCT06116682 | SWOG Cancer Research Network | Phase 2 |
| Recruiting | Grid Radiation Therapy for the Treatment of Stage IV Non-Small Cell Lung Cancer NCT06660407 | Mayo Clinic | Phase 2 |
| Recruiting | Biologically Guided Radiation Therapy (BgRT) and Stereotactic Body Radiation Therapy (SBRT) to Tyrosine Kinase NCT06014827 | City of Hope Medical Center | Phase 2 |
| Withdrawn | An Investigational Scan (124I-hJAA-F11 PET/CT) for Diagnosing Lung Cancer NCT06427369 | Roswell Park Cancer Institute | Phase 1 |
| Not Yet Recruiting | From Benchmark to Surgical Activity: the Role of Endobronchial Fiducial Markers for Ground Glass Lung Nodules NCT05801406 | IRCCS Azienda Ospedaliero-Universitaria di Bologna | — |
| Recruiting | Gilteritinib for the Treatment of ALK NSCLC NCT06225427 | University of Michigan Rogel Cancer Center | Phase 1 |
| Recruiting | Evaluation of Geriatric Assessment and Management for Older Adults With Non-small Cell Lung Cancer Receiving C NCT06139627 | City of Hope Medical Center | N/A |
| Recruiting | Comparison of In-Home Versus In-Clinic Administration of Subcutaneous Nivolumab Through Cancer CARE (Connected NCT06265285 | Mayo Clinic | Phase 2 |
| Terminated | Durvalumab and Grid Therapy for Non-small Cell Lung Cancer in Progression During or After Treatment With PACIF NCT05443971 | Mayo Clinic | Phase 1 |
| Withdrawn | Pilot Trial of E Cigarettes in Pts Diagnosed With Cancer of the Head, Neck, and Lung NCT05412875 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | Quality of Life Intervention to Inform Patient Decision-Making in Early-Stage Lung Cancer NCT05292521 | Roswell Park Cancer Institute | N/A |
| Recruiting | Positron Emission Tomography (PET) Guided Stereotactic Body Radiation Therapy for the Treatment of Oligoprogre NCT05830058 | City of Hope Medical Center | Phase 2 |
| Recruiting | A Tool for Improving the Shared Decision-making Process in Patients With Non-small Cell Lung Cancer NCT06122064 | Mayo Clinic | N/A |
| Recruiting | Stereotactic Body Radiation Therapy Planning With Artificial Intelligence-Directed Dose Recommendation for Tre NCT05802186 | Northwestern University | N/A |
| Recruiting | Phase II Trial of Lung Chemoemobolization NCT05672108 | City of Hope Medical Center | Phase 2 |
| Recruiting | Split Course Adaptive Radiation Therapy With Pembrolizumab With/Without Chemotherapy for Treating Stage IV Lun NCT05501665 | Vanderbilt-Ingram Cancer Center | Phase 1 / Phase 2 |
| Active Not Recruiting | A Multiple Antigen Vaccine (STEMVAC) for the Treatment of Patients With Stage IV Non-Small Cell Lung Cancer NCT05242965 | University of Washington | Phase 2 |
| Active Not Recruiting | Subcutaneous Atezolizumab for the Treatment of Non-small Cell Lung Cancer NCT05340309 | University of Southern California | Phase 2 |
| Recruiting | Low-Dose Interleukin-2 and Pembrolizumab for the Treatment of Stage IV Non-Small Cell Lung Cancer NCT05493566 | Emory University | EARLY_Phase 1 |
| Suspended | Testing the Addition of Radiation Therapy to the Usual Treatment (Immunotherapy With or Without Chemotherapy) NCT04929041 | National Cancer Institute (NCI) | Phase 2 / Phase 3 |
| Recruiting | The Impact of Surgical Technique on Circulating Tumor DNA in Stage I-III Non-Small Cell Lung Cancer NCT05502523 | Thomas Jefferson University | N/A |
| Withdrawn | Testing the Use of Targeted Treatment for RET Positive Advanced Non-small Cell Lung Cancer NCT05364645 | SWOG Cancer Research Network | Phase 2 |
| Terminated | Photodynamic Therapy to Amplify the Response to Immunotherapy in Patients With Non-small Cell Lung Cancer With NCT04836429 | Roswell Park Cancer Institute | Phase 1 |
| Completed | Developing a Shared Decision Making Tool for Patients With Surgically Removed Non-small Cell Lung Cancer NCT05416983 | Mayo Clinic | — |
| Withdrawn | Robotic Bronchoscopy With Cone CT and Indocyanine Green to Aid Removal of Lung Lesions in Patients With Stage NCT04987281 | M.D. Anderson Cancer Center | Phase 2 |
| Completed | A Vaccine (CIMAvax-EGF) for the Prevention of Lung Cancer Development or Recurrence NCT04298606 | Roswell Park Cancer Institute | EARLY_Phase 1 |
| Withdrawn | Testing the Addition of an Immunotherapy Drug, Atezolizumab, to the Usual Chemotherapy Treatment During Radiat NCT04989283 | National Cancer Institute (NCI) | Phase 2 |
| Withdrawn | Physical Activity Intervention Before and After Surgery in Older Adults With Lung Cancer and Their Family Care NCT04085081 | City of Hope Medical Center | N/A |
| Active Not Recruiting | Testing the Use of Targeted Treatment (AMG 510) for KRAS G12C Mutated Advanced Non-squamous Non-small Cell Lun NCT04625647 | SWOG Cancer Research Network | Phase 2 |
| Terminated | Cognitive-Behavioral Stress Management Device for the Treatment of Anxiety and Depressive Symptoms in Patients NCT04705025 | Jonsson Comprehensive Cancer Center | N/A |
| Active Not Recruiting | Imaging and Blood-Based Biomarkers for the Evaluation of Early Signs of Myocardial Injury After Thoracic Radia NCT05717998 | Ohio State University Comprehensive Cancer Center | — |
| Recruiting | Role of Gut Microbiome and Fecal Transplant on Medication-Induced GI Complications in Patients With Cancer NCT03819296 | M.D. Anderson Cancer Center | Phase 1 |
| Withdrawn | Sapanisertib and Nivolumab for the Treatment of Stage I-IV Non-small Cell Lung Cancer in Patients Who Have Pro NCT05022394 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Terminated | Sirolimus and Durvalumab for the Treatment of Stage I-IIIA Non-small Cell Lung Cancer NCT04348292 | Emory University | Phase 1 |
| Recruiting | Predictive Biomarkers for Pneumonitis After Chemoradiotherapy and Immunotherapy in Patients With Non-small Cel NCT04913311 | M.D. Anderson Cancer Center | — |
| Active Not Recruiting | Study of Radiation Therapy Followed by Atezolizumab in Stage II or III Non-small Cell Lung Cancer Patients NCT04310020 | National Cancer Institute (NCI) | Phase 2 |
| Active Not Recruiting | National Cancer Institute "Cancer Moonshot Biobank" NCT04314401 | National Cancer Institute (NCI) | — |
| Completed | Effectiveness of an Enhanced Tobacco Intervention Protocol Compared to Standard Treatment in Helping Head and NCT04694846 | Thomas Jefferson University | N/A |
| Active Not Recruiting | Testing the Addition of the Drug Atezolizumab to the Usual Radiation Treatment for Patients With Early Non-sma NCT04214262 | National Cancer Institute (NCI) | Phase 3 |
| Active Not Recruiting | Pembrolizumab Every 12 Weeks Versus Every 3 Weeks in Treating Patients With Non-small Cell Lung Cancer NCT04032418 | Roswell Park Cancer Institute | Phase 2 |
| Active Not Recruiting | Decision Aid for the Improvement of Decision-Making in Patients With Non-small Cell Lung Cancer NCT04946279 | OHSU Knight Cancer Institute | N/A |
| Active Not Recruiting | Self-Management Survivorship Care in Stage I-III Non-small Cell Lung Cancer or Colorectal Cancer NCT04428905 | City of Hope Medical Center | Phase 3 |
| Active Not Recruiting | Infliximab or Vedolizumab in Treating Immune Checkpoint Inhibitor-Related Colitis in Patients With Genitourina NCT04407247 | M.D. Anderson Cancer Center | Phase 1 / Phase 2 |
| Completed | Testing a Cognitive Behavioral Model for Reducing Dyspnea in Patients With Lung Cancer NCT05304793 | Ohio State University Comprehensive Cancer Center | N/A |
| Recruiting | Testing the Addition of a Type of Drug Called Immunotherapy to the Usual Chemotherapy Treatment for Non-small NCT04267848 | National Cancer Institute (NCI) | Phase 3 |
| Withdrawn | Pembrolizumab With or Without Chemotherapy Before Surgery in Treating Patients With Stage I-IIIA Non-Small Cel NCT04061590 | University of California, San Francisco | Phase 2 |
| Withdrawn | Platinum-Based Chemotherapy and Durvalumab for the Treatment of Stage IIIB or IV Non-small Cell Lung Cancer NCT04262869 | Emory University | Phase 2 |
| Terminated | Brigatinib and Binimetinib in Treating Patients With Stage IIIB-IV ALK or ROS1-Rearranged Non-small Cell Lung NCT04005144 | University of California, San Francisco | Phase 1 |
| Active Not Recruiting | Single Fraction Stereotactic Body Radiation Therapy After Surgery in Treating Patients With Non-small Cell Lun NCT04073745 | Roswell Park Cancer Institute | Phase 1 |
| Active Not Recruiting | Ipilimumab and Nivolumab in Combination With Radiation Therapy in Treating Patients With Stage 2-3 Non-small L NCT04013542 | M.D. Anderson Cancer Center | Phase 1 |
| Active Not Recruiting | Microwave Ablation or Wedge Resection for the Treatment of Lung, Sarcoma and Colorectal Lesions, ALLUME Study NCT04430725 | M.D. Anderson Cancer Center | — |
| Active Not Recruiting | CCL21-Gene Modified Dendritic Cell Vaccine and Pembrolizumab in Treating Patients With Stage IV Non-small Cell NCT03546361 | Jonsson Comprehensive Cancer Center | Phase 1 |
| Active Not Recruiting | Treatment Effects on Development of Chemotherapy-Induced Peripheral Neuropathy in Patients With Cancer NCT03939481 | SWOG Cancer Research Network | — |
| Completed | Genetics and Shared Decision Making in Improving Care for Patients With Stage IVA-C Non-small Cell Lung Cancer NCT03944265 | Thomas Jefferson University | N/A |
| Active Not Recruiting | Papaverine and Stereotactic Body Radiotherapy (SBRT) for Non Small Cell Lung Cancer (NSCLC) or Lung Metastases NCT03824327 | Ohio State University Comprehensive Cancer Center | Phase 1 |
| Recruiting | Dyadic Yoga Intervention in Improving Physical Performance and Quality of Life in Patients With Stage I-IV Non NCT03948100 | M.D. Anderson Cancer Center | N/A |
| Active Not Recruiting | Local Consolidative Therapy and Brigatinib in Treating Patients With Stage IV or Recurrent Non-small Cell Lung NCT03707938 | M.D. Anderson Cancer Center | Phase 1 |
| Active Not Recruiting | Anamorelin Hydrochloride in Reducing Anorexia in Patients With Advanced Non-small Cell Lung Cancer NCT03637816 | M.D. Anderson Cancer Center | Phase 2 / Phase 3 |
| Completed | Pembrolizumab in Preventing Lung Cancer in Patients With Stage I-II Non-Small Cell Lung Cancer or High-Risk Pu NCT03634241 | M.D. Anderson Cancer Center | Phase 2 |
| Terminated | Bronchoscopic Laser Ablation of Peripheral Lung Tumors NCT03707925 | M.D. Anderson Cancer Center | N/A |
| Completed | Risk of Chemotherapy Toxicity in Older Patients With Blood Cancer or Non-small Cell Lung Cancer NCT05106374 | Ohio State University Comprehensive Cancer Center | — |
| Active Not Recruiting | Osimertinib, Surgery, and Radiation Therapy in Treating Patients With Stage IIIB or IV Non-small Cell Lung Can NCT03410043 | M.D. Anderson Cancer Center | Phase 2 |
| Active Not Recruiting | Nivolumab and Ipilimumab With or Without Local Consolidation Therapy in Treating Patients With Stage IV Non-Sm NCT03391869 | M.D. Anderson Cancer Center | Phase 3 |
| Completed | Pharmacokinetic Profiling of Pembrolizumab and Nivolumab in Patients With Melanoma and/or Non-Small Cell Lung NCT05740501 | Mayo Clinic | — |
| Active Not Recruiting | Danvatirsen and Durvalumab in Treating Patients With Advanced and Refractory Pancreatic, Non-Small Cell Lung C NCT02983578 | M.D. Anderson Cancer Center | Phase 2 |
| Active Not Recruiting | CIMAvax Vaccine, Nivolumab, and Pembrolizumab in Treating Patients With Advanced Non-small Cell Lung Cancer or NCT02955290 | Roswell Park Cancer Institute | Phase 1 / Phase 2 |