| Not Yet Recruiting | Endoscopic Ultrasound-Guided Loco-regional Chemotherapy Injection as Adjuvant Therapy for Locally Advanced Pan NCT07429643 | Assiut University | Phase 2 / Phase 3 |
| Not Yet Recruiting | Chemotherapy With or Without IMD10 (Focused Ultrasound) in the Treatment of Borderline Resectable or Locally A NCT07325214 | IMGT Co., Ltd. | N/A |
| Not Yet Recruiting | Alpha Radiation Emitters Device (DaRT) for the Treatment of Locally Advanced Pancreatic Cancer NCT06755359 | Alpha Tau Medical LTD. | N/A |
| Not Yet Recruiting | Stereotactic Centralized Ablative Radiotherapy for Locally Advanced Pancreatic Cancer: A Single-Arm Phase I Sa NCT07173374 | Shandong Cancer Hospital and Institute | Phase 1 |
| Recruiting | Systemic Therapy With a Loco-regional Treatment in Patients With Locally Advanced Pancreatic Cancer NCT04276857 | University of Saskatchewan | N/A |
| Recruiting | mFOLFIRINOX Plus Anlotinib and Sintilimab for Advanced Pancreatic Cancer NCT06761027 | Fujian Provincial Hospital | Phase 1 / Phase 2 |
| Recruiting | A New Clinical Pathway for Personalized Management of Borderline Resectable and Locally Advanced Pancreatic Ca NCT06944587 | Oslo University Hospital | — |
| Not Yet Recruiting | NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus NALIRIFOX as Conversion Therapy of Locally Advance NCT06669078 | The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Phase 2 |
| Active Not Recruiting | Nimotuzumab Plus NALIRIFOX in Locally Advanced Pancreatic Cancer NCT06429904 | Peking Union Medical College Hospital | Phase 2 |
| Completed | Irreversible Electroporation & Pembro Immunotherapy in Locally Advanced Pancreatic Cancer NCT06378047 | H. Lee Moffitt Cancer Center and Research Institute | Phase 1 |
| Recruiting | NALIRIFOX Combined With PD-1 Sequential Radiotherapy Versus AG Combined With PD-1 Sequential Radiotherapy as F NCT06494514 | Du Juan | N/A |
| Recruiting | MicroEnvironment Tumor Effects of Radiotherapy - Comprehensive Radiobiology Assessment TRial NCT05975593 | Washington University School of Medicine | N/A |
| Not Yet Recruiting | Surufatinib and Serplulimab Combined With AG Regimen Compare With AG Regimen as Conversion Therapy for Patient NCT05988372 | Sun Yat-sen University | Phase 2 |
| Not Yet Recruiting | SBRT Combined With Zimberelimab (GLS-010) in Locally Advanced Pancreatic Cancer (SPARK-1 Study) NCT06009029 | Peking University Third Hospital | Phase 2 |
| Active Not Recruiting | FOLFIRINOX Versus OncoSil™ in Addition to FOLFIRINOX in Patients With Locally Advanced Pancreatic Adenocarcino NCT05466799 | OncoSil Medical Limited | Phase 2 |
| Recruiting | Clinical Study of Tumor Treating Fields Combined with Gemcitabine and Albumin-bound Paclitaxel in the First-li NCT05653453 | Jiangsu Healthy Life Innovation Medical Technology Co., Ltd | Phase 3 |
| Unknown | Prophylactic Administration of Neulapeg (Pegteograstim) in Patients With Locally Advanced or Metastatic Pancre NCT06353581 | Yonsei University | Phase 2 |
| Recruiting | Combined Chemotherapy And Ablative Radiotherapy (SBRT) As First-Line Treatment In Locally Advanced Inoperable NCT07407231 | Institute of Oncology Ljubljana | N/A |
| Unknown | The Transformation of Locally Advanced Pancreatic Cancer. NCT04723030 | Peking University | Phase 2 |
| Completed | Good Choice of pALliative Chemotherapy to Patient With Pancreatic Cancer ; GemcitAbine Therapy vs FOLFORINOX t NCT04789980 | Boryung Pharmaceutical Co., Ltd | — |
| Unknown | Nab-paclitaxel and S-1 in Patients With Locally Advanced Pancreatic Cancer NCT03885219 | Peking Union Medical College Hospital | Phase 2 |
| Recruiting | Phase I Nab-Paclitaxel Plus Gemcitabine With Proton Therapy for Locally Advanced Pancreatic Cancer (LAPC) NCT03652428 | University of Maryland, Baltimore | Phase 1 / Phase 2 |
| Unknown | Nab-paclitaxel Combined With S-1 as Induction Therapy for Locally Advanced Pancreatic Cancer NCT03815461 | Chinese Academy of Medical Sciences | Phase 2 |
| Recruiting | Ceralasertib (AZD6738) Alone and in Combination With Olaparib or Durvalumab in Patients With Solid Tumors NCT03682289 | Rahul Aggarwal | Phase 2 |
| Completed | EndoTAG-1+GEM vs GEM in Patients With Locally Advanced/Metastatic Pancreatic Adenocarcinoma Failed on FOLFIRIN NCT03126435 | SynCore Biotechnology Co., Ltd. | Phase 3 |
| Completed | Stereotactic Radiotherapy (SBRT) in Patients With Locally Advanced Pancreatic Cancer (LAPC) NCT03648632 | Per Pfeiffer | N/A |
| Completed | 2nd-line Therapy With Nal-IRI After Gem/Nab-pac in Advanced Pancreatic Cancer - Predictive Role of 1st-line Th NCT03468335 | AIO-Studien-gGmbH | Phase 3 |
| Recruiting | Intra-arterial Gemcitabine vs. IV Gemcitabine and Nab-Paclitaxel Following Radiotherapy for LAPC NCT03257033 | RenovoRx | Phase 3 |
| Unknown | Divestment for Artery-involved Pancreatic Cancer NCT03443921 | The First Affiliated Hospital with Nanjing Medical University | N/A |
| Terminated | Folfirinox or Gemcitabine-Nab Paclitaxel Followed by Stereotactic Body Radiotherapy for Locally Advanced Pancr NCT03600623 | University of Alabama at Birmingham | EARLY_Phase 1 |
| Completed | FOLFOX-A For Locally Advanced Pancreatic Cancer: A Phase II Brown University Oncology Research Group Trial NCT02578732 | Brown University | Phase 2 |
| Terminated | Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With C NCT02404363 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Unknown | Safety and Efficacy of Irreversible Electroporation for Locally Advanced Pancreatic Cancer NCT02898649 | Yonsei University | N/A |
| Unknown | Pancreatic Locally Advanced Irresectable Cancer Ablation NCT03690323 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | N/A |
| Completed | Safety Study of Radiofrequency Ablation of Locally Advanced Pancreatic Cancer NCT01628458 | UMC Utrecht | Phase 2 |
| Completed | Phase II Study of Hypofractionated Radio-chemotherapy With Gemcitabine Plus Oxaliplatin for Unresectable Nonme NCT02035072 | Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS | Phase 2 |
| Completed | Metformin Combined With Chemotherapy for Pancreatic Cancer NCT01210911 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Phase 2 |
| Unknown | A Study of Locally Advanced Pancreatic Cancer NCT01063192 | National Health Research Institutes, Taiwan | Phase 2 |
| Unknown | Metastatic Advanced Pancreas Sorafenib NCT00758381 | Gruppo Italiano per lo studio dei Carcinomi dell'Apparato Digerente | Phase 2 |
| Completed | Gemcitabine, Oxaliplatin and Capecitabine for Advanced Pancreatic Carcinoma NCT00744640 | University Hospital, Basel, Switzerland | Phase 1 / Phase 2 |
| Completed | Randomized Controlled Trial of Gemcitabine Combined With 125I Brachytherapy NCT00644618 | Huazhong University of Science and Technology | Phase 3 |
| Withdrawn | Phase I Study Evaluating the Treatment of Patients With Locally Advanced Pancreatic Cancer With Carbon Ion Rad NCT01795274 | University Hospital Heidelberg | N/A |
| Available | Magnetic Resonance-guided High-intensity Focused Ultrasound Treatment of Locally Advanced Pancreatic Cancer NCT01786850 | University of Roma La Sapienza | — |