| Recruiting | Becotatug Vedotin (MRG003) in Combination With PD-1 Inhibitor Versus PD-1 Inhibitor for the Treatment of EGFR- NCT07524452 | Ming-Yuan Chen | Phase 3 |
| Recruiting | Comparison of Efficacy Between De-escalated Surgery and Standard Surgery After Neoadjuvant Immunotherapy in Lo NCT07369882 | Qunxing Li,MD | N/A |
| Recruiting | Low-Dose Radiotherapy and Anti-PD-1 Immunotherapy as Neoadjuvant Treatment for Resectable Locally Advanced Hea NCT07371234 | Xiwei XU | Phase 2 |
| Recruiting | Clinical Trial Comparing Induction Treatment With EGFR-ADC MRG003 Alone or in Combination With the Anti PD1 Pu NCT06959108 | Groupe Oncologie Radiotherapie Tete et Cou | Phase 2 |
| Not Yet Recruiting | [18F]-AraG PET Imaging in LA HNSCC NCT07168785 | Indiana University | EARLY_Phase 1 |
| Recruiting | Tirilizumab with Albumin-bound Paclitaxel and Cisplatin for Locally Advanced Resectable Oral Squamous Cell Car NCT06470217 | Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University | Phase 2 |
| Not Yet Recruiting | Toripalimab Maintenance for Locally Advanced Head and Neck Squamous Cell Carcinoma NCT05773079 | Nanfang Hospital, Southern Medical University | Phase 2 |
| Withdrawn | Study of RP3 in Combination With Nivolumab and Other Therapy in Patients With Locoregionally Advanced or Recur NCT05743270 | Replimune, Inc. | Phase 2 |
| Recruiting | A Prospective Randomized Controlled Study of Immune Checkpoint Maintenance Therapy After Radiotherapy and Chem NCT06240689 | Second Affiliated Hospital, School of Medicine, Zhejiang University | Phase 2 |
| Recruiting | A Global Study of Volrustomig (MEDI5752) for Participants With Unresected Locally Advanced Head and Neck Squam NCT06129864 | AstraZeneca | Phase 3 |
| Suspended | Radiotherapy Plus Xevinapant in Older Patients With Locally Advanced Head and Neck Squamous Cell Carcinoma NCT05724602 | European Organisation for Research and Treatment of Cancer - EORTC | Phase 2 |
| Recruiting | De-escalation Radiation Strategy After NAC in Combination With ICI in LAHNSCC NCT06572514 | Ruijin Hospital | Phase 1 / Phase 2 |
| Withdrawn | Home Sleep Apnea Machine in Evaluating Obstructive Sleep Apnea in Patients With Stage III-IV Head and Neck Can NCT03875053 | Barbara Ann Karmanos Cancer Institute | N/A |
| Unknown | Neoadjuvant Radiotherapy Combined With Toripalimab for Locally Advanced Head and Neck Squamous Cell Carcinoma NCT05861557 | Tianjin Medical University General Hospital | Phase 2 |
| Recruiting | Testing the Addition of Ipatasertib to Usual Chemotherapy and Radiation for Head and Neck Cancer NCT05172245 | National Cancer Institute (NCI) | Phase 1 |
| Enrolling By Invitation | Study of Cemiplimab - TP Induction Chemotherapy in Patients with Locally Advanced Squamous Cell Carcinoma of t NCT05376553 | Krzysztof Misiukiewicz | Phase 1 |
| Recruiting | TPExtreme Induced Chemotherapy Followed by Surgery and Radiotherapy in the Oral Carcinoma. NCT05872880 | Xiangya Hospital of Central South University | — |
| Recruiting | Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Soli NCT05269381 | Mayo Clinic | Phase 1 / Phase 2 |
| Active Not Recruiting | Tolinapant and Radiation for Cisplatin-Ineligible, Previously Untreated, Locally Advanced Head and Neck Cancer NCT05245682 | Emory University | EARLY_Phase 1 |
| Recruiting | JNJ-90301900 (NBTXR3) Activated by Radiotherapy With or Without Cetuximab in LA-HNSCC NCT04892173 | Johnson & Johnson Enterprise Innovation Inc. | Phase 3 |
| Completed | A Real-world Study of the Efficacy and Safety of Nimotuzumab in Combination With Chemoradiotherapy for LASCCHN NCT04949503 | Biotech Pharmaceutical Co., Ltd. | — |
| Completed | Group-Mediated Cognitive Behavioral Resistance Exercise Intervention in Head and Neck Cancer Patients Undergoi NCT04733495 | Ohio State University Comprehensive Cancer Center | N/A |
| Completed | Quad Shot Radiotherapy in Combination With Immune Checkpoint Inhibition NCT04454489 | Wake Forest University Health Sciences | Phase 2 |
| Unknown | Toripalimab Combined With Gemcitabine and Cisplatin Treating Resectable Locally Advanced HNSCC NCT04947241 | Fifth Affiliated Hospital, Sun Yat-Sen University | Phase 1 |
| Completed | Image-guided Proton Therapy for the Treatment of Locally Advanced Unresectable Head and Neck Cancer NCT04870840 | M.D. Anderson Cancer Center | Phase 1 |
| Completed | Sodium Thiosulfate in Preventing Ototoxicity for Squamous Cell Cancer Patients Undergoing Chemoradiation With NCT04541355 | Hyunseok Kang, MD | Phase 2 |
| Active Not Recruiting | Induction Modified TPF Followed by Concurrent Chemoradiotherapy in Locally Advanced Squamous Cell Carcinoma of NCT05527782 | Hospital Universitario Doctor Peset | Phase 2 |
| Recruiting | Low-Dose Weekly vs High-Dose Cisplatin NCT03649048 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Radiotherapy With Double Checkpoint Blockade of Locally Advanced HNSCC NCT03426657 | University of Erlangen-Nürnberg Medical School | Phase 2 |
| Unknown | the Study of Effect of Chronomodulated Chemotherapy on the Dendritic Cells Subsets in the Treatment of Advance NCT03196869 | Guiyang Medical University | Phase 2 |
| Unknown | Docetaxel and Loplatin Induction Chemotherapy Followed by Concurrent Chemoradiotherapy for Locally Advanced SC NCT03117257 | Guiyang Medical University | Phase 2 |
| Completed | Efficacy Study of Genexol-PM and Cisplatin in Locally Advanced Head and Neck Cancer NCT01689194 | Seoul National University Hospital | Phase 2 |