| Recruiting | Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burs NCT07026461 | Region Örebro County | Phase 4 |
| Not Yet Recruiting | Mental Health Mission Mood Disorder Cohort Study NCT07189689 | University of Oxford | — |
| Recruiting | Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality NCT06706232 | The University of Texas Health Science Center, Houston | Phase 2 |
| Enrolling By Invitation | Digital Phenotypes for Predicting Depression NCT07151846 | Korea University Anam Hospital | — |
| Recruiting | Precision Subclassification of Mental Health in Diabetes: Digital Twins for Precision Mental Health to Track S NCT07212075 | Forschungsinstitut der Diabetes Akademie Mergentheim | — |
| Recruiting | Natural History of Depression, Bipolar Disorder and Suicide Risk NCT06462196 | National Institute of Mental Health (NIMH) | — |
| Recruiting | BioClock: Bright Light Therapy for Depressive Disorders NCT05958940 | Universiteit Leiden | N/A |
| Not Yet Recruiting | Ketogenic Diet for Depression NCT06105762 | University Psychiatric Clinics Basel | N/A |
| Recruiting | Lithium Versus Cariprazine in the Acute Phase Treatment of Bipolar Depression (DUAG9) NCT05913947 | Aalborg University Hospital | Phase 4 |
| Unknown | Biomarkers of ANTidepressant RESponse and Development Risk of Bipolar Disorder NCT05568823 | Assistance Publique Hopitaux De Marseille | N/A |
| Completed | Transcranial Direct Current Stimulation Therapy for Bipolar Depression NCT05436613 | University of East London | N/A |
| Unknown | Recovering Damaged Cells for Sequelae Caused by COVID-19, SARS-CoV-2 NCT04846010 | All Natural Medicine Clinic, LLC | Phase 1 / Phase 2 |
| Suspended | IM Ketamine vs Midazolam for Suicidal ER Patients NCT04640636 | New York State Psychiatric Institute | Phase 4 |
| Completed | Music as an Intervention to Improve Hemodynamic Tolerability of Ketamine in Depression NCT04701866 | Douglas Mental Health University Institute | N/A |
| Recruiting | LIVES: Personalized Lifestyle Intervention for Patients With Depression NCT05767073 | University Medical Center Groningen | N/A |
| Unknown | The Effect of S-ketamine for Patients Undergoing Electroconvulsive Therapy (ECT) NCT04399070 | Yan Qiu | N/A |
| Recruiting | Optimal Electrical Stimulus During Electroconvulsive Therapy NCT04057378 | Region Örebro County | Phase 4 |
| Completed | Pramipexole to Target "Anhedonic Depression" NCT04121091 | Region Skane | Phase 2 |
| Unknown | Management of my Bipolarity Intervention in Bipolar Disorder Patients NCT04643210 | Cyprus University of Technology | N/A |
| Completed | Chronobiology and Depression: Circadian Analytics as a Biomarker for Depressive Subtypes NCT03538275 | Medibio Limited | — |
| Recruiting | A Study of Abilify® Tablet(Aripiprazole) as an Adjunctive Treatment in the Bipolar Depression NCT03423680 | Korea Otsuka Pharmaceutical Co., Ltd. | Phase 3 |
| Completed | The Effects of tDCS on Depressive Symptoms,Neurocognitive Function and HRV in Unipolar Depression and Bipolar NCT03287037 | Tri-Service General Hospital | N/A |
| Completed | Magnetic Resonance Spectroscopy (MRS) in Midlife Depression NCT02567110 | Emory University | — |
| Enrolling By Invitation | Study of a Vestibular Biomarker of Phase in Bipolar Disorder NCT02827045 | Vest Brain,Centro de Estudios Neurovestibulares | — |
| Recruiting | Dallas 2K: A Natural History Study of Depression NCT02919280 | University of Texas Southwestern Medical Center | — |
| Recruiting | Study of the Effectiveness of Vestibular Stimulation Treatment in the Depressive Phase of Bipolar Disorder NCT02778256 | Vest Brain,Centro de Estudios Neurovestibulares | N/A |
| Terminated | Long Term Follow-up of Deep Brain Stimulation for Treatment-Resistant Depression NCT03360942 | Dartmouth-Hitchcock Medical Center | N/A |
| Withdrawn | Combined Cytidine and Creatine-containing Drug in the Treatment of the Bipolar Depression NCT02625779 | Ewha Womans University Mokdong Hospital | Phase 2 |
| Completed | Pharmacogenetic Implementation Trial in Veterans With Treatment Refractory Depression NCT04469322 | San Diego Veterans Healthcare System | N/A |
| Completed | Transcranial Direct Current Stimulation for the Treatment of Bipolar Depression NCT02152878 | University of Sao Paulo | Phase 2 / Phase 3 |
| Completed | Deep Brain Stimulation (DBS) for Treatment-Resistant Depression (TRD) NCT01898429 | Paul Holtzheimer | N/A |
| Completed | Safety, Tolerability, and Efficacy of Cariprazine in Participants With Bipolar Depression NCT01396447 | Forest Laboratories | Phase 2 |
| Completed | An Investigation of Sleep Architecture in Ziprasidone-Treated Bipolar Depression NCT00835107 | Queen's University | Phase 4 |
| Completed | Efficacy of Olanzapine Monotherapy for Treatment Bipolar Ⅰ Depression NCT01303601 | China Medical University, China | Phase 4 |
| Completed | Lamotrigine for Symptoms of Geriatric Bipolar Depression NCT00621842 | University Hospitals Cleveland Medical Center | Phase 3 |
| Completed | Functional and Neurochemical Brain Changes Bipolar Depression NCT00608296 | University of Cincinnati | — |
| Active Not Recruiting | Light-Therapy in the Treatment of the Acute Phase of the Bipolar Type II Depression NCT00590265 | Douglas Mental Health University Institute | N/A |
| Completed | Adjunctive Ziprasidone in the Treatment of Bipolar I Depression NCT00483548 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Phase 3 |
| Completed | Olanzapine Treatment of Patients With Bipolar I Disorder NCT00510146 | Eli Lilly and Company | Phase 3 |
| Completed | Phase III/Seroquel SR Bipolar Depression Monotherapy - US NCT00422214 | AstraZeneca | Phase 3 |
| Completed | Study Evaluating Bifeprunox in Bipolar Depression NCT00245973 | Wyeth is now a wholly owned subsidiary of Pfizer | Phase 3 |
| Completed | Bipolar Depression Study: Bipolar Depression Assessment Study on Treatment Response NCT00191399 | Eli Lilly and Company | Phase 4 |
| Completed | Depakote ER in Bipolar Depression NCT00186186 | Stanford University | Phase 4 |
| Completed | Safety and Efficacy Trial of the Use of Quetiapine Fumarate (SEROQUEL®) in the Treatment of Patients With Bipo NCT00060489 | AstraZeneca | Phase 3 |