| Not Yet Recruiting | The Coma Family Program (COMA-F): A Resilience Program for Caregivers of Patients With Severe Acute Brain Inju NCT07331324 | Massachusetts General Hospital | N/A |
| Not Yet Recruiting | fNIRS for Disorders of Consciousness NCT07485361 | University of California, Los Angeles | — |
| Not Yet Recruiting | Assessment of Structural Brain Changes Related to Anoxic Coma Using High-field and Very Low Field Mobile MRI NCT07177755 | University Hospital, Toulouse | N/A |
| Not Yet Recruiting | The Safety and Efficacy of Median Nerve Electrical Stimulation for Improving Neurological Function Prognosis i NCT06696690 | Tang Ziren | N/A |
| Recruiting | Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation-2 (TELSTAR-2) NCT06549426 | University of Twente | N/A |
| Active Not Recruiting | Evaluation and Optimization of Telephone Triage Using Artificial Intelligence (AI) Models for the Detection of NCT07247669 | Centro de Emergencias Sanitarias 061 Andalucía | — |
| Not Yet Recruiting | Combined Whole-brain Structural and Functional MRI for the Prediction of Neurological Recovery After Cardiac A NCT06617377 | University Hospital, Toulouse | N/A |
| Completed | Comparison Between GCS and FOUR Scores NCT06703619 | Al-Nahrain University | — |
| Not Yet Recruiting | Evaluation of EEG Power Spectrum in Patients With Traumatic Coma NCT06321146 | RenJi Hospital | — |
| Completed | The COMA Family Program: A Skills-Based Resiliency Program for Caregivers of Patients With Severe Acute Brain NCT05761925 | Massachusetts General Hospital | N/A |
| Completed | Effectiveness of Familiar Voices and Nature Sounds Among Critically Ill Comatose Patients NCT06470802 | Vo Thi Hong Nhan | N/A |
| Active Not Recruiting | Comprehensive Observations and Multidisciplinary Approaches in the Management of Unconscious Patients NCT06265168 | University Hospital, Basel, Switzerland | — |
| Active Not Recruiting | Predicting Mortality in Patients With Return of Spontaneous Circulation After Cardiac Arrest NCT07020091 | Ahmet Düzgün | — |
| Terminated | Antiseizure Medication in Seizure Networks at Early Acute Brain Injury NCT06081283 | University of North Carolina, Chapel Hill | Phase 4 |
| Recruiting | Predictive Outcome in Comatose Patients NCT05321459 | Assistance Publique - Hôpitaux de Paris | — |
| Active Not Recruiting | Feasibility of the Comfort Measures Only Time Out (CMOT) NCT05861323 | Beth Israel Deaconess Medical Center | N/A |
| Unknown | A New Approach in Intensive Care Unit Consciousness Assessment: FIVE Score NCT06036732 | Istanbul University - Cerrahpasa | — |
| Recruiting | Short-term Cervical Spinal Cord Stimulation in Patients With Disorders of Consciousness After Intracerebral He NCT05922644 | Beijing Tiantan Hospital | N/A |
| Completed | Brain Death and Organ Donation in Tunisian Intensive Care Units NCT06948669 | Faculty of Medicine, Sousse | — |
| Recruiting | Rapid-Response EEG in Children With Suspected Status Epilepticus NCT06564662 | Children's Hospital at Montefiore | — |
| Completed | VIGABatrin in Post-anoxic STATus Epilepticus - Phase IIa NCT04772547 | University of Florida | Phase 2 |
| Recruiting | Direct or Subacute Coronary Angiography in Patients With Out of Hospital Cardiac Arrest Without Coma. NCT04876222 | Aarhus University Hospital Skejby | N/A |
| Withdrawn | Tracheostomy With Bedside Simultaneous Gastrostomy Vs Usual Care Tracheostomy And Delayed Gastrostomy Placemen NCT04758052 | University of Mississippi Medical Center | N/A |
| Unknown | Role of Intravenous Lipid Emulsion in Improving Coma of Acute Antipsychotics Poisoning NCT04807634 | Ain Shams University | N/A |
| Completed | Neurological Complications and ICU Workload After Emergency Repair of Acute Type A Aortic Dissection NCT07167628 | China Medical University Hospital | — |
| Unknown | Online Noninvasive Assessment of Human Brain Death and Deep Coma by Near-infrared Spectroscopy NCT04623294 | Chinese Academy of Medical Sciences | — |
| Unknown | Factors Associated With CPC 1-2 in 110 Patients Admitted in French ICU for a Myocardial Infarction Complicated NCT04584463 | Central Hospital, Nancy, France | — |
| Active Not Recruiting | Stimulant Therapy Targeted to Individualized Connectivity Maps to Promote ReACTivation of Consciousness NCT03814356 | Massachusetts General Hospital | Phase 1 |
| Completed | Prognostication of Recovery in Early Disorders of Consciousness After COVID-19 NCT04476589 | Massachusetts General Hospital | — |
| Terminated | EASiVENT Study Comparing INTELLiVENT-ASV vs Non Automated Ventilation in Adult ICU Patients NCT04400643 | Hamilton Medical AG | — |
| Completed | Effect of Minocycline on Delirium Incidence in Critically Ill Patients NCT04219735 | Universidade do Extremo Sul Catarinense - Unidade Academica de Ciecias da Saude | Phase 2 |
| Unknown | Fluctuation of Rhymicity to Predict Recovery NCT04444648 | Hospices Civils de Lyon | — |
| Unknown | Development of a Point of Care System for Automated Coma Prognosis NCT03826407 | McMaster University | — |
| Completed | Carbon Monoxide-induced Coma: Prognostic Factors NCT03926494 | Assistance Publique - Hôpitaux de Paris | — |
| Terminated | The Use of a Point-of-care Thoracic Ultrasound Protocol for Hospital Medical Emergency Teams NCT03214809 | Rijnstate Hospital | N/A |
| Completed | Aggressive Antipyretics for Fever Reduction in CNS Malaria NCT03399318 | University of Rochester | Phase 2 |
| Completed | International Observational Study on Airway Management in Critically Ill Patients NCT03616054 | Azienda Ospedaliera San Gerardo di Monza | — |
| Completed | REsting and Stimulus-based Paradigms to Detect Organized NetworkS and Predict Emergence of Consciousness NCT03504709 | Massachusetts General Hospital | — |
| Active Not Recruiting | Lassa Fever Clinical Course and Prognostic Factors in Nigeria NCT03655561 | Alliance for International Medical Action | — |
| Withdrawn | Clinical Study of the LRS ThermoSuit™ System in Post Arrest Patients With Intravenous Infusion of Magnesium Su NCT00593164 | Life Recovery Systems | Phase 2 |
| Completed | Key to Improve DiagNosis in Aspiration Pneumonia NCT03182387 | University Hospital, Bordeaux | — |
| Completed | Continuous EEG Randomized Trial in Adults NCT03129438 | Andrea Rossetti, MD | N/A |
| Completed | Improving Awakening Prognostication After Non Anoxic Coma Using PET-MRI in Intensive Care Unit NCT02798588 | Hospices Civils de Lyon | N/A |
| Unknown | Amantadine and Functional Improvement Following ABI Measured by MRI Tractography; A Pilot Study NCT02566720 | Hamilton Health Sciences Corporation | N/A |
| Completed | Continuous Quantified EEG in NeuroIntensive Care NCT02901262 | Azienda Ospedaliera San Gerardo di Monza | — |
| Completed | Amantadine to Speed Awakening After Cardiac Arrest NCT02486211 | Jon Rittenberger, MD | Phase 2 |
| Completed | Feasibility of Mini-EEG in the Prehospital Setting NCT02329028 | Helsinki University Central Hospital | — |
| Unknown | Optic Nerve Sheath Diameter as a Screening Test for Increased Intracranial Pressure NCT02338284 | King Faisal Specialist Hospital & Research Center | — |
| Completed | Study of Body Positions in Unconsciousness NCT02427633 | University of Oxford | N/A |
| Completed | GLP-1 Analogs for Neuroprotection After Cardiac Arrest NCT02442791 | Jesper Kjaergaard | N/A |
| Completed | Succinylcholine vs Rocuronium for Prehospital Emergency Intubation NCT02000674 | Centre Hospitalier Universitaire de la Réunion | Phase 3 |
| Completed | Cognitive Auditory Evoked Potential After Cardiac Arrest: Interest of Mismatch negativiTY NCT01980446 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | The Checklist for Early Recognition and Treatment of Acute Illness (CERTAIN) NCT01973829 | Mayo Clinic | N/A |
| Completed | Using EEG to Study Coma in the Neurocritical Care Unit NCT01897194 | University of Utah | — |
| Completed | Beneficial Effects of Music on Cognition and Consciousness Level NCT02742506 | Hospices Civils de Lyon | N/A |
| Completed | Patient Centered Cloud-based Electronic System: Ambient Warning and Response Evaluation (ProCCESs AWARE) NCT02039297 | Mayo Clinic | N/A |
| Completed | Midazolam Whole Body Physiologically Based Pharmacokinetic Model NCT01973894 | Università degli Studi dell'Insubria | — |
| Completed | Longitudinal Study of the Default-mode Network Connectivity in Brain Injured Patients Recovering From Coma NCT01620957 | Institut National de la Santé Et de la Recherche Médicale, France | — |
| Active Not Recruiting | Norwegian Cardio-Respiratory Arrest Study NCT01239420 | Oslo University Hospital | — |
| Completed | Evaluation of Essential Surgical Skills-Emergency Maternal and Child Health Training NCT00880204 | Child Advocacy International | N/A |
| Completed | The Efficacy of Familiar Voice Stimulation During Coma Recovery NCT00557076 | VA Office of Research and Development | N/A |
| Completed | Out-of-Hospital Intubation With Metal Single Use Laryngoscope Blades NCT00644722 | Henri Mondor University Hospital | Phase 4 |
| Completed | Pilot Clinical Study of the LRS ThermoSuit™ System in Post Arrest Patients NCT00410969 | Life Recovery Systems | Phase 1 |
| Completed | Cervical Spine Clearance in Obtunded Trauma Patients NCT00573014 | MetroHealth Medical Center | — |
| Completed | Multimodal Resonance Imaging for Outcome Prediction on Coma Patients NCT00577954 | Assistance Publique - Hôpitaux de Paris | — |
| Completed | Optimized Therapy in Severe Traumatic Brain Injured Patients NCT02130674 | University of Zurich | Phase 4 |
| Completed | Comparison of Central and Peripheral Venous Catheters NCT00122707 | Assistance Publique - Hôpitaux de Paris | N/A |
| Completed | Use of Music and Voice Stimulus on Coma Patients NCT00959829 | University of Sao Paulo | N/A |
| Terminated | Intrathecal Baclofen Therapy and Paroxysmal Dysautonomia in Severe Brain-Injured Patients NCT00221689 | University Hospital, Bordeaux | Phase 2 |