| Not Yet Recruiting | Calcium Dobesilate After Radiofrequency Ablation for Varicose Veins NCT07390097 | Oguz Arslanturk | Phase 4 |
| Recruiting | The Influence of Laser Crossectomy With Different Wavelengths on Varicose Vein Progression NCT07449728 | Pirogov Russian National Research Medical University | N/A |
| Not Yet Recruiting | Clinical Study in Adult Patients With Purulent-inflammatory Processes of the Skin and Soft Tissues, Phase I-II NCT06232421 | Research Institute for Physical Chemical Problems of the Belarusian State University | Phase 2 / Phase 3 |
| Completed | Clinical Trial of Aesculus Hippocastanum and Associations Versus Diosmina and Hesperidina in Chronic Venous In NCT06579482 | Fundação Educacional Serra dos Órgãos | Phase 4 |
| Recruiting | Clinical Study to Evaluate the Effectiveness and Health Economics of a Novel Portable Non-Pneumatic Active Com NCT06418282 | Koya Medical, Inc. | N/A |
| Active Not Recruiting | Respiratory and Physical Functions in Individuals With Chronic Venous Insufficiency NCT06196541 | Izmir Democracy University | — |
| Completed | Extracorporeal Flow Abolition in Relation With Primary Insufficiency of Great Saphenous Veins (GSV) Using High NCT05926830 | Theraclion | N/A |
| Completed | Plantar Pressure Analysis and Foot Biomechanics in Lipedema and Chronic Venous Disease NCT06238791 | Hacettepe University | — |
| Terminated | Long-term Effects of Inspiratory Muscle Training in Chronic Venous Insufficiency NCT05982405 | Izmir Democracy University | N/A |
| Active Not Recruiting | Venclose digiRF System Post Market Study NCT05504070 | C. R. Bard | N/A |
| Completed | A Non-randomized, Open-Label Study to Evaluate the Safety and Effectiveness of Insight® Pro Device for Evaluat NCT05628688 | Koya Medical, Inc. | — |
| Completed | Inspiratory Muscle Training in Chronic Venous Diseases NCT05993650 | Izmir Democracy University | N/A |
| Unknown | Daily Duration of Compression Treatment in Patients With Symptomatic Chronic Venous Disease NCT06175546 | Pirogov Russian National Research Medical University | N/A |
| Unknown | National Varicose Vein Study - Portugal NCT05625074 | Universidade do Porto | — |
| Withdrawn | Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System (INFINITE-Canada) NCT05047302 | Intervene, Inc. | N/A |
| Completed | Efficacy of Active Versus Passive Methods in Chronic Venous Insufficiency NCT05383469 | Istanbul University - Cerrahpasa | N/A |
| Completed | A Clinical Study to Evaluate the Effectiveness of a Novel Portable Non-Pneumatic Active Compression Device vs. NCT05507346 | Koya Medical, Inc. | N/A |
| Terminated | Best Endovenous Treatment, Including STenting, Versus Non-endovenous Treatment in Chronic Proximal Deep Venous NCT05622500 | Imperial College London | N/A |
| Completed | Assessment of the Effect of Spa Therapy on the Quality of Life of Patients with Chronic Venous Insufficiency ( NCT05449743 | Le Syndicat Intercommunal pour le Thermalisme et l'Environnement | N/A |
| Unknown | Assessment of the Relationship Between Severity of Chronic Venous Obstruction and Venous Claudication NCT05662761 | RWTH Aachen University | — |
| Unknown | High Intensity Focused Ultrasound in PAtients With Varicose Veins in Singapore NCT04339088 | Singapore General Hospital | — |
| Unknown | Tissue Engineered Veins in Patients With Chronic Venous Insufficiency NCT03784131 | Verigraft AB | Phase 1 |
| Completed | The Effect of Inelastic Compression System on Quality of Life in People With Chronic Venous Insufficiency NCT05051540 | University of Miami | N/A |
| Completed | Study to Evaluate the Safety and Effectiveness of Dayspring for Lower Extremity Lymphedema NCT04897035 | Koya Medical, Inc. | N/A |
| Completed | The Evaluation of the Pathophysiology of Varicose Veins in Pregnancy NCT05058989 | Imperial College London | — |
| Unknown | Evaluation of Pain Associated With Chronic Venous Insufficiency NCT04794712 | Imperial College London | — |
| Completed | VAP-PRO-C6. Effectiveness and Tolerability of Venoactive Drugs in Combination Therapy in Patients With CVD (CE NCT04757766 | Servier Russia | — |
| Completed | Venous Stent for the Iliofemoral Vein Investigational Clinical Trial Using the DUO Venous Stent System NCT04580160 | Vesper Medical, Inc. | N/A |
| Completed | Venclose RF Ablation System for the Treatment of IPVs NCT04386785 | Venclose, Inc. | N/A |
| Completed | EU Post Market Clinical Follow-Up Study of the Venclose System for Saphenous Vein Incompetence NCT04236245 | Venclose, Inc. | N/A |
| Unknown | Venous Disease in Pediatric Population NCT04424095 | University of Catanzaro | — |
| Recruiting | Feasibility of the InnoVein Valve and Delivery System for Chronic Venous Insufficiency NCT04253301 | InnoVein | N/A |
| Active Not Recruiting | Elastic Compression Stockings and Varicose Veins Recurrence NCT04231942 | Pirogov Russian National Research Medical University | N/A |
| Unknown | Registry to Investigate the Efficacy and Safety of VenaBlock VeIn SEaling System for VaRicose Veins in SingApo NCT04339075 | Singapore General Hospital | — |
| Terminated | EdemaWear to Reduce Edema in Hospitalized Patients With CVI: NCT03904602 | Massachusetts General Hospital | N/A |
| Unknown | Efficacy and Safety of Endovenous Radio Frequency (EVRF) for Treatment of Varicose Veins in Singapore NCT04384315 | Singapore General Hospital | — |
| Unknown | Cyanoacrylate Closure Versus Surgical Stripping for Incompetent Saphenous Veins NCT03835559 | Kyung Hee University Hospital at Gangdong | N/A |
| Unknown | Compression Stockings Therapy Following Mechano-Chemical Ablation (Clarivein®) NCT03685838 | Singapore General Hospital | N/A |
| Unknown | Sex Dysfunction and Chronic Venous Disease NCT05749471 | University of Catanzaro | — |
| Unknown | The Effect of Structured Exercise on Chronic Venous Insufficiency NCT03562546 | Shannon Hernon | N/A |
| Completed | A Singapore Venaseal Real World Post-Market Evaluation Study NCT03893201 | Singapore General Hospital | — |
| Unknown | Study to Evaluate Impact SANKOM Patent Socks in Patients With CVI NCT03445091 | Sankom SA | N/A |
| Unknown | Ecchymosis and Coldness in Patients With Varicose Vein NCT03384355 | Vascular and Molecular Cardiology Society | — |
| Recruiting | Investigation of Femoropopliteal In Situ Valve Formation With the InterVene System NCT03216005 | Intervene, Inc. | N/A |
| Unknown | Study to Assess the Efficacy and Safety of Endolex Forte VErsus Diosmin and Hesperidin in Reducing VeNous Insu NCT02927483 | SunWave Pharma | Phase 3 |
| Withdrawn | SPA Therapy in the Treatment of Sleep Apnea Syndrome NCT02559427 | Association Francaise pour la Recherche Thermale | N/A |
| Unknown | Effect of Standing, Lying and Stockings on Blood Bio-markers (v.1) NCT02662127 | London North West Healthcare NHS Trust | N/A |
| Completed | Copper Impact on Venous Insufficiency and Lipodermatosclerosis NCT03283800 | Croydon Health Services NHS Trust | N/A |
| Terminated | A Feasibility Study of the ReLeaf Catheter System NCT02462096 | Intervene, Inc. | N/A |
| Completed | Prevalence of Chronic Venous Disease in General Population NCT03900234 | Pirogov Russian National Research Medical University | — |
| Completed | SeCure Endovenous Laser Treatment Study NCT02215369 | Angiodynamics, Inc. | N/A |
| Completed | Evaluation of a Dual Action Pneumatic Compression System: Tolerance and Comfort in Patients With Venous Leg Ul NCT02395302 | Tactile Medical | N/A |
| Completed | Outpatient Office Based Endovascular Procedures NCT04054440 | Methodist Health System | — |
| Completed | Evaluation of a Dual Action Pneumatic Compression Device: Patient Ease of Use and Comfort NCT02015221 | Tactile Medical | N/A |
| Completed | Efficacy and Safety of Esarin Gel in Chronic Venous Insufficiency and Varicose Veins NCT02346058 | Ten Sun Pharma Company Limited | Phase 4 |
| Completed | Manual Lymphatic Drainage in Chronic Venous Insufficiency: a Randomized Controlled Trial NCT01899482 | Technical University of Lisbon | N/A |
| Completed | LLLT of Trophic Ulcers of Lower Extremities and Chronic Venous Insufficiency NCT03104985 | Research Center Matrix | N/A |
| Completed | Efficacy and Safety of Coumarin and Troxerutin in the Symptomatic Treatment of Chronic Venous Insufficiency NCT01848210 | Takeda | Phase 4 |
| Completed | Study of Antiinflammatory Effects of Detralex (Daflon) NCT01654016 | University Hospital Dubrava | Phase 4 |
| Unknown | Validation of a New Method of Limb Volumetry NCT01574911 | University Hospital, Montpellier | — |
| Unknown | Study to Evaluate the Efficacy and Tolerability of Venaflon Use in Reducing the Symptoms Caused by Chronic Ven NCT01477281 | Laboratório Teuto Brasileiro S/A | Phase 3 |
| Completed | Chronic Venous Insufficiency; Impact of Compression Stockings on Quality of Life NCT02050061 | Qassim University | N/A |
| Unknown | Efficacy and Tolerability of the Use of Varicell Compared With Daflon NCT01321619 | Vidfarma Indústria de Medicamentos Ltda. | Phase 3 |
| Completed | Neuromuscular Electrical Therapy in Venous Ulcers NCT01372020 | Faculdade Evangelica do Parana | Phase 4 |
| Completed | Practicability of Gliding Aids for Medical Compression Stockings NCT01432795 | University of Zurich | Phase 4 |
| Unknown | Venous Pressure Measurement of the Great Saphenous Vein Using Controlled Compression Ultrasound in Healthy Per NCT01000909 | University of Zurich | — |
| Completed | Efficacy Study of Kinesio Taping to Treat Muscular and Joint Problems in Chronic Venous Insufficiency NCT01501188 | Universidad de Granada | Phase 1 |
| Completed | Radiofrequency Ablation vs Laser Ablation of the Incompetent Greater Saphenous Vein NCT02236338 | Virginia Commonwealth University | Phase 4 |
| Terminated | Radiofrequency Ablation vs. Laser Ablation of the Incompetent Small Saphenous Vein NCT02248740 | Virginia Commonwealth University | Phase 4 |