| Recruiting | A Study to Assess Adverse Events and Change in Disease Activity of Oral Icalcaprant in Adult Participants With NCT06696755 | AbbVie | Phase 2 |
| Recruiting | Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder NCT07213466 | Mayo Clinic | Phase 4 |
| Enrolling By Invitation | An Open-label Study of Azetukalner in Bipolar I or II Depression (X-CEED-OLE) NCT07217860 | Xenon Pharmaceuticals Inc. | Phase 3 |
| Recruiting | A Randomized Study of Azetukalner Versus Placebo in Depressive Episodes Associated With Bipolar I or II Disord NCT07172516 | Xenon Pharmaceuticals Inc. | Phase 3 |
| Recruiting | Closed-Loop Deep Brain Stimulation for Treatment-Resistant Bipolar Depression NCT07127913 | Andrew Krystal | N/A |
| Recruiting | Acceptability & Safety of Two Sequential Doses of Psilocybin in Bipolar Disorder II Depression and Suicidality NCT06706232 | The University of Texas Health Science Center, Houston | Phase 2 |
| Completed | Assessment of Acute Psychomotor Agitation Measures Associated With Schizophrenia and Bipolar Disorder NCT07116694 | BioXcel Therapeutics Inc | Phase 2 |
| Not Yet Recruiting | SYNCED - SYNChronized Eating in Bipolar Depression Study NCT06560957 | University of Ottawa | N/A |
| Recruiting | LHC-CIDI-5 in Hong Kong NCT06804525 | The University of Hong Kong | — |
| Completed | Study of Oral ABBV-932 to Assess Adverse Events and Change in Disease Activity in Adult Participants With Bipo NCT06605599 | AbbVie | Phase 2 |
| Recruiting | Lithium Versus Lamotrigine in Bipolar Disorder, Type II NCT06184581 | University Hospital Bispebjerg and Frederiksberg | Phase 4 |
| Suspended | CBT for Problematic Impulsive Behaviours in Bipolar Disorder: A Case Series / CBT-PIB NCT06129500 | University of Exeter | N/A |
| Terminated | Phase 2 Clinical Trial of GH001 in Bipolar II Disorder NCT05839509 | GH Research Ireland Limited | Phase 2 |
| Unknown | Impact of a Ketogenic Diet on Metabolic and Psychiatric Health in Patients With Bipolar Illness NCT05705063 | Stanford University | N/A |
| Completed | Dexmedetomidine in the Treatment of Agitation Associated With Schizophrenia and Bipolar Disorder (SERENITY III NCT05658510 | BioXcel Therapeutics Inc | Phase 3 |
| Suspended | Braining- Aerobic Physical Activity as Add on Treatment in Bipolar Depression NCT05340686 | Region Stockholm | N/A |
| Completed | Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression NCT05339074 | Joshua Rosenblat | Phase 2 |
| Completed | Ketamine for Treatment-Resistant Bipolar Disorder NCT05004896 | Joshua Rosenblat | Phase 2 |
| Recruiting | Children's Bipolar Network Treatment Trial I NCT05427123 | University of California, Los Angeles | — |
| Completed | Efficacy of the Mobile Application for Prediction and Prevention of Mood Episode Recurrence Based on Machine L NCT05400785 | Hucircadian | N/A |
| Completed | Evaluating the Hypothesized Mechanism of Action of N-acetylcysteine for Bipolar Disorder NCT05340504 | Medical University of South Carolina | Phase 2 |
| Recruiting | Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders NCT05064319 | Medical University of South Carolina | Phase 2 |
| Active Not Recruiting | Psilocybin Therapy for Depression in Bipolar II Disorder NCT05065294 | University of California, San Francisco | Phase 2 |
| Unknown | The Effect of Interpersonal Relationships and Social Rhythm Therapy Individuals With Bipolar Disorder NCT05420792 | Ege University | N/A |
| Unknown | Naturalistic Study of Ketamine in the Treatment of Depression NCT05249309 | Hospital de Clinicas de Porto Alegre | — |
| Unknown | Emotional Proactive Processing in Bipolar Disorder NCT04561622 | University Hospital, Grenoble | — |
| Withdrawn | A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Bipolar Disorder NCT04211428 | ProgenaBiome | — |
| Unknown | add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients NCT04035798 | National Cheng-Kung University Hospital | Phase 2 / Phase 3 |
| Completed | Treating Smokers With Mental Illness NCT03822416 | University of Minnesota | Phase 2 |
| Completed | Efficacy of Convulsive Therapies for Bipolar Depression NCT03641300 | Centre for Addiction and Mental Health | N/A |
| Unknown | Continuous Theta Burst Stimulation as an add-on Treatment for Bipolar Depression NCT03603561 | Universiteit Antwerpen | N/A |
| Active Not Recruiting | Low Field Magnetic Stimulation: Imaging Biomarkers in Geriatric Bipolar Depression NCT03484494 | Mclean Hospital | N/A |
| Completed | Gabapentin for Bipolar & Cannabis Use Disorders NCT03334721 | Medical University of South Carolina | Phase 2 |
| Completed | The BIO-K Study: A Single-Arm, Open-Label, Biomarker Development Clinical Trial of Ketamine for Non-Psychotic NCT03156504 | Mayo Clinic | Phase 4 |
| Completed | Differential Responses to Drugs and Sweet Tastes NCT03810703 | University of Chicago | Phase 1 |
| Completed | Effect of Ketamine vs. Active Placebo on Suicidal Ideation in Depressed Inpatients With Major Depressive Disor NCT02593643 | Sunnybrook Health Sciences Centre | EARLY_Phase 1 |
| Terminated | Ginger.io Behavioral Health Study NCT02491307 | Community Health Center, Inc. | N/A |
| Completed | Study of Lurasidone in Treating Antipsychotic Naive or Quasi-Naive Children and Adolescents NCT01731119 | University of North Carolina, Chapel Hill | Phase 2 |
| Completed | Sequential Multiple Assignment Treatment for Bipolar Disorder NCT01588457 | The University of Texas Health Science Center at San Antonio | Phase 4 |
| Completed | Prevention of Weight Gain in Early Psychoses NCT01075295 | Centre for Addiction and Mental Health | N/A |
| Completed | Sensoril(Ashwaganhda)for Bipolar Disorder NCT00761761 | University of Pittsburgh | Phase 3 |
| Completed | Seroquel in the Treatment of Dysphoric Hypomania in Bipolar II NCT00186043 | Stanford University | Phase 4 |
| Completed | Psychotherapy for Bipolar II Depression, Pilot Study, Phase II NCT00411463 | University of Pittsburgh | Phase 2 / Phase 3 |
| Completed | Open-Label Study of Geodon in Non-Rapid Cycling Bipolar II Patients With Major Depression NCT00237666 | The Medical Research Network | Phase 4 |