| Not Yet Recruiting | Comparison of Anesthetic Techniques for Early Recovery After Ankle Arthroscopy NCT07460310 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Not Yet Recruiting | the Efficacy of Hyperbaric Oxygen on Acute Ankle Sprain NCT07405281 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Completed | Counterpain PXM Versus Diclofenac Versus Piroxicam NCT07475663 | Taisho Pharmaceutical Indonesia | Phase 3 |
| Not Yet Recruiting | Validation of a Portable Ankle Arthrometer NCT07163897 | University of Virginia | — |
| Recruiting | NMES With PNF for Ankle Sprain Rehabilitation NCT07190599 | Fooyin University | N/A |
| Not Yet Recruiting | Validity and Reliability of Calf Raise Tests in Patients With Achilles Tendon Rupture and Lateral Ankle Sprain NCT07197593 | Schulthess Klinik | N/A |
| Recruiting | A Study on Reducing Opioid Use After Minimally Invasive Ankle Surgery NCT07154433 | Second Affiliated Hospital, School of Medicine, Zhejiang University | N/A |
| Recruiting | Surgical Management of Lateral Ankle Instability: Modified Broström-Gould Versus Arthroscopic Allograft Recons NCT07200271 | Universidad Francisco de Vitoria | N/A |
| Recruiting | Semiconductor Embedded Socks for Ankle Sprains NCT07025733 | University of Colorado, Denver | N/A |
| Completed | Systematic Ultrasound in the Initial Assessment of Ankle Sprain NCT06856889 | Hopital Nord Franche-Comte | — |
| Completed | Efficacy of Tecar Device With Exercises in Ankle Sprain NCT06934629 | Cairo University | N/A |
| Completed | Impact of Chronic Ankle Instability on Jumping and Agility in Athletes NCT07171398 | Ankara Yildirim Beyazıt University | — |
| Active Not Recruiting | Topical Treatments for Ankle Sprains NCT06623929 | Ankara City Hospital Bilkent | — |
| Completed | Auto-regulated Blood Flow Restriction in Athletes With Recurrent Ankle Sprain NCT06962943 | Prince Sattam Bin Abdulaziz University | N/A |
| Completed | Effectiveness of a Telerehabilitation Program in Ankle Sprain NCT05217173 | Instituto Mexicano del Seguro Social | N/A |
| Recruiting | Comparison of MBR + Suture Tape and MBR for CLAI in GJL Cases: A Prospective Cohort Study NCT06897293 | Peking University Third Hospital | — |
| Recruiting | Computed Tomography with Stress Maneuvers for Evaluation of Distal Tibiofibular Syndesmosis Instability (CTMET NCT04095598 | Hospital Israelita Albert Einstein | — |
| Completed | TRAUMED - a Clinical Trial in Acute Ankle Sprain NCT06192420 | Biologische Heilmittel Heel GmbH | Phase 3 |
| Terminated | Proof-of-concept Study of NSAID Hydrogel Patch in Treatment of Acute Pain NCT02729207 | Teikoku Seiyaku Co., Ltd. | Phase 2 |
| Completed | Effect of Elastic Bandage on Balance in Chronic Ankle Instability NCT02682303 | Universidad Rey Juan Carlos | N/A |
| Unknown | Ketoprofen Gel vs Placebo in Children With Ankle Sprain NCT02491736 | Akdeniz University | Phase 4 |
| Unknown | Neurocryostimulation for Acute Lateral Ankle Sprain NCT02945618 | Laval University | N/A |
| Completed | Validation of the Foot and Ankle Ability Measure Tool in Finnish NCT02330198 | Turku University Hospital | — |
| Completed | Topical Ketoprofen Versus Placebo in Patients With Ankle Sprain NCT02393846 | Akdeniz University | Phase 4 |
| Completed | Impact of Six Patient Information Leaflets (PIL) on Doctor Patient Communication NCT02246361 | Floralis | Phase 4 |
| Completed | Assessing Foot Injuries in Infantry Recruits Wearing Different Boots NCT02810002 | Medical Corps, Israel Defense Force | Phase 1 / Phase 2 |
| Completed | Safety and Efficacy of Generic Diclofenac Epolamine Acute Pain Due to Minor Ankle Sprain NCT02324270 | Actavis Inc. | Phase 3 |
| Completed | Influence of Sensorimotor Treatment in the Balance of Soccer NCT02097940 | Universidade Estadual de Londrina | N/A |
| Completed | Efficacy of Topical Indomethacin Patch Over Placebo in Ankle Sprain Pain Relief NCT01957215 | GlaxoSmithKline | Phase 4 |
| Completed | Management of Acute Ankle Sprain With Sodium Hyaluronate NCT02091674 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Phase 2 |
| Completed | Effect of Kinesio® Taping in Chronic Ankle Instability NCT02266290 | Universidad Rey Juan Carlos | N/A |
| Completed | Study of Effects of Electroacupuncture on Balance in Subjects With Chronic Functional Ankle Instability NCT02056795 | Canadian Memorial Chiropractic College | N/A |
| Completed | Efficacy and Safety of Diclofenac Potassium 25 mg Tablet Taken Three Times Daily in Subjects With Acute Joint NCT01666197 | Novartis | Phase 4 |
| Completed | Evaluation of Therapeutic Effects of LED (627 +/- 10nm) The Initial Phase of the Ankle Sprains Treatment NCT02433964 | Universidade do Vale do Paraíba | N/A |
| Withdrawn | Efficacy of PENNSAID® for Pain Management in the Emergency Department NCT01350622 | University of Utah | N/A |
| Unknown | Cast Immobilization Versus Functional Therapy for Acute, Severe Lateral Ankle Sprains NCT01446341 | University of British Columbia | N/A |
| Completed | Effect of Joint Mobilization in the Treatment of Chronic Ankle Instability NCT01438905 | Creighton University | N/A |
| Completed | Effects of Ankle Support on Muscle Activation and Function NCT01423513 | Creighton University | N/A |
| Completed | Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Applied 4 Times Daily in Subjects With Acute Ankle Spr NCT01255423 | Novartis | Phase 3 |
| Completed | The Effect of Five-Toed Socks on Postural Control Among Active Individuals Who Have Chronic Ankle Instabilitie NCT01210612 | University of Toledo Health Science Campus | N/A |
| Unknown | Effects of Talocrural Joint Mobilizations in the Treatment of Subacute Lateral Ankle Sprains NCT01117909 | University of Virginia | N/A |
| Completed | Ankle Sprain Rehabilitation With the Wii Balance Board NCT01449760 | University Hospital, Geneva | N/A |
| Completed | Compression Stockings in Ankle Sprain NCT01259752 | Assistance Publique - Hôpitaux de Paris | Phase 3 |
| Completed | A Comparison of Early Mobilization Versus Traditional Treatment for Acute Ankle Sprains. NCT01134653 | Nationwide Children's Hospital | N/A |
| Completed | FS-67 in the Treatment of Pediatric Patients With Ankle Sprain NCT01037816 | Hisamitsu Pharmaceutical Co., Inc. | Phase 4 |
| Completed | HKT-500 in the Treatment of Adult Patients With Ankle Sprain NCT00927641 | Hisamitsu Pharmaceutical Co., Inc. | Phase 3 |
| Completed | Diclofenac Patch for Treatment of Acute Pain Due to Mild to Moderate Ankle Sprain NCT00869180 | Cerimon Pharmaceuticals | Phase 3 |
| Completed | Ankle Sprains and Corticospinal Excitability NCT00847769 | University of Southern California | Phase 1 / Phase 2 |
| Completed | Manual Therapy and Exercise Versus Home Exercises in the Management of Patients Status Post Ankle Sprain NCT00797368 | Franklin Pierce University | N/A |
| Completed | HKT-500 in Adult Patients With Ankle Sprain NCT00680784 | Hisamitsu Pharmaceutical Co., Inc. | Phase 3 |
| Terminated | Diclofenac Patch for Treatment of Mild to Moderate Ankle Sprain NCT00640705 | Cerimon Pharmaceuticals | Phase 2 / Phase 3 |
| Completed | Efficacy and Safety of Diclofenac Diethylamine 2.32% Gel in Patients With Acute Ankle Sprain NCT00573768 | Novartis | Phase 2 |
| Completed | Open Label Comparative Study On Celecoxib Efficacy And Safety Vs Non-Selective NSAID In Acute Pain Due To Ankl NCT00446797 | Pfizer's Upjohn has merged with Mylan to form Viatris Inc. | Phase 4 |
| Completed | Effects of Proximal and Distal Tibiofibular Joint Manipulation on Lower Extremity Muscle Activation, Ankle Ran NCT00601471 | University of Virginia | N/A |
| Completed | Effects Of High Voltage Pulsed Current On Post-Traumatic Injuries NCT00732017 | Universidad Industrial de Santander | N/A |
| Completed | Applicability of the Ottawa Ankle Rules NCT01561365 | Hadassah Medical Organization | N/A |