| Recruiting | Effects of Graded Motor Imagery in Individuals With Foot/Ankle Osteoarthritis NCT07417436 | Alanya Alaaddin Keykubat University | N/A |
| Unknown | Total Ankle Replacement Using Guides, Expert Versus Trainee NCT05729958 | Centre for Orthopaedic Research Alkmaar | — |
| Active Not Recruiting | Development of Stance Control Orthotic Knee Joint For Improvement of KAFO Users NCT06404801 | Superior University | — |
| Recruiting | Early MOtion Total Ankle Artroplasty NCT06525545 | Istituto Ortopedico Rizzoli | N/A |
| Recruiting | Comparison of Customized and Standard Total Ankle Prostheses NCT06193057 | Istituto Ortopedico Rizzoli | N/A |
| Unknown | Development of Biomedical Technology for the Treatment of Ankle Cartilage Using Injectable Biocomposite Hydrog NCT06028763 | National Scientific Center of Traumatology and Orthopedics named after academician N.D. Batpenov | N/A |
| Withdrawn | Lateral Approach Versus Anterior Approach in Total Ankle Replacement NCT05562154 | John Femino | N/A |
| Completed | Injections of SVF in Ankle Osteoarthritis NCT04998162 | Istituto Ortopedico Rizzoli | N/A |
| Terminated | Evaluation of the Single Injection of BMAC vs HA in the Treatment of the Ankle Osteoarthritis NCT04883892 | Istituto Ortopedico Rizzoli | N/A |
| Terminated | Evaluating Intra-articular Injection of Axolotl Ambient Compared to Saline in Subjects With Ankle Osteoarthrit NCT05092646 | Axolotl Biologix | Phase 1 / Phase 2 |
| Terminated | A Disease-based Treatment Study for Diagnosed Osteoarthritis Utilizing Adipose-derived Regenerative Cells NCT04405297 | Sanford Health | — |
| Terminated | TAR 2 Weeks vs 6 Weeks Post-Operative Weight-Bearing NCT04709861 | University of Oklahoma | — |
| Completed | Assessment of Preoperative and Postoperative Ankle Kinematics NCT05868759 | Istituto Ortopedico Rizzoli | N/A |
| Active Not Recruiting | Post- Approval Hintermann Series H® Study 1 NCT06514196 | DT MedTech, LLC | — |
| Completed | Indications for Osteochondral Allograft Transplantation NCT03711747 | University of Missouri-Columbia | — |
| Completed | Do Rocker Bottom Shoes and Ankle-Foot Orthoses Reduce Pain and Improve Mobility for Ankle Osteoarthritis Patie NCT03524729 | VA Office of Research and Development | N/A |
| Unknown | New App for Monitoring Postoperative Pain in Total Ankle Replacement NCT03777072 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Unknown | Phi Angle and Antero-medial Pain in Total Ankle Replacement Follow-up NCT03772236 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Completed | Cryoneurolysis for Improvements in Pain, ADL and QOL in Patients With Ankle Osteoarthritis NCT03567187 | University of Kansas Medical Center | N/A |
| Unknown | Tranexamic Acid in Major Orthopedic Surgery: Comparison of 3 Dosage Regimen NCT03573245 | CUF Santarém Hospital | — |
| Completed | A Single Intraarticular Injection of Platelet-Rich Plasma on Pain and Physical Function in Patients With Ankle NCT04022928 | Kaohsiung Veterans General Hospital. | N/A |
| Completed | Gait Analysis Following Total Ankle Replacement and Subtalar Fusion NCT03356951 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Completed | Efficacity of a Rigid Ankle Foot Orthosis for Persons With Ankle Osteoarthritis NCT04312373 | Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est | — |
| Unknown | Ankle Osteoarthritis NCT03157141 | Hospices Civils de Lyon | — |
| Terminated | Improving the Detection, Classification and Treatment of Misaligned Arthritic Ankles NCT03440008 | VA Office of Research and Development | — |
| Completed | Orthotic Dose Response Study NCT02629731 | VA Office of Research and Development | N/A |
| Completed | Gait Asymmetry Assessed Using Portable Gait Analysis System NCT02489188 | University Hospital, Basel, Switzerland | — |
| Completed | Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement NCT01504438 | Duke University | N/A |
| Completed | Effects of Intraarticular Botulinum Toxin A in Ankle Osteoarthritis NCT01760577 | Kaohsiung Veterans General Hospital. | N/A |
| Completed | Cross-cultural Adaptation and Validation of the Ankle Osteoarthritis Scale (AOS) for Use in French-speaking Po NCT02508233 | Université de Sherbrooke | — |
| Completed | Total Ankle Replacement for Ankle Arthritis NCT01986244 | Duke University | — |