| Not Yet Recruiting | Performance and Safety Follow-up of Bioabsorbable Headless Inion CompressOnTM Screws in the Fixation of Bone F NCT07473947 | Inion Oy | N/A |
| Recruiting | Efficacy and Clinical Feasibility of the Ankle Muscle Power (AMP) Program for Return to Duty After an Ankle Fr NCT07173088 | Brian W. Noehren | N/A |
| Withdrawn | Waterproof Casting Versus Standard Casting for Short Leg Walking Casts NCT04961957 | West Virginia University | N/A |
| Recruiting | Neuromuscular Electrical Stimulation in Foot and Ankle Surgery NCT06370325 | NYU Langone Health | N/A |
| Not Yet Recruiting | Post-surgical Outcomes With Anabolic Agent Use in High-risk Ankle Fractures: A Pilot RCT NCT06303284 | University of Calgary | Phase 1 / Phase 2 |
| Completed | Outcome And Complications Assessment In The Surgical Treatment Of Distal Fibular Fractures NCT06599554 | Istituto Ortopedico Rizzoli | — |
| Withdrawn | Custom Dynamic Orthoses to Reduce Articular Contact Stress NCT05209347 | University of Iowa | N/A |
| Completed | Effects of Postoperative Kinesio Taping in Weber Type B Lateral Malleolar Fractures NCT06958133 | Fatih Sultan Mehmet Training and Research Hospital | N/A |
| Recruiting | The Benefit of Repairing the Deltoid Ligament in Unstable Ankle Fractures NCT06568276 | Ostfold Hospital Trust | N/A |
| Not Yet Recruiting | Impact of Suture Technique on Wound Healing in Ankle Fracture Surgery: A Randomized Controlled Trial NCT06496698 | University of Puerto Rico | N/A |
| Unknown | Sciatic Nerve Block for Ankle and Leg Fracture Manipulation in the Emergency Department NCT06329752 | Fondazione IRCCS Policlinico San Matteo di Pavia | N/A |
| Not Yet Recruiting | Prospective Follow-up of the Results of Nail Arthrodesis of the Ankle NCT06338566 | Direction Centrale du Service de Santé des Armées | — |
| Recruiting | Single-Window Versus Two-Window Posterolateral Approach for Malleolar Fractures NCT07481266 | muhammed kılıç | N/A |
| Completed | Tactile Incentiviser Improves Partial Weight Bearing After Lower-Limb Surgery NCT06989554 | Università degli Studi dell'Insubria | N/A |
| Not Yet Recruiting | Functional Outcomes Following Ankle Fracture Fixation With or Without Ankle Arthroscopy NCT06086223 | Assiut University | N/A |
| Unknown | Diagnostic Ultrasonography in Physiotherapy NCT05916300 | Petr Routner | — |
| Unknown | Effect of Cool Spray and Cold Packs in Reducing Preoperative Edema and Pain in Ankle Fractures in Ubonratchath NCT06293209 | Thai Traditional Medical Knowledge Fund | N/A |
| Recruiting | Fibulink Syndesmosis Repair System With Early Full-Weight Bearing NCT06085586 | Maimonides Medical Center | N/A |
| Unknown | Hardware Removal After ORIF of Ankle Fractures NCT05798741 | Hôpital Fribourgeois | N/A |
| Unknown | Improving Patient Understanding in Preoperative Informed Consent Process of Trauma Patients Using a Mixed Real NCT06062797 | LMU Klinikum | N/A |
| Recruiting | Weber B Ankle Fractures With Associated Posterior Malleolus Fracture NCT05413707 | Haukeland University Hospital | N/A |
| Recruiting | Performance and Safety Evaluation of Inion CompressOn Screw in Foot and Ankle Surgeries. PMCF Investigation NCT05555459 | Inion Oy | N/A |
| Recruiting | Simplified Post Op Rehabilitation for Ankle and Pilon Fractures NCT05280639 | University of Virginia | N/A |
| Unknown | A Comparative Study Between Positional and Lag Screws for the Fixation of Medial Malleolar Fractures NCT05573516 | Kasr El Aini Hospital | N/A |
| Completed | WALANT and Spinal Anesthesia Comparison of Clinical Result in Ankle Fractures NCT06077344 | Istanbul University | N/A |
| Unknown | Exparel Use in Peripheral Nerve Blocks and Local Infiltration for Foot and Ankle Surgery: A Randomized Control NCT05494645 | St. Luke's Hospital, Pennsylvania | Phase 4 |
| Completed | Outpatient Versus Inpatient Surgery for Ankle Fractures NCT05389436 | Christian Grundtvig Refstrup Rasmussen | N/A |
| Unknown | Nerve Block for Pain Control After Fracture Surgery NCT05391464 | MaineGeneral Health | N/A |
| Active Not Recruiting | Functional Orthosis Versus Cast Immobilization for Partially Unstable Weber B Ankle Fractures NCT05412693 | Ostfold Hospital Trust | N/A |
| Recruiting | FRAME Study (Frailty-Related Ankle Fracture Management and Evaluation) NCT05131321 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | — |
| Active Not Recruiting | Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Pati NCT05185115 | Nantes University Hospital | Phase 3 |
| Terminated | Diabetic Fibular Nail Study NCT05204485 | University of Chicago | N/A |
| Withdrawn | Fibular Nail vs Plate in Ankle Fractures NCT04303663 | Chinese University of Hong Kong | N/A |
| Recruiting | Comparing Clinical Outcomes of Suture Button Versus Fibulink Fixation for Acute Ankle Syndesmosis Injuries NCT05729542 | University of California, San Diego | N/A |
| Withdrawn | CBD for Pain Reduction and Opioid Use After Ankle and Tibia Fracture ORIF NCT04768478 | NYU Langone Health | Phase 4 |
| Recruiting | Correlation Between Intraoperative Tourniquet Use and Limb pH, Functional Measures and Patient-reported Outcom NCT05445960 | Oregon Health and Science University | N/A |
| Unknown | A New Method for Deltoid Ruptures: Gap Sign NCT05188391 | Goztepe Training and Research Hospital | N/A |
| Completed | Postoperative Computed Tomography Detection of Syndesmotic Malreduction in Ankle Fractures NCT07338149 | Cairo University | — |
| Active Not Recruiting | Local Multimodal Injection Versus Regional Anesthesia in Controlling Pain for Treating Rotational Ankle Fractu NCT05019638 | University of Utah | EARLY_Phase 1 |
| Unknown | A Cohort Study of Bioabsorbable Screws for Syndesmosis Fixation Fixation in Ankle Fracture NCT05662449 | NHS Grampian | — |
| Unknown | Vertical Distance Between Medial and Lateral Malleolus in Normal Population NCT04826289 | Assiut University | — |
| Active Not Recruiting | Go Fit Fast, Recovery Trajectory Using PROMIS®, Linking PROMIS® NCT04113044 | AO Innovation Translation Center | — |
| Completed | Post Operative Ankle Splint Study - Prospective Multi Center Randomized Controlled Trial NCT04796168 | Kuwait Institute for Medical Specialization | N/A |
| Completed | Cryotherapy Reduces Time to Surgery and Local Complication in Patients With Ankle Fractures NCT06396364 | Azienda Ospedaliera San Camillo Forlanini | N/A |
| Withdrawn | Unna Boots for Ankle Fracture Swelling NCT04086927 | Medical University of South Carolina | N/A |
| Active Not Recruiting | RCT Comparing Non-operative vs Operative Treatment of Suprasyndesmotic Ankle Fractures. NCT04615650 | Sykehuset Innlandet HF | N/A |
| Completed | The Therapeutic Effect of Dau-Di-Wu-Gong in Patient With Ankle Fracture NCT03805347 | Changhua Christian Hospital | Phase 1 / Phase 2 |
| Completed | Opiate Free Multimodal Pain Pathway in Elective Foot and Ankle Surgery: A Prospective Study NCT04771741 | Prisma Health-Midlands | — |
| Completed | Telerehabilitation Following Ankle Fractures NCT04235907 | Johns Hopkins University | N/A |
| Unknown | Deep Deltoid Ligament Integrity in Weber B Ankle Fractures - Mini-invasive Arthroscopic Evaluation. NCT04674046 | Ostfold Hospital Trust | N/A |
| Recruiting | Randomized Controlled Trial for Ankle Fracture Pain Control NCT03696199 | Lahey Clinic | Phase 4 |
| Recruiting | Immediate Vs. Delayed Weight Bearing Postoperative Protocol in Diabetic Ankle Fractures NCT03966027 | Kyle Schweser MD | N/A |
| Unknown | High Ankle Block in Ankle Fractures NCT04292691 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Factors Influencing the Risk of Surgical Site Infections and Wound Complications in Operatively Treated Ankle NCT04379791 | University Hospital, Basel, Switzerland | — |
| Unknown | Orthopaedic Conservative Treatment in the Time of Covid-19 Pandemic NCT04623346 | Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization | — |
| Completed | Iterative Design of Custom Dynamic Orthoses to Reduce Articular Contact Stress NCT04562896 | University of Iowa | N/A |
| Unknown | Use of Sterile HemaClear Tourniquet Below Calf Versus Pneumatic Tourniquet at the Thigh for Ankle and Foot Sur NCT04818775 | Hospital do Coracao | N/A |
| Completed | Deltoid Ligament Arthroscopic Repair in Ankle Fractures: Case Series NCT04473638 | Federal University of São Paulo | — |
| Completed | Postoperative Aspirin and Ankle Fracture Healing NCT03765619 | University of Alabama at Birmingham | EARLY_Phase 1 |
| Completed | Weight-bearing Radiographs to Evaluate Stability in Ankles With Isolated Weber Type B Fractures. NCT03831009 | Ostfold Hospital Trust | N/A |
| Completed | Prognostic Factors Following Ankle Fractures NCT03741556 | Sygehus Lillebaelt | — |
| Unknown | Swedish Multicenter Trial of Outpatient Prevention of Leg Clots NCT03259204 | Karolinska University Hospital | N/A |
| Unknown | Operative Versus Non Operative Management Outcomes of Isolated Lateral Malleolar Weber B Ankle Fractures NCT03625154 | Cedars-Sinai Medical Center | N/A |
| Terminated | How to Reduce Dry Needling Pain in Treatment of Trigger Points of Muscle Triceps Sural in Ankle Post Fracture NCT05193695 | Becerra, Pablo | N/A |
| Unknown | Outcome of Low Energy Ankle Fractures NCT03212768 | Assiut University | — |
| Unknown | Prevention of Posttraumatic Osteoarthritis After Acute Intraarticular Fractures NCT03769909 | University of Southern Denmark | — |
| Withdrawn | Arthroscopic Assisted Open Reduction Internal Fixation Versus Open Reduction Internal Fixation in Ankle Fractu NCT03084263 | Corewell Health West | N/A |
| Completed | Immediate Weight-Bearing Ankle Study NCT03032653 | Fraser Orthopaedic Research Society | N/A |
| Completed | Perfusion Index and Pain in Ankle Surgery NCT03158753 | Rune Sort | — |
| Recruiting | An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA NCT03809520 | J L Marsh | N/A |
| Unknown | Treatment Strategy of Ankle Fracture Combined With Deltoid Ligament Rupture NCT02977910 | Liming Cheng | N/A |
| Completed | Efficacy of Multimodal Periarticular Injections in Operatively Treated Ankle Fractures NCT02967172 | University of Iowa | Phase 4 |
| Completed | Ropivacaine Versus Bupivacaine as Preemptive Analgesia in Surgical Site in Ankle Fracture Patients NCT02949674 | Instituto Mexicano del Seguro Social | Phase 3 |
| Completed | Effect of Toradol on Post-operative Foot and Ankle Healing NCT03727048 | Rothman Institute Orthopaedics | Phase 4 |
| Unknown | Intramedullary Nailing Versus Plate Fixation of Ankle Fractures. A Prospective, Randomized Controlled Trial. NCT03377205 | Oslo University Hospital | N/A |
| Unknown | Study of Re-operation Rate After Introduction of Evidence Based Algorithm for the Treatment of Ankle Fractures NCT03107767 | Hvidovre University Hospital | N/A |
| Enrolling By Invitation | Conjoint Analysis of Patient Preferences in Joint Interventions NCT02664337 | Duke University | N/A |
| Completed | Outcome Following Semitubular Plate vs. Polyaxial Locking Plates NCT04370561 | Technical University of Munich | N/A |
| Completed | Ziptight or Tricortical Screw Fixation of Acute Tibiofibular Syndesmotic Injury NCT02930486 | Vestre Viken Hospital Trust | N/A |
| Completed | The Results of Middle-sized Posterior Malleolus Fractures: Fixed Versus Non-fixed NCT05084794 | Istanbul University - Cerrahpasa | N/A |
| Unknown | Comparison of the Results of Complex Ankle Fractures Treated With and Without Ankle Arthroscopy NCT02449096 | Ludwig-Maximilians - University of Munich | N/A |
| Completed | Preliminary Review of Cold and Active Compression Therapy for Traumatic Calcaneus or Ankle Fractures NCT02498717 | AdventHealth | N/A |
| Completed | Open Reduction Syndesmosis Tightrope Versus Screw Fixation NCT02199249 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | N/A |
| Completed | Prediction and Secondary Prevention of Fractures NCT02608801 | Oslo University Hospital | — |
| Unknown | Preoperative Treatment of Malleolar Fractures NCT02444468 | Hospital of Southern Jutland | N/A |
| Unknown | Outcome of Rehabilitation Following Internally Fixed Ankle Fractures NCT02160197 | Countess of Chester NHS Foundation Trust | N/A |
| Unknown | Compression in Anklefracture Treatment, The CAT-study NCT02481076 | Hillerod Hospital, Denmark | N/A |
| Unknown | AORIF Complex Ankle Fractures NCT04033848 | Ludwig-Maximilians - University of Munich | — |
| Completed | A Comparison Of Block Quality In Anterior And Posterior Approach To Sciatic Nerve Block NCT03607292 | Bagcilar Training and Research Hospital | N/A |
| Completed | Robot-assisted Rehabilitation of Ankle Fractures: Efficacy and Comparison With Traditional Methods NCT02923479 | Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoro | N/A |
| Completed | Ankle Fracture vs Ankle Fracture-Dislocation NCT02198768 | Wake Forest University Health Sciences | — |
| Completed | Accumulative Effects of Talus Mobilization NCT02244008 | Federal University of Minas Gerais | N/A |
| Terminated | Post Operative Quality of Life and Pain in Ankle Fractures: Cast Versus Functional Treatment NCT02823275 | Rijnstate Hospital | N/A |
| Completed | Combined Randomised and Observational Study of Type B Ankle Fracture Treatment NCT01134094 | The University of New South Wales | N/A |
| Unknown | Combined Randomised and Observational Study of Surgery for Type B Ankle Fracture Treatment NCT03083028 | The University of New South Wales | N/A |
| Completed | Evaluation of Cork Splint Materials Instead of Plaster Splint for Children NCT00285961 | University Hospital, Ghent | N/A |