| Recruiting | VibraCool Device to Reduce Pain and Opioid Use After Anterior Cruciate Ligament Reconstruction (ACLR) NCT06456268 | Columbia University | N/A |
| Recruiting | Michigan Split-belt Treadmill Training Program to Improve Long-Term Knee Biomechanics After ACL Reconstruction NCT06529692 | University of Michigan | N/A |
| Recruiting | Outcomes and Complication Rates of Anterior Cruciate Ligament Reconstruction Using the "Over-the-top" Techniqu NCT07041242 | Stefano Zaffagnini | — |
| Recruiting | Long-term Clinical and Radiographic Results of Revision Anterior Cruciate Ligament Reconstruction Using a Sing NCT06868147 | Istituto Ortopedico Rizzoli | — |
| Recruiting | Conservative Treatment With Blood Flow Restriction in Patients With Total ACL Rupture. "Randomized Clinical Tr NCT06727344 | European University Cyprus | N/A |
| Not Yet Recruiting | Primary ACL Reconstruction in Patient Over 40 Years: Allograft Versus Autograft NCT06584838 | Università Vita-Salute San Raffaele | — |
| Recruiting | Michigan Split-belt Treadmill Training Program to Improve Acute Knee Biomechanics After ACL Reconstruction NCT06529679 | University of Michigan | N/A |
| Recruiting | Anterior Cruciate Ligament Study NCT06194682 | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | — |
| Withdrawn | Blood Flow Restriction Following ACLR NCT04086030 | Rush University Medical Center | N/A |
| Recruiting | Exploring Prolonged AMR in ACL Reconstructed Patients NCT06430775 | University Ghent | — |
| Active Not Recruiting | Comparison of Semitendinosus and Quadriceps Grafts for Anterior Cruciate Ligament Reconstruction NCT06167343 | Universidad de Granada | N/A |
| Enrolling By Invitation | Exparel vs Block for ACL Reconstruction NCT06006624 | Rothman Institute Orthopaedics | Phase 4 |
| Completed | Genicular Nerve Blocks for Anterior Cruciate Ligament Knee Surgery NCT05720949 | Hospital for Special Surgery, New York | Phase 4 |
| Recruiting | Mindfulness and ACL Surgery NCT05542563 | University of Wisconsin, Madison | N/A |
| Terminated | Playmaker 3D Printed Knee Extender NCT05878652 | Sanford Health | N/A |
| Completed | Evaluation Of Clinical Results And Imaging Of Anterior Cruciate Ligament Reconstruction With Orthopure Xt NCT06091488 | Istituto Ortopedico Rizzoli | N/A |
| Completed | Reduced Knee Flexion Strength 18 Years After ACL Reconstruction in Hamstring Group Compared to Patellar Tendon NCT05876013 | St. Olavs Hospital | — |
| Unknown | Post Operative Pain Management Through Adductor Canal Block With Bupivacaine for ACL Reconstruction NCT05161221 | Rothman Institute Orthopaedics | Phase 3 |
| Unknown | What is the Effect of Vision on Movement Control in Anterior Cruciate Ligament Reconstructed Patients 7 Months NCT05121857 | Sports Surgery Clinic, Santry, Dublin | — |
| Unknown | What is the Influence of Visual-motor Reliance on Planned and Unplanned Change of Direction Biomechanics 7 Mon NCT05141812 | Sports Surgery Clinic, Santry, Dublin | — |
| Recruiting | LIVing Donor Allograft for Anterior Cruciate Ligament Reconstruction Study NCT05395767 | Maidstone & Tunbridge Wells NHS Trust | N/A |
| Unknown | Comparing Adductor Canal Block and Adductor Canal Block-Local Infiltration Analgesia for Post-operative Pain M NCT04721119 | Ottawa Hospital Research Institute | N/A |
| Unknown | Prospective Analysis of Introperative RegenLab PRP and Hyaluronic Acid in Patients With Knee ACL Tear NCT04586361 | Kaohsiung Veterans General Hospital. | Phase 4 |
| Completed | The Effect of Bone-void Filler on Anterior Knee Pain Following ACL Reconstruction NCT04533880 | NYU Langone Health | N/A |
| Unknown | Risk of Osteoarthritis of the Knee at Least 5 Years After ACL Reconstruction: Comparative Study Between an Iso NCT05123456 | Ramsay Générale de Santé | N/A |
| Unknown | Laval University Rouge et or Post ACL Surgery Program Effectiveness NCT04137003 | Laval University | N/A |
| Completed | THE EFFECT OF RAMP LESION REPAIR ON RETURN TO SPORTS IN ANTERIOR CRUCIATE LIGAMENT RECONSTRUCTION NCT05048420 | Medipol University | N/A |
| Completed | Acupuncture ACL (Anterior Cruciate Ligament) NCT03711734 | Hospital for Special Surgery, New York | N/A |
| Withdrawn | Dynamic ACL Brace: In Vivo Kinematics NCT03670550 | Steadman Philippon Research Institute | N/A |
| Unknown | Semitendinosus Graft as Meniscal Transplant NCT04753424 | Karolinska Institutet | — |
| Active Not Recruiting | Use of an Osteoconductive Scaffold in ACL-Reconstruction NCT03462823 | Sandro Fucentese | N/A |
| Unknown | Mechanical Perturbation Training for ACL Injury Prevention NCT03080402 | University of Delaware | N/A |
| Completed | ACL-reconstruction vs ACL-reconstruction With EAT NCT02913404 | University of Pittsburgh | N/A |
| Completed | Tibial Tunnel Widening in Anterior Cruciate Ligament (ACL) Reconstruction-Comparing Two Bioscrews NCT01727739 | Panam Clinic | N/A |
| Withdrawn | Decreasing Knee Injury Risk Factors With Neuromuscular Training NCT01433718 | Ohio University | N/A |